Background
Type: Article

An efficient, expeditious, and diastereoselective one-pot pseudo-five-component reaction for the synthesis of new bis-Betti bases under catalyst-free conditions

Journal: Tetrahedron Letters (00404039)Year: 13 June 2012Volume: 53Issue: Pages: 3086 - 3090
DOI:10.1016/j.tetlet.2012.04.037Language: English

Abstract

A novel, diastereoselective, one-pot synthesis of new bis-Betti bases via condensation of dihydroxynaphthalene, two equivalents of aryl aldehydes, and two equivalents of 3-amino-5-methylisoxazole is reported. Conversion into the adducts was almost quantitative without the use of solvent or catalyst. The reaction conditions are very simple and enable easy isolation of the product. © 2012 Elsevier Ltd. All rights reserved.