Highly efficient aminolysis of epoxides catalyzed by reusable zirconyl triflate, ZrO(OTf)2

Abstract

Efficient ring opening of epoxides with aromatic amines catalyzed by ZrO(OTf)2 is reported, and the corresponding β amino (beta-amino acid) alcohols were obtained in high yields in CH3CN as solvent. The reactions were carried out at room temperature and in the presence of only 1.25 mol% of ZrO(OTf)2. This catalyst can be reused several times without loss of its activity. Copyright © Taylor & Francis Group, LLC.