Synthesis of 2,6′-dioxo-1′,5′,6′,7′- tetrahydrospiro[indoline-3,4′-pyrazolo[3,4-b]pyridine]-5′- carbonitriles via a one-pot, three-component reaction in water

Abstract

A one-pot, three-component condensation reaction of an isatin, aminopyrazole, and alkyl cyanoacetate in water to give 2,6′-dioxo- 1′,5′,6′,7′-tetrahydrospiro[indoline-3, 4′-pyrazolo[3,4-b]pyridine]-5′-carbonitrile with good yields, at 90 C, using a Et3N as catalyst, is described. © 2012 American Chemical Society.