Jamshidi, S.,
Ansorge L.,
David Vaca-Jiménez S.,
Gerbens-Leenes W.,
Aldaya M.M.,
Arastou, K.,
Wöhler L. Ecological Indicators (1470160X)
Faraji M.,
Yalameha, S.,
Hosseine M.,
Bafekry A.,
Bagheri, A.,
Abbasi, S.,
Mahmoodi, M.,
Akhavan, A.,
Blattner, F.R. Advanced Theory and Simulations (25130390)(10)pp. 101-107
In this study, first-principles calculations are used to systematically study the structural, mechanical, and optical properties of the honeycomb AuTe monolayer, as well as the influence of layered structures on their stability and electronic properties. Additionally, the effect of alkali metal atoms decorating AuTe-X (X = Li, Na, K) and related structural, electronic, optical, and topological insulator properties, along with the biaxial strain on the lithium-decorated AuTe-Li monolayer are investigated. The AuTe monolayer shows metallic characteristics, and when alkali metal atoms are decorated onto it, the resulting structures remain dynamically stable. Notably, the introduction of Li, Na, and K atoms induces bandgap opening in the decorated Li and Na monolayers near the Fermi level, causing metal-to-narrow bandgap semiconductor and Dirac semi-metal transitions. Conversely, the metallic nature of the decorated AuTe-K monolayer is retained. The emergence of a bandgap near the Fermi level, caused by alkali metal decoration, triggers a topological phase transition in AuTe-Li, AuTe-Na, and AuTe-K monolayers. Optical analyses reveal that AuTe-K decorated structure enhances light absorption in the visible spectrum. Consequently, the findings provide insights into the decoration of these two-dimensional material monolayers, potentially advancing research and motivating the production of such monolayers for current nanodevice applications. © 2024 Wiley-VCH GmbH.
Zarei R., Khaledi Darvishan A., Porto P., Zare, M.R.
Ecological Indicators (1470160X)
Topographic variables play important roles not only on soil erosion, but also on sediment redistribution inside the watersheds, both of which can be studied using radiotracer of 137Cs. In this regard, the current research aims to establish a sediment budget using ecological indicators of topographic metrics and radiotracers and to examine the relationship between topographic metrics and the sediment budget components in two scales of pixel and hillslope. To achieve the study purposes, soil erosion and redistribution map was prepared based on 137Cs method and work units’ approach in the 102.14 ha control sub-watershed of Khamsan representative watershed, western Iran. Then, the 1-m digital elevation model was used to extract the topographic metrics. The sediment budget components including total erosion, total deposition, net erosion and sediment delivery ratio and topographic metrics including slope angle, slope length, profile curvature, plan curvature, stream power index, topographic wetness index and flow accumulation were calculated for 14 selected hillslopes. The results showed that land use dominates the rate of erosion and sedimentation of the watershed in the long term (60–70 years). Out of 526.87 t y−1 of erosion occurred in the study sub-watershed, only 20.26 t y−1 were redistributed within the watershed, and 506.61 t y−1 were delivered to the watershed outlet and the specific net erosion was calculated at the rate of 5.05 (t/ha y−1). The amount of erosion and sedimentation was noticeably affected by the reduction of the slope angle and changing rangelands to agriculture in the lower part of the slopes. At the pixel scale, the LS, slope angle and stream power index had significant positive correlations of 0.57, 0.60 (sig. < 0.01) and 0.39 (sig. < 0.05) with the rate of erosion and sedimentation, respectively. In the hillslope scale, with the decrease of the slope angle down the slopes, the intensity of erosion increased due to the land use change from rangeland to rainfed agriculture in the downslopes. Therefore, land use change to agriculture on lower slopes exacerbates soil erosion, emphasizing the need for targeted land management practices. © 2024 The Author(s)
Leung D., Tsai O., Hashemi K., Tayebi B., Tayebi M.A.
International Conference on Information and Knowledge Management, Proceedings (21550751)pp. 4653-4660
SQL injection (SQLi) compromises database-driven applications by enabling attackers to insert malicious SQL commands via input fields, potentially leading to unauthorized access, data manipulation, or system compromise. In recent years, alongside the development of various rule-based Web Application Firewalls (WAFs) aimed at mitigating SQL injection attacks, there has also been a notable rise in the utilization of machine learning and deep learning techniques to address this issue. Although significant progress has been made in these studies, detecting and mitigating SQLi-related attacks continues to present a significant challenge. A crucial factor contributing to the lack of extensive SQLi detection solutions is the absence of a comprehensive testing methodology. In this work, we introduce XploitSQL-an innovative approach to advance adversarial SQL injection generation by leveraging language models and reinforcement learning. Our model is trained to produce evasive SQLi samples, enhancing the robustness of SQLi detection models and offering opportunities for more comprehensive detection strategies. To assess the efficacy of the proposed method, we employed state-of-the-art SQL injection detection models in conjunction with commercially available web-based firewalls. Across all tested detection models, detection rates declined when faced with evasive samples generated by XploitSQL. Furthermore, our model outperforms existing methods for generating attack samples. © 2024 ACM.
Valian H., Hassan Emami M., Heidari A., Amjadi E., Fahim A., Lalezarian A., Ali Ehsan Dehkordi S., Maghool F.
Preventive Medicine Reports (22113355)
Adenoma detection rate (ADR) is an imperative quality measure for colorectal cancer (CRC) screening. This retrospective observational study aimed to determine the trend of polyp detection rate (PDR) and ADR in asymptomatic average- and high-risk participants in different age groups who underwent screening colonoscopy over the seven years from April 2012 to March 2019 in a tertiary gastroenterology referral center of Iran. Of 1676 participants, 51.8 % were men (mean age 52.3 years). The overall PDR and ADR were 22.7 %, and 13.5 %, respectively. Both Polyps and adenomas were more common in age groups 51–59 and ≥60 years in high-risk patients than in the corresponding groups of average-risk patients (p < 0.05). Also, both PDR and ADR were more frequent in men than in women among all studied age groups, but it was statistically significant only for the youngest age group (16.8 % versus 10.5 %, p < 0.05) for PDR and the oldest age group (19.7 % versus 13 %, p < 0.05) for ADR, respectively. The trend of total ADR was upward over 7 years in both average-risk (6.7 % to 13.3 %) and high-risk (9.8 % to 27 %) groups and across all age groups in both sexes. Multivariable logistic regression revealed that high-risk individuals had an elevated risk of adenoma compared with average-risk patients (OR: 1.6, p = 0.006). Substantial variation in thresholds of polyp and adenoma detection by age, sex, and risk categories emphasizes the need for a risk-adapted approach to CRC screening and prevention programs. © 2023
Sajadi M., Fazilati M., Nazem H., Mahdevar M., Ghaedi, K.
Cancer Cell International (14752867)(1)
In this original article [1], the affiliation for the authors Manizheh Sajadi, and Habibollah Nazem was incorrect. The correct affiliation is as follows “Department of Biochemistry, Faculty of Science, Payame Noor University, Tehran, Iran”. Also, the correct academic email address of the author Dr. Fazilati should be mfazilati@pnu.ac.ir. © 2023, The Author(s).
Rahimi A., Malakoutikhah Z., Rahimmanesh I., Ferns G.A., Nedaeinia R., Ishaghi S.M.M., Dana, N., Javanmard, S.H.
Cancer Cell International (14752867)(1)
The metastasis of melanoma cells to regional lymph nodes and distant sites is an important contributor to cancer-related morbidity and mortality among patients with melanoma. This intricate process entails dynamic interactions involving tumor cells, cellular constituents, and non-cellular elements within the microenvironment. Moreover, both microenvironmental and systemic factors regulate the metastatic progression. Central to immunosurveillance for tumor cells are natural killer (NK) cells, prominent effectors of the innate immune system with potent antitumor and antimetastatic capabilities. Recognizing their pivotal role, contemporary immunotherapeutic strategies are actively integrating NK cells to combat metastatic tumors. Thus, a meticulous exploration of the interplay between metastatic melanoma and NK cells along the metastatic cascade is important. Given the critical involvement of NK cells within the melanoma tumor microenvironment, this comprehensive review illuminates the intricate relationship between components of the melanoma tumor microenvironment and NK cells, delineating their multifaceted roles. By shedding light on these critical aspects, this review advocates for a deeper understanding of NK cell dynamics within the melanoma context, driving forward transformative strategies to combat this cancer. © 2023, The Author(s).
Bagheri A.R., Aramesh, N., Hasnain M.S., Nayak A.K., Varma, R.S.
Chemical Physics Impact (26670224)
The production of assorted metal nanoparticles based on greener synthesis approaches has garnered immense attention, which influences most humans and the environment. Metal nanoparticles are becoming increasingly useful in many areas of our everyday lives including the medical sciences. In this context, the deployment of advantageous greener methodology opens up new avenues for researchers to generate metal nanoparticles adhering to the green chemistry principles and exploiting the locally available and abundant resources rather than toxic chemicals. Various plant materials can be utilized to synthesize metal nanoparticles as they are easy to access, inexpensive, safe, good for the environment, and can be readily deployed for the biosynthesis of metal nanoparticles of diverse sizes and shapes, as they incorporate unique properties of plant constituents in their assembly. This review article provides a comprehensive discussion on the different approaches to metal nanoparticles using renewable and sustainable plant materials as eco-friendly entities. Finally, the future outlook for the fabrication of metal nanoparticles by means of plant materials as a sustainable method has been discussed. © 2023 The Author(s)
Ghavamnia, M., Tavakoli, M., Rezazadeh, M.
Revista Electronica de Linguistica Aplicada (18859089)pp. 105-123
The present study aimed to examine the issue of production of requests by Iranian EFL learners, native speakers of Persian, and native speakers of English; exploring the type, frequency, and the content of semantic formulae with regards to the status of the interlocutors (higher or of equal power). For the purpose of this study, 30 Persian speaking learners of English were asked to fill out a Discourse Completion Test (DCT), consisting of 12 situations regarding the speech act of request. In addition, 30 native speakers of Persian were also asked to fill out the same DCT, rendered into Persian, for the purpose of investigating L1 transfer. For a cross-linguistic comparison the DCTs were sent to 30 Canadian native speakers of English through e-mail for completion and were then sent back to the researchers after completion. All 90 participants were female ranging between the ages of 20 to 23. The EFL learners were seniors majoring in English. However, the native speakers of Persian were from different majors excluding English. All data were coded and analyzed based on Hudson et al.'s (1995) model. The results revealed that there were differences in the frequency and type of strategies used in requests made by the three groups. For instance, while all three groups used opener (RSM strategy) such as hello, hi, excuse me, and sorry, the native speakers of English used it the most. On the other hand, some strategies were only used by the native speakers of English such as introducing themselves categorized under RSM strategies. In line with Eslamirasekh's (1993) findings, the results revealed the Persian speakers to make requests with less use of supporting strategies (direct strategies) whereas the English speakers produced more supportive strategies (indirect strategies). Overall, the results of this study indicate that making requests is a complex, multi-causal task as it requires the acquisition of the socio-cultural values of the L2 culture.
Reza jalilvand, M., Samiei N.
Internet Research (10662243)(5)pp. 591-612
Purpose: In an environment in which there has been a reduction in consumer trust of both organizations and advertising, as well as a decrease in television advertising, word of mouth (WOM) offers a way to obtain a significant competitive advantage. WOM is especially important in the hospitality and tourism industry, whose intangible products are difficult to evaluate prior to their consumption. When WOM becomes digital, the large-scale, anonymous, ephemeral nature of the Internet induces new ways of capturing, analyzing, interpreting, and managing the influence that one consumer may have on another. The purpose of this paper is to investigate the impact of electronic WOM (eWOM) on a tourism destination choice, using the theory of planned behaviour (TPB). Further, an effort was employed to determine the effect of past travel experience on using eWOM and TPB constructs. Design/methodology/approach: A structural equation modeling procedure was applied to the examination of the influences of eWOM on attitudes towards visiting Isfahan, subjective norms, perceived behavioral control, and travel intention. Analysis of variance (ANOVA) was utilised in order to analysing the relations between these constructs and past travel experience. The research model was tested empirically using a sample of 296 inbound tourists who had experience within the online communities and travelled to Isfahan during the period of research. Findings: Findings indicate that online WOM communications have a significant impact on attitudes toward visiting Isfahan, subjective norms, perceived behavioral control, and intention to travel. In addition, travel experience has a significant impact on using eWOM and TPB constructs. Practical implications: The paper suggests that eWOM activity is more complex than previous research has argued. Managers should consider various eWOM facets and try to motivate tourists for participating in online travel communities and to build online travel communities with characteristics such usefulness and ease of use. Originality/value: There has been a lot of marketing research on eWOM but none has focused on covering eWOM in tourism industry and its impact on tourism destination choice by adding new dimension of eWOM to the theory of planned behavior. This paper seeks to fill this gap. © Emerald Group Publishing Limited.
Panahi B., Moshtaghi N., Torktaz, I., Panahi A., Roy S.
Journal of Proteomics and Bioinformatics (discontinued) (0974276X)(9)pp. 214-216
Eukaryotic NHX transporters are trans-membrane proteins which are vital for cellular homeostasis. Plants vacuolar NHX antiporters have been suggested to be involved in sequestering Na + into vacuoles, thus preventing toxic effects of Na + in the cytoplasm. Primary and secondary structure analysis of NHX antiporter of Leptochloa fusca suggested that this antiporter is a hydrophobic protein containing a significant proportion of alpha helixes. In this study, a three-dimensional structures of NHX antiporter predicted by in silico 3D homology modeling studies. The resulting model was refined by energy minimization, subjected to the quality assessment from both geometric and energetic aspects and was found to be of reasonable quality. Validation of 3D structure was done by plotting Ramachandran plot and calculation of QMEAN score. This predicted information will help in better understanding of mechanisms underlying to salt tolerance in monocot plants and use of this information in protein engineering to improve plants to high salinity conditions. © 2012 Panahi B, et al.
Raoof, J., Kiani, A., Ojani R., Valiollahi R.
Analytical And Bioanalytical Electrochemistry (20084226)(1)pp. 59-66
A carbon paste electrode (CPE) modified by multiwalled carbon nanotubes(MWCNTs) and banana tissue was used for detection of dopamine (DA). The modified electrode show good selectivity toward DA in the presence of ascorbic acid (AA). The electrochemical determination of DA at the surface of modified electrode was investigated by differential pulse voltammetry (DPV). The linear curve was obtained in the range of 10-30 μM. The detection limit (3σ) was 2.09 μM for DA. Also the stability of modified electrode was investigated after 20 days, and results show that the modified has relatively good stability. © 2011 by CEE.
Aghababaei Jazi M., Alamatsaz m.h., M.H.
Pakistan Journal Of Statistics (10129367)(2)pp. 139-157
The family of generalized power series (GPS) distributions contains some known discrete distributions whose zero-inflated and inflated-parameter extensions have been used to model different types of dependent counts in various fields such as insurance, finance, biometrics, etc. However, in such extensions, the inflated parameter has been considered to be a constant value. In this paper, we shall first compare such extended distributions for the Bernoulli case with its mixture, when the inflated parameter is a random variable, in various types of stochastic orderings. Then, we shall investigate modality and divisibility properties of known members of inflated-parameter GPS distributions. Our findings happen to be the same as those for the classic GPS distributions except for the Bernoulli's case. © 2011 Pakistan Journal of Statistics.
Applied Soft Computing (15684946)11(2)pp. 1801-1810
Human face detection plays an important role in a wide range of applications such as face recognition, surveillance systems, video tracking applications, and image database management. In this paper, a novel fuzzy rule-based system for pose, size, and position independent face detection in color images is proposed. Subtractive clustering method is also applied to decide on the numbers of membership functions. In the proposed system, skin-color, lips position, face shape information and ear texture properties are the key parameters fed to the fuzzy rule-based classifier to extract face candidate in an image. Furthermore, the applied threshold on the face candidates is optimized by genetic algorithm. The proposed system consists of two main stages: the frontal/near frontal face detections and the profile face detection. In the first stage, skin and lips regions are identified in HSI color space, using fuzzy schemes, where the distances of each pixel color to skin-color and lips-color clusters are applied as the input and skin-likelihood and lips-like images are produced as the output. Then, the labeled skin and lips regions are presented to both frontal and profile face detection algorithms. A fuzzy rule-based containing the face and lips position data, along with the lips area and face shape are employed to extract the frontal/near frontal face regions. On the other hand, the profile face detection algorithm uses a geometric moments-based ear texture classification to verify its outcomes. The proposed method is tried on various databases, including HHI, Champion, Caltech, Bao, Essex and IMM databases. It shows about 98, 96 and 90% correct detection rates over 783 samples, in frontal, near frontal and profile face images, respectively. © 2010 Elsevier B.V. All rights reserved.
CTIT workshop proceedings series (16821750)37pp. 823-827
In this paper we present and develop a set of algorithms, mostly based on morphological operators, for automatic colonic polyp detection applied to computed tomography (CT) scans. Initially noisy images are enhanced using Morphological Image Cleaning (MIC) algorithm. Then the colon wall is segmented using region growing followed by a morphological grassfire operation. In order to detect polyp candidates we present a new Automatic Morphological Polyp Detection (AMPD) algorithm. Candidate features are classified as polyps and non-polyps performing a novel Template Matching Algorithm (TMA) which is based on Euclidean distance searching. The whole technique achieved 100% sensitivity for detection of polyps larger than 10 mm and 81.82% sensitivity for polyps between 5 to 10 mm and expressed relatively low sensitivity (66.67%) for polyps smaller than 5 mm. The experimental data indicates that our polyp detection technique shows 71.73% sensitivity which has about 10 percent improvement after adding the noise reduction algorithm.
Faghihian h., H., Mousazadeh M.H.
Iranian Journal Of Chemistry And Chemical Engineering (10219986)(3)pp. 121-127
The ability of natural clinoptilolite and its modified forms were studied for removal of PAHs from n-paraffin. Surfactant modified zeolite (SMZ) was obtained by modifying clinoptilolite with hexadecyltrimethylammonium ion. Homoionic forms of zeolite were obtained by ion exchange process using inorganic salts of desirable cations (e.g. Ag+, Fe3+...). Natural clinoptilolite and its cation exchanged forms show small affinity toward PAHs, due to their hydrophil nature, whereas SMZ removed more than 50 percent of the initial PAHs contents of n-paraffin. The structure of zeolite did not change upon modification. Regeneration of zeolite was performed efficiently with chloroform.
Choi J.-H., Clegg, W., Nichol G.S., Lee S.H., Park Y.C., Habibi, M.H.
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy (13861425)(3)pp. 796-801
The structure of trans-[CrCl2(Me2tn)2]Cl (Me2tn = 2,2-dimethylpropane-1,3-diamine) has been determined by a single-crystal X-ray diffraction study at 150 K. The analysis reveals that there are two independent Cr(III) complex cations in the structure, one with crystallographic inversion symmetry and the other with two-fold rotation symmetry, which are conformational isomers of each other. In both conformations, the chromium atom adopts a distorted octahedral structure with the four nitrogen atoms of two Me2tn ligands occuping the equatorial plane and two chlorine atoms occuping trans-axial positions. The six-membered chelate rings are in stable chair conformations with N-Cr-N angles of 87.03(8)° and 88.99(8)°. The two chelate rings in the centrosymmetric complex cation 1 are anti, while those in the rotation-symmetric complex cation 2 are in syn conformations. The mean Cr-N and Cr-Cl bond lengths are 2.0922 and 2.3253 Å, respectively. The infrared and UV-visible absorption spectra of trans-[CrCl2(Me2tn)2]Cl have also been measured. The resolved band maxima of the electronic d-d spectrum are fitted with a secular determinant for a quartet energy state of the d3 configuration in a tetragonal field including configurational but neglecting spin-orbit coupling. It is confirmed that the nitrogen atoms of the Me2tn ligand have a strong σ-donor character, but the chloro ligand has weak σ- and π-donor properties toward the chromium(III) ion. © 2007 Elsevier B.V. All rights reserved.
Faghihian h., H., Vafadar M., Tavakoli, T.
Iranian Journal Of Chemistry And Chemical Engineering (10219986)(2)pp. 19-25
The objective of this research is to find an economically attractive alternative method for hydrodesulfurization of petroleum fractions and to select a suitable adsorbent for this process. Deep desulfurization of transportation fuels (gasoline, diesel, and jet fuels) is being mandated by governments and is also needed for future fuel cell applications. However, it is extremely difficult and costly to achieve with current technology, which requires catalytic reactors operated at high pressure and temperature. Zeolites are a family of crystalline aluminosilicate minerals. About fifty natural zeolites are now known and more than one hundred and fifty have been synthesized. Clinoptilolite is a naturally occurring zeolite, formed by the diversification of volcanic ash in lake and marine waters millions of years ago. It is the most researched of all zeolites and is widely regarded as the most useful. It is an abundant natural zeolite. We show that Hg+2 and Ag+ clinoptilolite can adsorb sulfur compounds from commercial fuels selectively and with high capacities. The desulfurization of 83.60 % by Ag+ clinoptilolite at liquid to solid ratio of 50/100 gr.ml-1, 353 K,and flow rate of 3.0 ml.min-1 was obtained.
Zafar M., Najeeb S., Khurshid Z., Vazirzadeh M., Zohaib S., Najeeb B., Sefat F.
Materials (19961944)(2)
Electrospinning is a versatile technique that has gained popularity for various biomedical applications in recent years. Electrospinning is being used for fabricating nanofibers for various biomedical and dental applications such as tooth regeneration, wound healing and prevention of dental caries. Electrospun materials have the benefits of unique properties for instance, high surface area to volume ratio, enhanced cellular interactions, protein absorption to facilitate binding sites for cell receptors. Extensive research has been conducted to explore the potential of electrospun nanofibers for repair and regeneration of various dental and oral tissues including dental pulp, dentin, periodontal tissues, oral mucosa and skeletal tissues. However, there are a few limitations of electrospinning hindering the progress of these materials to practical or clinical applications. In terms of biomaterials aspects, the better understanding of controlled fabrication, properties and functioning of electrospun materials is required to overcome the limitations. More in vivo studies are definitely required to evaluate the biocompatibility of electrospun scaffolds. Furthermore, mechanical properties of such scaffolds should be enhanced so that they resist mechanical stresses during tissue regeneration applications. The objective of this article is to review the current progress of electrospun nanofibers for biomedical and dental applications. In addition, various aspects of electrospun materials in relation to potential dental applications have been discussed. © 2016 by the authors.
Pahlevanzadeh B., Mousavi M.
Iranian Economic Review (10266542)(1)pp. 1-15
In recent years, the studies of location play a key role in success and stability of economic activities. Location studies are under consideration in both national and international levels. Meanwhile, identification of goals and methods of solving location problems have significant importance. The purpose of this paper is to examine spatial distribution of economic activities in 14 zones of Esfahan. In parallel to this approach, existing activities in Esfahan have been classified homogeneously into 32 activity groups. Then, the zones with diversification and specialization have been studied, as well as effective factors on location of these activities by using of a regression model. Considering locational data in this survey, the specified model, have been estimated by spatial econometric methods to consider spatial effects in model as far as possible. Based on research results, both specialization and diversification factors are effective factor on location of economic activities in Esfahan. The results show that contiguity factor is effective on distribution of activities; therefore spatial relationship exists among the various zones of Esfahan. © 2015, University of Teheran. All rights reserved.
Jahandar, M., Zarrabi, A., Shokrgozar m.a., M.A., Mousavi, H.
Materials Research Express (20531591)(12)
Superparamagnetic iron oxide nanoparticles (SPIONs) with an average size of 10 nmhave been successfully synthesized by the polyol method. Then, hyperbranched polyglycerol (HPG) branches have been introduced on the surface of SPIONs through ring opening polymerization of glycidol as a biocompatible surface modifier with a more hydrophilic nature than other biomedical polymers. The as-synthesized SPION-HPGs were analyzed by FT-IR, CHNS and TGAanalysis which all exhibited the successfulHPGgrafting onto the SPION surface. The anticancer herbal drug, curcumin, was loaded on the resultant nanocarrier. TheMTTassay demonstrated the non-cytotoxicity effect of SPION-HPGs and the low cytotoxicity effect of curcumin at low concentrations on L929 and MCF-7 cell lines as normal and cancerous cells, respectively. Moreover, these nanoparticles exhibited an improved effect as a contrast agent in magnetic resonance imaging. Thus, it is concluded that SPIONHPGhas the potential to be used in theranostics applications due to its simultaneous drug delivery and imaging capabilities. © 2015 IOP Publishing Ltd.
Moeiniafshari A.-A., Zarrabi, A., Bordbar, A.
Food Hydrocolloids (0268005X)pp. 1-6
Casein is composed of four types of protein α s1, α s2, β and k{hooktop} in ratios of 4:1:4:1. β-casein has a lower critical micelle concentration than the other three types which results in its higher stability in the aqueous medium. The self-assembly, the unique feature of β-casein, helps to form the micelles without the need to emulsifiers and stabilizers, which they may have some adverse effects on the body. Naringenin is the main flavone in grapefruit that has several pharmacological properties such as antioxidant, anticancer and anti-inflammatory effects. Since naringenin is hydrophobic, its solubility in water could be raised by β-casein. In this study, the binding of naringenin with bovine β-casein is investigated at neutral pH 7.0. For this purpose, fluorescence spectroscopy technique was used. By using fluorescence quenching methods, the Stern-Volmer quenching constant (KSV), the number of binding sites (n), binding constants (Kb) and thermodynamic parameters δH, δG and δS were calculated at 298, 303 and 308K. For estimating the distance between donor (β-casein) and acceptor (naringenin), fluorescence resonance energy transfer was used. © 2015 Elsevier Ltd.
Tamadonpour M., Yavari H.
European Physical Journal Plus (21905444)(9)
The effect of spin-independent hybridization potential and spin–orbit coupling on two-band superconductor with equal-time s-wave interband pairing order parameter is investigated theoretically. To study symmetry classes in two-band superconductors, the Gor’kov equations are solved analytically. By defining spin-singlet and spin-triplet s-wave order parameter due to two-band degree of freedom, the symmetry classes of Cooper pair are studied. For spin singlet case, it is shown that spin-independent hybridization generates Cooper pair that belongs to even-frequency spin singlet even-momentum even-band parity (ESEE) symmetry class for both intraband and interband pairing correlations. For spin-triplet order parameter, intraband pairing correlation generates odd-frequency spin triplet even-momentum even-band parity (OTEE) symmetry class, whereas interband pairing correlation generates even-frequency spin-triplet even-momentum odd-band parity (ETEO) class. For the spin singlet, spin–orbit coupling generates pairing correlation that belongs to odd-frequency spin-singlet odd-momentum even-band parity (OSOE) symmetry class and even-frequency spin-singlet even-momentum even-band parity (ESEE) for intraband and interband pairing correlation, respectively. In the spin-triplet case for intraband and interband correlation, spin–orbit coupling generates even-frequency spin-triplet odd-momentum even-band parity (ETOE) and even-frequency spin-triplet even-momentum odd-band parity (ETEO), respectively. Our results are in agreement with previous experimental and theoretical studies. © 2021, The Author(s), under exclusive licence to Società Italiana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature.
Aramesh-boroujeni, Z., Zahra Asadi A.
Iranian Journal Of Chemistry And Chemical Engineering (10219986)(4)pp. 1042-1053
The electro-oxidation of venlafaxine (VEN) was investigated at a carbon paste electrode, the modified electrode by NiO/Graphene Reduce (GR) nanocomposite. The structure and morphological aspects of the nanocomposite were approved using FE-SEM, EDAX, and FT-IR. The electrode reaction process was a diffusion-controlled one and the electrochemical oxidation involved two electrons transferring and two protons participating. Under the optimized conditions, the electro-oxidation peak currents were linearly dependent on the concentration of VEN in the concentration range from 1.0-40.0 μM with the limit of detection (S/N=3) as 0.05 μM. The proposed method has been successfully applied in the electrochemical quantitative determination of VEN content in real samples and the determination, results could meet the requirement of the quantitative determination. © 2021, Iranian Institute of Research and Development in Chemical Industries. All rights reserved.
Moghadam, B.H., Golestani F., Bagheri, R., Cheraghloo, N., Eskandari M., Wong, A., Nordvall, M., Suzuki, K., Pournemati p.,
Cancers (20726694)(17)
Background: Chronic inflammation associated with breast cancer (BC) poses a major challenge in care management and may be ameliorated by physical activity. This randomized controlled trial assessed the effects of a 12-week high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on inflammatory markers, body composition, and physical fitness in BC survivors (BCS). Methods: Forty BCS (age = 57 ± 1 years; body mass [BM] = 74.8 ± 1.5 kg; VO2peak = 20.8 ± 2.1 mL·kg−1·min−1 ) were randomly assigned to three groups: HIIT (n = 15), MICT (n = 15), or control (CON; n = 15). The intervention groups (HIIT and MICT) performed their respective exercise protocols on a cycle ergometer 3 days/week for 12 weeks while the CON group maintained their current lifestyle. Baseline and post-intervention assessments included body composition (BM, fat mass (FM), lean mass (LM)), physical fitness (VO2peak, lower body strength (LBS), upper body strength (UBS)), and serum concentrations of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), leptin, and adiponectin. Results: Both intervention groups significantly (p < 0.05) decreased BM (HIIT = −1.8 kg, MICT = −0.91 kg), FM (HIIT = −0.81 kg, MICT = −0.18 kg), TNF-α (HIIT = −1.84 pg/mL, MICT = −0.99 pg/mL), IL-6 (HIIT = −0.71 pg/mL, MICT = −0.36 pg/mL), leptin (HIIT = −0.35 pg/mL, MICT = −0.16 pg/mL) and increased VO2peak (HIIT = 0.95 mL·kg−1·min−1, MICT = 0.67 mL·kg−1·min−1 ), LBS (HIIT = 2.84 kg, MICT = 1.53 kg), UBS (HIIT = 0.53 kg, MICT = 0.53 kg), IL-10 (HIIT = 0.63 pg/mL, MICT = 0.38 pg/mL), and adiponectin (HIIT = 0.23 ng/mL, MICT = 0.1 ng/mL) compared to baseline. The changes in BM, FM, TNF-α, leptin, and LBS were significantly greater in HIIT compared to all other groups. Conclusions: Our findings indicate that compared to the often-recommended MICT, HIIT may be a more beneficial exercise therapy for the improvement of inflammation, body composition and LBS in BCS; and consequently, merits long-term study. © 2021 by the authorsLicensee MDPI, Basel, Switzerland.
Miralaei N., Majd A., Ghaedi, K., Peymani, M., Safaei M.
Cancer Medicine (20457634)(18)pp. 6428-6441
Introduction: The AURKA gene encodes a protein kinase involved in cell cycle regulation and plays an oncogenic role in many cancers. The main objective of this study is to analyze AURKA expression in 13 common cancers and its role in prognostic and drug resistance. Method: Using the cancer genome atlas (TCGA) as well as CCLE and GDSC data, the level of AURKA gene expression and its role in prognosis and its association with drug resistance were evaluated, respectively. In addition, the expression level of AURKA was assessed in colorectal cancer (CRC) and gastric cancer (GC) samples. Besides, using Gene Expression Omnibus (GEO) data, drugs that could affect the expression level of this gene were also identified. Results: The results indicated that the expression level of AURKA gene in 13 common cancers increased significantly compared to normal samples or it survived poorly (HR >1, p < 0.01) in lung, prostate, kidney, bladder, and uterine cancers. Also, the gene expression data showed increased expression in CRC and GC samples compared to normal ones. The level of AURKA was significantly associated with the resistance to SB 505124, NU-7441, and irinotecan drugs (p < 0.01). Eventually, GEO data showed that JQ1, actinomycin D1, and camptothecin could reduce the expression of AURKA gene in different cancer cell lines (logFC < 1, p < 0.01). Conclusion: Increased expression of AURKA is observed in prevalent cancers and associated with poor prognostic and the development of drug resistance. In addition, some chemotherapy drugs can reduce the expression of this gene. © 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
