Type:

New jatrophane diterpenes from Euphorbia osyridea with proapoptotic effects on ovarian cancer cells

Journal: Phytochemistry Letters (18767486)Year: 16 June 2015Volume: 12Issue: Pages: 302 - 307

Ghanadian M.Saeidi H.^a Aghaei M. Rahiminejad M.R. Ahmadi E. Ayatollahi A.M. Choudhary M.I. Bahmani B.

a :University of Isfahan - IRAN(IR) - Isfahan

DOI:10.1016/j.phytol.2015.04.011Language: English

Abstract

Abstract A dichloromethane-acetone extract of Euphorbia osyridea Bioss. (Syn. Euphorbia lateriflora Schumach. & Thonn), a spurge endemic to Iran and West Africa, afforded three new jatrophane diterpenes belonging to the 2,3,5,7,8,9,14,15-octahydroxy-jatropha-6(17),11E-diene class along with three known triterpenes. Structures of these compounds were elucidated by spectroscopic methods, especially 2D NMR analyses. Biological effects of these compounds were analyzed by performing MTT and annexin V-FITC and PI staining assays against different cancer cell lines. Results showed that 2,3,5,7,8,9,14,15-octahydroxy-jatropha-6(17), 11E-diene derivatives (1-3) inhibit the cell proliferation through apoptosis in the Caov-4 and OVCAR-3 cancer cell lines. © 2015 Phytochemical Society of Europe.