Synthesis and characterization of Bis-quinazolines from linear tetra-amines involving 2-(aminomethyl)benzenamine with aldehydes

Abstract

Three tetra-amine compounds 2-((2-(2-aminobenzylamino)ethylamino)methyl) benzenamine (L1), 2-((3-(2-aminobenzylamino)propylamino)methyl) benzenamine (L2), and 2-((4-(2-aminobenzylamino)butylamino)methyl) benzenamine (L3) were synthesized and then their reaction with 2-hydroxybenzaldehyde, 2-nitrobenzaldehyde, and 2-hydroxy-3-methoxybenzaldehyde were investigated. Treatment of L1, L2, and L3 with the former aldehydes gave derivatives of quinazolines in a good yield. The products have been studied with IR, 1H NMR, 13C NMR, COSY, HMQC, and microanalysis. © 2013 HeteroCorporation.