Type: Article

A simple and efficient large-scale synthesis of 3-hydroxyphthalans via oxa-Pictet-Spengler reaction catalyzed by nanosilica sulfuric add

Journal: Tetrahedron Letters (00404039)Year: 2011Volume: 52Issue: 11Pages: 1213 - 1216

Khorsandi Z. Khosropour A.R.Mirkhani V.^aMohammadpoor Baltork I.^aMoghadam M.^aTangestaninejad S.^a

a :University of Isfahan - IRAN(IR) - Isfahan

DOI:10.1016/j.tetlet.2011.01.037Language: English

Abstract

Nanosilica sulfuric acid is found to be a new, powerful and reusable heterogeneous catalyst for the rapid synthesis of 3-hydroxyphthalans via condensation of aromatic aldehydes and 3-hydroxybenzyl alcohols under conventional heating and microwave irradiation. Scale-up preparation of these heterocycles is also carried out. (C) 2011 Published by Elsevier Ltd.