Type: Article

Diastereoselective Synthesis of Pyrazolines using a Bifunctional Bronsted Acidic Ionic Liquid under Solvent-Free Conditions

Journal: ADVANCED SYNTHESIS & CATALYSIS (16154150)Year: 2012Volume: 354Issue: 16Pages: 3095 - 3104

Safaei S.Mohammadpoor Baltork I.^a Khosropour A.R.Moghadam M.^aTangestaninejad S.^aMirkhani V.^a

a :University of Isfahan - IRAN(IR) - Isfahan

DOI:10.1002/adsc.201200191Language: English

Abstract

An efficient protocol for the excellent diastereoselective synthesis of pyrazolines via a three-component reaction of aldehydes, hydrazines and dimethyl acetylenedicarboxylate (DMAD) in the presence of a bifunctional Bronsted acidic ionic liquid as a reusable catalyst under solvent-free conditions is reported. Easy work-up, short reaction times, high yields of the products and an environmentally benign procedure avoiding toxic organic solvents are other significant features of this method.