Type: Article

Diastereoselective Synthesis of Pyrazolines using a Bifunctional Bronsted Acidic Ionic Liquid under Solvent-Free Conditions

Journal: ADVANCED SYNTHESIS & CATALYSIS (16154150)Year: 2012Volume: 354Issue: 16Pages: 3095 - 3104

Safaei, Shirin Mohammadpoor-Baltork, Iraj Khosropour, Ahmad R.Safaei S.Mohammadpoor Baltork I.^a Khosropour A.R.Moghadam M.^aTangestaninejad S.^aMirkhani V.^a

a :University of Isfahan - IRAN(IR) - Isfahan

DOI:10.1002/adsc.201200191Language: English

Abstract

An efficient protocol for the excellent diastereoselective synthesis of pyrazolines via a three-component reaction of aldehydes, hydrazines and dimethyl acetylenedicarboxylate (DMAD) in the presence of a bifunctional Bronsted acidic ionic liquid as a reusable catalyst under solvent-free conditions is reported. Easy work-up, short reaction times, high yields of the products and an environmentally benign procedure avoiding toxic organic solvents are other significant features of this method.

Author Keywords

aldehydesdiastereoselectivityheterocyclesionic liquidsmulticomponent reactions

Other Keywords

ELECTRON-DEFICIENT OLEFINS1,3-DIPOLAR CYCLOADDITIONDERIVATIVESEFFICIENTCATALYSTBENZIMIDAZOLESESTERIFICATIONNITRILIMINESHYDRAZONESANALOGS