Experimental Gerontology (18736815)149
The crosstalk between skeletal muscles and other tissues such as bones is typically established via the secretion of myokines and myomiRs induced by exercise training (ET). The present study aimed at evaluating the relationship between changes made by different ET modes and intensities in myomiRs, osteomiRs, and other myogenic and osteogenic biomarkers in old male Wistar rats. To this end, a total number of 50 old (23 months of age) male Wistar rats were randomly assigned to four experimental groups, namely, moderate-intensity endurance training (MIET), high-intensity endurance training (HIET), moderate-intensity resistance training (MIRT), high-intensity resistance training (HIRT), and control (CON), each one comprised of 10 subjects. The study findings revealed positive correlations between myomiRs (i.e., miR-1) and myomiR-204a (r = 0.725; p = 0.042), myomiR-1, and runt-related transcription factor 2 (RUNX2) osteogenic marker (r = 0.869; p = 0.025) in the HIET group, myomiR-206 and peroxisome proliferator-activated receptor gamma (PPARγ) (r = 0.908; p = 0.012) in the MIRT group, myomiR-133a and osteomiR-133a (r = 0.971; p = 0.005) in the MIET group, myomiR-133a and osteomiR-204a in the MIRT group (r = 0.971; p = 0.004), and myomiR-133a and RUNX2 gene expression in the HIET group (r = 0.861; p = 0.027). It was concluded that myomiRs involved in myoblast-osteoblast differentiation might not alone regulate the myogenic and osteogenic targets in response to different modes and intensities of ET treatments. © 2021
