Articles
Atashafrooz M.,
Delouei A.A.,
Sajjadi H.,
Yan W.-M.,
Behineh, E.S.,
Hashemikamangar, S.S.,
Ghaffarpasand o., O.,
Nourmohammadi abadchi, A.,
Afshari, A.,
Drewnick, F.,
Fesharaki, H.M.,
Aghamir, Z.S.,
Hosseinibalam, F.,
Kamali, F.,
Gallavardin, S.,
Fachinger, J.,
Borrmann, S. Publication Date: 2025
International Journal of Thermofluids (26662027)pp. 215-235
The main goal of this research is to examine the interacting impacts of buoyancy force, thermal radiation, nanoparticles concentration and magnetic force on thermal behaviors of mixed convection alumina-water nanofluid flow in an inclined Exhaust geometry. This geometry includes two inclined forward facing steps (FFSs) which are symmetrically located on the top and bottom walls of an inclined channel. These inclined steps are modeled in Cartesian coordinates by applying the embedded boundary method. The governing equations are numerically solved by means of the finite volume method and SIMPLE algorithm. The Rosseland approximation is adopted to calculate the radiative heat transfer term in the energy equation. Influences of Brownian motion on the effective thermal conductivity and viscosity of nanofluid is considered by applying the KKL correlation. The results are shown for various values of Grashof number (Gr = 0 − 30, 000), the Exhaust inclination angle (γ = 0° − 90°), radiation parameter (Rp = 0 − 1), Hartmann number (Ha = 0 − 200) and alumina nanoparticles concentration (ξ = 0 − 0.04). The predicted results indicate that the Gr, γ, Rp and Ha parameters have a considerable impact on the temperature distributions inside the bottom half domain of the Exhaust, whilst the influence of ξ parameter on these distributions is very small and ignorable. Furthermore, the maximum value of total heat transfer rate happens in the vertical Exhaust with highest values of Gr, Rp, Ha and ξ parameters (γ = 90°, Gr = 30, 000, Rp = 1, Ha = 200, ξ = 0.04). Comparing the numerical results of the present study with the results of other benchmark problems shows excellent agreement. © 2025
Nasier-Hussain M.,
Samanje J.N.,
Mokhtari K.,
Nabi-Afjadi M.,
Fathi Z.,
Hosseini, A.,
Bahreini E.,
Shakour, N.,
Afshar, H.,
Behrouz b., ,
Yazdanmehr m., M.,
Hoseinpoor, S.,
Adibi, N.,
Amini k., ,
Jalali asadabadi, S.,
Rajabian, F.,
Afshari, A.,
Shakhniya, F.,
Nourmohammadi abadchi, A.,
Azimi, S.G.,
Rohani, S.,
Ghasemzadeh, M.,
Iranshahi, M.,
Saberi, F.,
Ghasemi n., ,
Rezvanian, M.,
Sadeghi-aliabadi, H.,
Hadizadeh, F. Publication Date: 2025
BMC Gastroenterology (1471230X)(1)pp. 3508-3525
Background and aim: Helicobacter pylori (H.pylori), a gram-negative bacterial pathogen associated with an increased risk of gastric cancer. This study investigates potential factors in the incidence of gastric cancer in patients with H.pylori, including oxidative stress, inflammatory biomarkers, serum pepsinogens (PG) of I and II, and PG-I/PG-II ratio. Methods: The study comprised individuals with Helicobacter pylori (H.pylori) infection, gastric cancer patients, and healthy individuals. Biochemical parameters such as FBS (fasting blood sugar), lipid profile, and liver and kidney functional factors were evaluated using colorimetric techniques. Oxidative markers such as total oxidant status (TOS) and malondialdehyde (MDA) were quantified through colorimetric methods. IL-8, PG-II, and PG-II levels were also determined using the ELISA technique. Results: Individuals with H. pylori infection exhibited elevated levels of IL-8 (940.5 ± 249.7 vs. 603.4 ± 89.1 pg/ml, P < 0.0001) and oxidative species (5.47 ± 0.7 vs. 1.64 ± 0.7 nM, P < 0.05) compared to gastric cancer patients, who, despite having lower levels of IL-8 and oxidative species, showed higher levels of MDA. H.pylori patients exhibited significantly higher levels of PG-I (7.28 ± 2.1 vs. 2.61 ± 1.4 ng/ml, P < 0.001), PG-II (3.21 ± 1 vs. 2.6 ± 0.6 ng/ml, P < 0.001), and the PG-I/PG-II ratio (2.27 ± 1.2 vs. 1 ± 0.4, P < 0.001) compared to gastric cancer patients. The findings were substantiated using various data analysis platforms such as Gene Expression Profiling Interactive Analysis (GEPIA), UALCAN (The University of ALabama at Birmingham CANcer data analysis), cBioPortal, and TIMER (Tumor IMmune Estimation Resource). These parameters could serve as potential diagnostic biomarkers for screening and therapeutic interventions based on the cut-off values derived from ROC (receiver operating characteristic) curves for IL-8, PGI, PGII, and PGI/PGII across the three groups. Conclusions: IL-8, PGI, PGII, and PGI/PGII parameters could serve as potential diagnostic markers for the screening and treatment of gastric conditions. © The Author(s) 2024.
