Articles
Scientific Reports (20452322)15(1)
The cubic ferromagnetic Laves phase intermetallic compound is a promising candidate for aerospace, defense, and advanced engineering applications due to its thermal stability and reliable elastic properties under pressure. However, two key gaps persist: discrepancies between theoretical and experimental elastic constants, and a lack of systematic pressure-dependent investigations. This study addresses these gaps, highlighting ’s exceptional thermal stability, with melting temperatures rising linearly under pressure, its near-isotropic compressive behavior, and mild anisotropy in shear and Young’s moduli. Using density functional theory, elasticity theory, and AI-driven neural networks, we systematically analyzed the elasticity and stability of the system under pressure and temperature. A rigorous energy-based methodology resolves the first gap, setting a benchmark for cubic systems. To address the second gap, we analyzed mechanical stability up to 20 GPa via the Born stability criteria, finding consistent increases in elastic constants, bulk modulus, and Young’s modulus under compression. Phonon dispersion and density of states analyses confirm dynamic stability and reveal that low-frequency acoustic modes dominated by Gd atoms drive elastic behavior, reflecting spin-dominated mechanics. Poisson’s ratio shows mild anisotropy, while ductility assessments reaffirm the material’s brittle nature, consistent with Laves phase intermetallics. By integrating advanced computational methods and AI predictions, this work resolves theoretical-experimental discrepancies, establishes a framework for spin-dominated systems, and positions as a benchmark for spin-lattice interactions and anisotropy in next-generation engineering under pressure. © The Author(s) 2025.
Nasier-Hussain M.,
Samanje J.N.,
Mokhtari K.,
Nabi-Afjadi M.,
Fathi Z.,
Hosseini, A.,
Bahreini E.,
Shakour, N.,
Afshar, H.,
Behrouz b., ,
Yazdanmehr m., M.,
Hoseinpoor, S.,
Adibi, N.,
Amini k., ,
Jalali asadabadi, S.,
Rajabian, F.,
Afshari, A.,
Shakhniya, F.,
Nourmohammadi abadchi, A.,
Azimi, S.G.,
Rohani, S.,
Ghasemzadeh, M.,
Iranshahi, M.,
Saberi, F.,
Ghasemi n., ,
Rezvanian, M.,
Sadeghi-aliabadi, H.,
Hadizadeh, F. BMC Gastroenterology (1471230X)(1)pp. 3508-3525
Background and aim: Helicobacter pylori (H.pylori), a gram-negative bacterial pathogen associated with an increased risk of gastric cancer. This study investigates potential factors in the incidence of gastric cancer in patients with H.pylori, including oxidative stress, inflammatory biomarkers, serum pepsinogens (PG) of I and II, and PG-I/PG-II ratio. Methods: The study comprised individuals with Helicobacter pylori (H.pylori) infection, gastric cancer patients, and healthy individuals. Biochemical parameters such as FBS (fasting blood sugar), lipid profile, and liver and kidney functional factors were evaluated using colorimetric techniques. Oxidative markers such as total oxidant status (TOS) and malondialdehyde (MDA) were quantified through colorimetric methods. IL-8, PG-II, and PG-II levels were also determined using the ELISA technique. Results: Individuals with H. pylori infection exhibited elevated levels of IL-8 (940.5 ± 249.7 vs. 603.4 ± 89.1 pg/ml, P < 0.0001) and oxidative species (5.47 ± 0.7 vs. 1.64 ± 0.7 nM, P < 0.05) compared to gastric cancer patients, who, despite having lower levels of IL-8 and oxidative species, showed higher levels of MDA. H.pylori patients exhibited significantly higher levels of PG-I (7.28 ± 2.1 vs. 2.61 ± 1.4 ng/ml, P < 0.001), PG-II (3.21 ± 1 vs. 2.6 ± 0.6 ng/ml, P < 0.001), and the PG-I/PG-II ratio (2.27 ± 1.2 vs. 1 ± 0.4, P < 0.001) compared to gastric cancer patients. The findings were substantiated using various data analysis platforms such as Gene Expression Profiling Interactive Analysis (GEPIA), UALCAN (The University of ALabama at Birmingham CANcer data analysis), cBioPortal, and TIMER (Tumor IMmune Estimation Resource). These parameters could serve as potential diagnostic biomarkers for screening and therapeutic interventions based on the cut-off values derived from ROC (receiver operating characteristic) curves for IL-8, PGI, PGII, and PGI/PGII across the three groups. Conclusions: IL-8, PGI, PGII, and PGI/PGII parameters could serve as potential diagnostic markers for the screening and treatment of gastric conditions. © The Author(s) 2024.
