دکتر سعید جلالی اسدآبادی

Nasier-Hussain M., Samanje J.N., Mokhtari K., Nabi-Afjadi M., Fathi Z., Hosseini, A., Bahreini E., Shakour, N., Afshar, H., Behrouz b., , Yazdanmehr m., M., Hoseinpoor, S., Adibi, N., Amini k., , Jalali asadabadi, S., Rajabian, F., Afshari, A., Shakhniya, F., Nourmohammadi abadchi, A., Azimi, S.G., Rohani, S., Ghasemzadeh, M., Iranshahi, M., Saberi, F., Ghasemi n., , Rezvanian, M., Sadeghi-aliabadi, H., Hadizadeh, F.

Publication Date: 2025

BMC Gastroenterology (1471230X)(1)pp. 3508-3525

Background and aim: Helicobacter pylori (H.pylori), a gram-negative bacterial pathogen associated with an increased risk of gastric cancer. This study investigates potential factors in the incidence of gastric cancer in patients with H.pylori, including oxidative stress, inflammatory biomarkers, serum pepsinogens (PG) of I and II, and PG-I/PG-II ratio. Methods: The study comprised individuals with Helicobacter pylori (H.pylori) infection, gastric cancer patients, and healthy individuals. Biochemical parameters such as FBS (fasting blood sugar), lipid profile, and liver and kidney functional factors were evaluated using colorimetric techniques. Oxidative markers such as total oxidant status (TOS) and malondialdehyde (MDA) were quantified through colorimetric methods. IL-8, PG-II, and PG-II levels were also determined using the ELISA technique. Results: Individuals with H. pylori infection exhibited elevated levels of IL-8 (940.5 ± 249.7 vs. 603.4 ± 89.1 pg/ml, P < 0.0001) and oxidative species (5.47 ± 0.7 vs. 1.64 ± 0.7 nM, P < 0.05) compared to gastric cancer patients, who, despite having lower levels of IL-8 and oxidative species, showed higher levels of MDA. H.pylori patients exhibited significantly higher levels of PG-I (7.28 ± 2.1 vs. 2.61 ± 1.4 ng/ml, P < 0.001), PG-II (3.21 ± 1 vs. 2.6 ± 0.6 ng/ml, P < 0.001), and the PG-I/PG-II ratio (2.27 ± 1.2 vs. 1 ± 0.4, P < 0.001) compared to gastric cancer patients. The findings were substantiated using various data analysis platforms such as Gene Expression Profiling Interactive Analysis (GEPIA), UALCAN (The University of ALabama at Birmingham CANcer data analysis), cBioPortal, and TIMER (Tumor IMmune Estimation Resource). These parameters could serve as potential diagnostic biomarkers for screening and therapeutic interventions based on the cut-off values derived from ROC (receiver operating characteristic) curves for IL-8, PGI, PGII, and PGI/PGII across the three groups. Conclusions: IL-8, PGI, PGII, and PGI/PGII parameters could serve as potential diagnostic markers for the screening and treatment of gastric conditions. © The Author(s) 2024.

The effect of feedback-based education on self-efficacy and treatment adherence in elderly diabetic patients after surgery visiting the hospital; [El efecto de la educación basada en la retroalimentación sobre la autoeficacia y la adherencia al tratamiento en pacientes diabéticos de edad avanzada después de una cirugía que visitan el hospital]

( Article . )

Nabizade M., Mokhtari M., Amin P.H., Rezapour-Nasrabad R., Ladani F.K., Bakhtiari M., Nouzari R., Daman S., Yazdanmehr m., M., Trabelsi, N., Jalali asadabadi, S., Nematollahi, J., Nourmohammadi abadchi, A., Ahmad, I.

Publication Date: 2025

Revista Latinoamericana de Hipertension (18564550)(3)pp. 136-142

2024

Anisotropic mechanical behavior and thermal attributes of antiferromagnetic UX2(X=P, As, Sb) materials: A density functional and elasticity theories study

( Article . )

Ebrahimi-jaberi, R., Jalali asadabadi, S.

Publication Date: 2024

Materials Chemistry and Physics (02540584)312

Nonzero spontaneous electric polarization in metals: novel predictive methods and applications

( Article . Gold • Green )

Rahimi, S., Jalali asadabadi, S., Blaha, P., Jalali-asadabadi, F.

Publication Date: 2024

Scientific Reports (20452322)14(1)