Mohammadian, Manijeh,
Jalouti, Nima,
Yazdanian, A.R.,
Keykha, Elham,
Hajisadeghi, Samira Publication Date: 2025
Frontiers in Oral Health (26734842)
Background and aim: Dentin hypersensitivity (DH) has long been a challenging condition, with many treatment methods showing limited success. However, the emergence of laser therapy, particularly the significant potential of diode laser (DL) and sodium fluoride (NaF) varnish, has sparked new hope. This research is a significant step towards a more effective treatment for DH, aiming to evaluate the promising potential of DL in treating DH, both independently and in combination with fluoride varnish. By delving into this research, you are investing your time in understanding a crucial advancement in the field of dentistry. Methods: A comprehensive search was conducted across the PubMed, Scopus, and Web of Science databases, including studies published up until May 2024. Randomized clinical trials that assessed DH using a visual analog scale (VAS) score were included. Data on participant demographics, treatment types, and VAS scores were extracted by two reviewers. The risk of bias was assessed using the revised Cochrane risk-of-bias instrument for randomized trials (RoB-2). Result: Three studies met the inclusion criteria, comparing NaF varnish, DL, and their combination. Both DL and the combination of DL and NaF varnish were more effective than NaF varnish alone in reducing DH. The combined treatment showed marginally superior outcomes compared to DL alone. Significant reductions in DH were observed across all treatment groups, with the combination therapy demonstrating the most substantial and consistent improvement. Conclusion: Diode laser therapy, particularly when combined with NaF varnish, represents a promising treatment approach for DH, offering superior efficacy over NaF varnish alone. These findings suggest that combination therapy may provide longer-lasting relief, with implications for improving clinical outcomes in DH management. 2025 Mohammadian, Jalouti, Yazdanian, Keykha and Hajisadeghi.
Kavousinejad, Shahab,
Yazdanian, A.R.,
Kanafi, Mohammad Mahboob,
Tahmasebi, Elahe Publication Date: 2024
Diagnostics (20754418)(17)
Lateral cephalometric radiographs are crucial in dentistry and orthodontics for diagnosis and treatment planning. However, their use in forensic identification, especially with burned bodies or in mass disasters, is challenging. AM (antemortem) and PM (postmortem) radiographs can be compared for identification. This study introduces and evaluates a novel algorithm for extracting cranial patterns from digital lateral cephalometric radiographs for identification purposes. Due to the unavailability of AM cephalograms from deceased individuals, the algorithm was tested using pre- and post-treatment cephalograms of living individuals from an orthodontic archive, considered as AM and PM data. The proposed algorithm encodes cranial patterns into a database for future identification. It matches PM cephalograms with AM records, accurately identifying individuals by comparing cranial features. The algorithm achieved an accuracy of 97.5%, a sensitivity of 97.7%, and a specificity of 95.2%, correctly identifying 350 out of 358 cases. The mean similarity score improved from 91.02% to 98.10% after applying the Automatic Error Reduction (AER) function. Intra-observer error analysis showed an average Euclidean distance of 3.07 pixels (SD = 0.73) for repeated landmark selections. The proposed algorithm shows promise for identity recognition based on cranial patterns and could be enhanced with artificial intelligence (AI) algorithms in future studies. © 2024 by the authors.
Vazifehdoust, Soheil,
Shalizar-Jalali, Ali,
Nourani, Mohammad Reza,
Moosazadeh Moghaddam M.,
Yazdanian, A.R. Publication Date: 2024
Veterinary Research Forum (20088140)(9)
This study aimed to investigate the effects of zoledronic acid (ZA) and antibacterial CM11 peptide on the osteoinduction and antibacterial properties of bioactive glass (BG). The bioactive glass/gelatin (BG/Gel) composite was synthesized using the sol-gel method. The 2-x minimum inhibitory concentration of the peptide and 4.00 mg mL-1 of ZA were added to the BG/Gel during fabrication. The BG/Gel composite morphological and structural characteristics and anti-bacterial activities were analyzed using Fourier transform infra-red spectroscopy, scanning electron microscopy and disk diffusion test, respectively. The release of the peptide and ZA from BG/Gel was measured using ultra-violet spectroscopy. After 14 days, the effects of the peptide/ ZA-containing BG/Gel (PZ-BG/Gel) on the growth and differentiation of mesenchymal stem cells were evaluated using 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide, calcium and alkaline phosphatase assays, immunocytochemical staining for osteocalcin (OCN) and real-time polymerase chain reaction for OCN, type I collagen, bone morphogenetic protein 2 and Runt-related transcription factor-2 genes. The disk diffusion test showed the anti-microbial activity of the scaffold against multi-drug-resistant isolates of Pseudomonas aeruginosa and Staphylococcus aureus. Analyses showed a significantly higher level of stem cells differentiation into the osteo-genic cells in PZ-BG/Gel scaffold compared to BG/Gel scaffold alone. Accordingly, osteoblast markers were significantly increased in comparison with the control. In conclusion, the osteo-induction and antibacterial properties of BG-based scaffold can be improved using ZA and CM11. © 2024 Urmia University. All rights reserved.
Askari, Mohammad,
Tavaf, Maryam Jadid,
Ghorbani M.,
Yazdanian, A.R.,
Moosazadeh Moghaddam M. Publication Date: 2024
Current Stem Cell Research and Therapy (1574888X)(1)
Background: Major injuries that are caused by trauma and cancer can not be repaired through bone remodeling. The goal of bone regeneration by tissue engineering approaches is to fabricate bone implants in order to restore bone structure and functions. The use of stem cells and polymer scaffolds provides the conditions for tissue regeneration based on tissue engineering. Objective: This study aimed to fabricate a combined matrix of poly(lactide-co-glycolide) (PLGA) and propolis extract, which is a mixture of pollen and beeswax collected by bees from certain plants and has long been used in traditional herbal medicine, to promote the osteogenic differentiation of human adipose-derived mesenchymal stem cells (AD-MSCs). Methods: The scaffold was fabricated through electrospinning and was immersed in a propolis extract solution. Then, AD-MSCs were cultured and differentiated into the osteogenic lineage. The cell viability on the scaffold was evaluated by MTT assay. Osteogenic differentiation of the seeded stem cells was detected by evaluating calcium content, alkaline phosphatase (ALP) activity, and the expression of bonespecific genes. Results: The viability of cells was not affected by propolis-coated and uncoated fabricated scaffolds, while higher calcium content, ALP activity, and expression of RUNX-2, type I collagen, osteocalcin, and osteonectin were observed in cells differentiated on propolis-coated PLGA scaffold on days 7, 14, and 21 of differentiation compared to PLGA scaffold. Conclusion: The results of this study showed that the presence of propolis in the scaffold could lead to better cell attachment and strengthen the osteoinduction process in stem cells. © 2024 Bentham Science Publishers.
Rahbar, Mahdi,
Pourtarrah, Mojtaba,
Tahmasbi, Elaheh,
Bakhtiari, Afsaneh,
Yazdanian, A.R. Publication Date: 2023
Malta Medical Journal (18133339)(2)
Background and aim As the number of elderly people visiting dental clinics increases, it is essential to have sufficient information on the correct treatment as well as the appropriate treatment plan for these patients. Therefore, the present study aimed at reviewing the most important restorative considerations for the elderly. Method In this systematic review study, databases such as Pubmed, Embase, Web of Science, Scopus, ProQuest, Google scholar, as well as Iranian databases were searched with the keywords of elderly dentistry and restorative considerations. Inclusion criteria were original articles and reviews related to restorative dentistry considerations for the elderly without a time limit and being written in either English or Persian. In order to combine the results of the research, a thematic content analysis method was applied. Results The total number of documents recovered was 4208, the number of duplicate documents was 2042, and the number of documents reviewed was 17. The most important considerations related to the elderly included giving due attention to medical and social conditions, medication use, type of restorative teeth, level of restoration involved, use of dentures, age and gender, oral cancer screening, tooth decay education and prevention, and oral hygiene. The most important considerations related to restorative methods and materials were applying minimally invasive methods such as ART, more durable restorative materials, and giving due attention to the aesthetic and non-aesthetic needs of the elderly in choosing restorative materials. The most important considerations related to dentists were the differences in applying restorative methods and materials by experienced dentists in comparison younger dentists and the rate of referral of elderly people to dental centers. Conclusion The most important dental considerations of the elderly are using minimally invasive methods and restorative materials with easy maintenance which are washable according to their social, economic, medical, gender, and age conditions. It is also necessary to consider the prevention of tooth decay and provide the required training for families and their caregivers in nursing homes. The elderly people are also required to avoid change their dentists frequently to maintain their oral health. © 2023, University of Malta. All rights reserved.
Ramezanalizadeh, Hamed,
Ranjbar R.,
Yazdanian, A.R.,
Tahmasebi, Elahe,
Salesi, Mahmood Publication Date: 2023
Optik (00304026)
Noteworthy, potential materials such as L-cysteine and Ag nanoparticles display promising and favorable features in target applications. In the present study, a novel nanohybrid containing L-cysteine-modified graphene oxide (CysGO) decorated with silver nanoparticles (Ag/CysGO) was facilely fabricated through an ultrasound route and characterized by multiple techniques. The antibacterial activity of CysGO and Ag/CysGO nanomaterials was investigated separately for gram-positive and gram-negative bacteria degradation. Owing to the significant antibacterial properties of Ag nanoparticles, Ag/CysGO demonstrated remarkable antibacterial performance for different bacteria. Ag/CysGO also was utilized for the photocatalytic degradation of MB pollutants to corresponding safe materials. Kinetic evaluations for the photocatalytic degradation of MB over prepared catalysts under visible light illumination have been investigated. Based on the reusability tests, the prepared nanohybrid demonstrates the reusability activity without a substantial activity loss. Overall, Ag/CysGO nanohybrid can be an efficient nanomaterial for environmentally friendly photocatalytic degradation approaches. © 2023 Elsevier GmbH
Tahmasebi, Elahe,
Mohammadi, Mehdi,
Yazdanian, A.R.,
Alam, Mostafa,
Abbasi, Kamyar Publication Date: 2023
Journal of Basic Microbiology (0233111X)(9)
The oral antimicrobial and cytotoxic properties of green synthesized novel titanium dioxide nanoparticles (TiO2 NPs) using Iranian propolis extracts were investigated on oral bacteria and fibroblast cells. In this study, propolis was sampled, and alcoholic extracts were prepared. The TiO2 NPs were biosynthesized using propolis extracts. The synthesized TiO2 NPs were characterized by scanning electron microscope (SEM), X-ray diffraction analysis, energy-dispersive X-ray (EDX), Fourier transform infrared spectroscopy (FTIR), dynamic light scattering, ultraviolet–visible (UV–Vis), transmission electron microscope, Brunauer–Emmett–Teller, and zeta potential. MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide), minimal inhibitory concentration, minimum bactericidal concentration, minimum fungicidal concentration, biofilm formation, and degradation tests were studied to clarify the oral antimicrobial properties of green synthesized TiO2 NPs. According to the FTIR analysis, the propolis extract contained flavonoids and phenolic compounds in addition to TiO2 NPs. Additionally, UV-Vis revealed that intense bands had formed NPs. EDX spectra and SEM images revealed that the stabilizing agent was in perfect quasi-spherical shapes around 21 nm. An EDX spectrum was used to verify the presence of titanium and oxygen. There were no significant cytotoxicity effects. The antibacterial results showed that Pro1TiO2 (Khalkhal sample) had better effects than Pro2TiO2 (Gilan sample) and TiO2 NPs. The present study presents a new process for synthesizing TiO2 NPs from propolis extracts with less toxic effects and user-friendly, eco-friendly, and economical materials. Pro1TiO2 NPs may be considered the best candidate for clinical application. © 2023 Wiley-VCH GmbH.
Moghaddam A.,
Khayatan D.,
Esmaeili Fard Barzegar P.,
Ranjbar R.,
Yazdanian, A.R. Publication Date: 2023
International Journal of Environmental Science and Technology (17351472)(5)
The indirect ingestion of pharmaceuticals in water has been proven to have adverse effects on humans according to a number of studies. Pharmaceutical compounds (PhCs) are found in open waters, and drinking these types of waters primarily from raw sewage and wastewater effluents. Effective pharmaceutical removal during drinking water and wastewater treatment is a crucial part of ensuring that pharmaceuticals are effectively removed. There are various excipients and PhCs that may have chronic effects on different communities. Examples include neuroprotective agents, NSAIDs (nonsteroidal anti-inflammatory drugs), diuretics, and antibiotics. Novel procedures such as biodegradation may assist in minimizing or preventing these effects. There is a correlation between the concentrations of each drug group and the seasons or common diseases in particular areas, which emphasizes the need to eliminate pharmaceutical compounds. Organic compounds are broken down into smaller and simpler molecules through biodegradation, which uses enzymes produced by living microbes. The biodegradation of pharmaceuticals usually removes them from the environment, especially those resistant to hydrolysis and photodegradation. Many microorganisms, including bacteria, fungi, and algae, can perform this function. As a result, they are integral parts of the pharmaceutical degradation in the environment. Also, the degradation of PhCs from pharmaceutical wastewater (PW) can be achieved using various biological processes, such as membrane bioreactors (MBRs), conventional activated sludge treatment (CAS), moving bed biofilm reactors (MBBRs), and constructed wetlands. In this review article, the conventional and advanced methods of removing pharmaceutical compounds from surfaces in recent decade studies (2010–2022) are discussed. © 2023, The Author(s) under exclusive licence to Iranian Society of Environmentalists (IRSEN) and Science and Research Branch, Islamic Azad University.
Yazdanian, A.R.,
Barzegar, Peyman Esmaeili Fard,
Ranjbar R.,
Tahmasebi, Elahe,
Tebyaniyan, Hamid Publication Date: 2023
Veterinary Medicine and Science (20531095)(2)
Background: One of the most common causes of pneumonia is Pseudomonas aeruginosa (P. aeruginosa). As with other microbial pathogens, this bacterium tends to develop resistance to various antibiotics. Amikacin and erythromycin, which are from the aminoglycoside and macrolide antibiotic families, are used to treat respiratory infections caused by P. aeruginosa. Objectives: This study explored whether amikacin, erythromycin or a combination of both works better against P. aeruginosa acute lung infection. Methods: For this study, 32 rats were used. The trachea of rats was exposed aseptically and their lung was infected with P. aeruginosa through trachea. Then, according to the group, they received amikacin, erythromycin or a combination of both for 1 week. Finally, they were euthanised on the 3rd and 7th days post-infection. The macroscopic and microscopic evaluations of the lungs, kidney and liver were performed. The right lung was collected for in vivo bacteriological analysis. Results: The amikacin group (A group) had a statistically significantly lower macroscopic and microscopic scores than the other groups (p < 0.05). In vivo bacteriological test revealed that the A group had significantly lower lung bacterial load (p < 0.05). Conclusions: In summary, it was concluded that amikacin could help alleviate the respiratory infection caused by P. aeruginosa solely, and it was more effective than erythromycin. © 2022 The Authors. Veterinary Medicine and Science published by John Wiley & Sons Ltd.
Seyyed Hajizadeh, Yasamin,
Babapour, Ebrahim,
Harzandi, Naser,
Yazdanian, A.R.,
Ranjbar R. Publication Date: 2023
Evidence-based Complementary and Alternative Medicine (1741427X)
Background. Drug resistance is currently possible anywhere in the world. Due to the discovery of antimicrobials, medicine, and health have made tremendous advances over the past several decades. Aim. This research evaluated the antimicrobial and cytotoxicity effects of green synthesis of copper oxide nanoparticles (CuO NPs) on Lactobacillus acidophilus and human embryonic kidney 293 cells (HEK). Method and Materials. Propolis was sampled and extracted. Green synthesis of CuO NPs was synthesized and characterized using SEM, TEM, DLS, BET, and zeta potential methods. L. acidophilus (ATCC 4356) was used, and the antimicrobial tests were carried out at different concentrations (10≥ mg/ml). Moreover, the cytotoxicity was evaluated using an MTT assay on human embryonic kidney 293 cells (HEK). Results. Synthesized CuO NPs using propolis extracts from Khalkhal (sample 1) and Gillan (sample 2) showed -13.2 and -14.4 mV, respectively. The hydrodynamic sizes of well-dispersed samples 1 and 2 were 3124.9 nm and 1726.7 nm, respectively. According to BET analysis, samples 1 and 2 had 5.37 and 8.45 m2/g surface area, respectively. The surface area was decreased due to the addition of propolis extract, and the pore size was increased. CuO NPs of samples 1 and 2 were visible on SEM images with diameters ranging from 75 to 145 nm and 120 to 155 nm, respectively. Based on TEM analysis, the size of CuO particles was increased in samples 1 and 2. CuO NPs particles had narrow size distributions with evenly dispersed NPs on all sides. The cell viability of the CuO NPs of samples 1 and 2 after 24, 48, and 72 hours was greater than 50%. As a result of the MIC and MBC tests, it was determined that samples 1 and 2 had the same effect against L. acidophilus (0.0024 mg/ml). Biofilm formation and degradation of sample 1 were more efficient against L. acidophilus. Conclusion. There was no evidence of cytotoxicity in the samples. In addition, results showed that the green synthesized CuO NPs from Khalkhal propolis were effective against L. acidophilus. Thus, the green synthesized CuO NPs from Khalkhal propolis were the best candidates for clinical application. © 2023 Yasamin Seyyed Hajizadeh et al.
Yazdanian, A.R.,
Rostamzadeh, Pouya,
Alam, Mostafa,
Abbasi, Kamyar,
Tahmasebi, Elahe Publication Date: 2022
AMB Express (21910855)(1)
Dental caries and oral infections have become a widespread issue in the modern world. This study aimed to investigate the antibacterial, antifungal, and cytotoxicity characteristics of the extracts of Echinacea purpura, Arctium lappa, and the essential oil of Zataria multiflora as a potential herbal mouthwash. The essential oil of Z. multiflora leaves and the extracts of E. purpurea and A. lappa roots were prepared. The characterization was carried out by GC-MS and also, total phenol and flavonoid were assed for all three samples. The antimicrobial and anti-biofilm effects were evaluated against Streptococcus mutans, Streptococcus mitis, Streptococcus salivarius, Lactobacillus acidophilus, Escherichia coli, Staphylococcus aureus, and Candida albicans. The cytotoxic effect of the samples was evaluated on HEK 293 and HDFa cells by MTT test. Thymol and carvacrol contents in EO of Z. multiflora were measured at 31% and 42.2%, respectively. A. lappa had the lowest total phenolic and flavonoid value among the samples. On the other hand, the total phenolic content of Z. multiflora and the total flavonoid content of E. purpurea were the highest. The MIC values of Zataria, Arctium, and Echinacea against S. mutans were 0.011% v/v, 187.5 mg/ml, and 93.75 mg/ml, while MBC were 0.011% v/v, 375 mg/ml, and 187.5 mg/ml, respectively. The formulation showed bactericidal activity against S. mutans in the concentration of 5.86 mg/ml for Echinacea and Burdock extracts and 0.08 µl/ml for EO of Zataria. The formulation significantly affected microbial biofilm formation and induced biofilm degradation. The cell viability percentages were higher than 50% during 24 and 48 h. The formulation had a significant antimicrobial effect on cariogenic bacteria and C. albicans, with the lowest cytotoxic effects. Therefore, this formulation can be an appropriate candidate for mouthwash. © 2022, The Author(s).
Yazdanian, A.R.,
Alam, Mostafa,
Abbasi, Kamyar,
Rahbar, Mahdi,
Farjood, Amin Publication Date: 2022
Frontiers in Bioengineering and Biotechnology (22964185)
The state-of-the-art approach to regenerating different tissues and organs is tissue engineering which includes the three parts of stem cells (SCs), scaffolds, and growth factors. Cellular behaviors such as propagation, differentiation, and assembling the extracellular matrix (ECM) are influenced by the cell’s microenvironment. Imitating the cell’s natural environment, such as scaffolds, is vital to create appropriate tissue. Craniofacial tissue engineering refers to regenerating tissues found in the brain and the face parts such as bone, muscle, and artery. More biocompatible and biodegradable scaffolds are more commensurate with tissue remodeling and more appropriate for cell culture, signaling, and adhesion. Synthetic materials play significant roles and have become more prevalent in medical applications. They have also been used in different forms for producing a microenvironment as ECM for cells. Synthetic scaffolds may be comprised of polymers, bioceramics, or hybrids of natural/synthetic materials. Synthetic scaffolds have produced ECM-like materials that can properly mimic and regulate the tissue microenvironment’s physical, mechanical, chemical, and biological properties, manage adherence of biomolecules and adjust the material’s degradability. The present review article is focused on synthetic materials used in craniofacial tissue engineering in recent decades. Copyright © 2022 Yazdanian, Alam, Abbasi, Rahbar, Farjood, Tahmasebi, Tebyaniyan, Ranjbar and Hesam Arefi.
Barzegar, Peyman Esmaeili Fard,
Ranjbar R.,
Yazdanian, A.R.,
Tahmasebi, Elahe,
Alam, Mostafa Publication Date: 2022
Materials Today Communications (23524928)
Periodontal disease is a persistent condition that damages tooth-related structures and causes tooth loss. It can be seen as gingivitis or periodontitis. Approximately 80% of adults suffer from gingivitis worldwide. Bacteria are essential for the development of this destructive disease. Although many of these bacteria are normal oral microflora, some risk factors help them produce biofilm, which causes inflammation in the oral cavity. Numerous therapeutic approaches are used to treat periodontal disease, minimize its symptoms, and possibly restore lost tissues, including behavioral-change techniques, systemic and local chemical drugs (chlorhexidine, zinc oxide, and silver-containing materials), and different kinds of surgeries. Natural materials comprise various chemical structures that have several biological activities. Therefore, they are at the center of attention in this decade. Herbal medicines have been used to manage periodontal disease, owing to their general safety and efficacy. Some of these studies are performed on volunteer patients, and some of them on laboratory animals. In this review, the results of in vitro, in vivo, and clinical trial studies (Recent decade) of chemical and herbal medicinal materials were collected to treat periodontal diseases to help future studies. © 2022 Elsevier Ltd
Seyyed Hajizadeh, Yasamin,
Harzandi, Naser,
Babapour, Ebrahim,
Yazdanian, A.R.,
Ranjbar R. Publication Date: 2022
Advances In Materials Science And Engineering (16878434)
The propolis produced by bees is used by them to protect their hives. The cavity inside the hive's walls is filled in during cold days to reduce entry points and mummify any intruders to ensure their survival. A current focus in nanotechnology and nanoscience is the green biosynthesis of nanoparticles (NPs) using biomaterials. Research on green methods for making metal oxide NPs is gaining momentum to safeguard the environment from the potential dangers associated with toxic chemicals. This study aimed to synthesize copper NPs (CuNPs) via propolis extraction, a novel application of nanoscience. The study was conducted under a range of pH, time conditions, and concentration ratios, and its properties were characterized by UV-Vis absorption spectra, XRD, and FTIR. An FTIR analysis revealed that compounds found in propolis extract could have an effect on the surface modification of the synthesized NPs. The propolis (Khalkhal) extract spectrum exhibited a sharp peak at 3422 cm-1, caused by free hydroxyl groups and their intra/intermolecular hydrogen bonds. There were sharp peaks at 2925, 1637, and 1515 to 1076 cm-1 associated with the C = O and C = C aromatic stretching frequencies. According to UV-Vis spectrophotometry investigation, CuO NPs exhibit a characteristic peak at 385 nm, showing significant surface plasmon resonance (SPR) with propolis (Khalkhal) extract. Furthermore, specific wavelengths of CuO NPs demonstrate peaks at 243, 292, and 350 nm for propolis (Gilan) extract. The green synthesis of CuNPs from Gilan and Khalkhal propolis can be an appropriate candidate for clinical applications such as drug delivery systems, drug formulation, and biomedical applications. © 2022 Yasamin Seyyed Hajizadeh et al.
Yazdanian, A.R.,
Alam, Mostafa,
Rafiee, Esmail,
Tahmasebi, Elahe,
Ghaffarpasand, Arash Publication Date: 2022
Dentistry 3000 (21678677)(1)
Objectives: Root canal treatment (RCT) has high technical sensitivity, and many human procedural errors can compromise the success of treatment and well-being of patients. The failure modes and effects analysis (FMEA) is a risk assessment and management tool that ensures the safety of patient care by a systematic approach to failures. This study aimed to identify the potential errors and failures in the process of RCT using the FMEA. Methods: This descriptive study evaluated the failure modes and their effects qualitatively and quantitatively using the FMEA methodology. For this purpose, a FMEA team was first established and the steps of RCT were described in a flowchart. Next, the potential errors and failures in each step were identified, and each failure mode was scored from 1 to 10, based on the severity of impact, likelihood of occurrence, and likelihood of detection. The three scores were multiplied to obtain the risk priority number (RPN). Corrective measures and preventive strategies were suggested for high-risk failure modes (RPN≥250). Results: The FMEA identified 19 steps and 48 potential failures in the process of RCT. The maximum RPN in the process of RCT was assigned to file fracture in the root canal (RPN=324), apical extrusion of irrigating solution (RPN=320), and inappropriate or no rubber dam isolation (RPN=315). Conclusion: The FMEA has high efficacy for detection and prioritization of improvable points in a complex dental procedure in a busy department such as the endodontics department. Copyright: ©2022 Yazdanian M, et al.
Tahmasebi, Elahe,
Karami, Shahryar,
Hajisadeghi, Samira,
Tavallaie, Mahmood,
Yazdanian, A.R. Publication Date: 2022
Journal of Mazandaran University of Medical Sciences (17359279)(212)
Background and purpose: Dental and skeletal features, unlike soft tissues, remain unchanged in events where most body tissues are destroyed such as car accidents, plane crash, crimes, etc. Panoramic and lateral cephalometric radiographs can provide useful information about dental and cephalometric indicators in human identification. Materials and methods: A cohort retrospective study was carried out in five stages, including collecting the samples, using a specific tooth counting system, identifying the landmarks in panoramic radiographs and designing a dental formula, designing anatomical formula with cephalometric indicators and identifying operator errors, and matching and data analysis. Results: We studied 180 people, including 97 (54%) women and 83 men aged 15-59 (mean age= 25.5) years in Tehran. Average indexes of missing (M), filled (F), Root Canal Therapy (RCT) teeth, crown (C), (Body/Go-Go), (Mf-Mf/Mf-Go(R+L)), De, P, ER, Go in lateral Cephalometry, SNA, SNB, Basal, N-Ans-Me, Ans-Pns/Go-Me, and S-Go/N-Me were not significantly different between cases by comparing the graphs before and after treatments (P>0.05). Examination of average indices of implant and dilacerated teeth in general and without considering the number of teeth, did not show a significant difference when the pre/post-treatment graphs were compared (P>0.05). In examining the Co-Ans/Co-Gn, Go in panoramic graph, (S-N/S-Ba) and S-N-Ba, no significant difference was observed between the cases (P>0.05). Conclusion: Panoramic, lateral cephalometric graphs and designing creative formula can be used in human identification. © 2022, Mazandaran University of Medical Sciences. All rights reserved.
Yazdanian, A.R.,
Karami, Shahryar,
Tahmasebi, Elahe,
Alam, Mostafa,
Abbasi, Kamyar Publication Date: 2022
Scanning (01610457)
The heavy casualties associated with mass disasters necessitate substantial resources to be managed. The unexpectedly violent nature of such occurrences usually remains a problematic amount of victims that urgently require to be identified by a reliable and economical method. Conventional identification methods are inefficient in many cases such as plane crashes and fire accidents that have damaged the macrobiometric features such as fingerprints or faces. An appropriate recognition method for such cases should use features more resistant to destruction. Forensic dentistry provides the most appropriate available method for the successful identification of victims using careful techniques and precise data interpretation. Since bones and teeth are the most persistent parts of the demolished bodies in sudden mass disasters, scanning and radiographs are unrepeatable parts of forensic dentistry. Forensic dentistry as a scientific method of human remain identification has been considerably referred to be efficient in disasters. Forensic dentistry can be used for either "sex and age estimation,""Medical biotechnology techniques,"or "identification with dental records,"etc. The present review is aimed at discussing the development and implementation of forensic dentistry methods for human identification. For this object, the literature from the last decade has been searched for the innovations in forensic dentistry for human identification based on the PubMed database. © 2022 Mohsen Yazdanian et al.
Yazdanian, A.R.,
Rostamzadeh, Pouya,
Rahbar, Mahdi,
Alam, Mostafa,
Abbasi, Kamyar Publication Date: 2022
Bioinorganic Chemistry and Applications (15653633)
Orodental problems have long been managed using herbal medicine. The development of nanoparticle formulations with herbal medicine has now become a breakthrough in dentistry because the synthesis of biogenic metal nanoparticles (MNPs) using plant extracts can address the drawbacks of herbal treatments. Green production of MNPs such as Ag, Au, and Fe nanoparticles enhanced by plant extracts has been proven to be beneficial in managing numerous orodental disorders, even outperforming traditional materials. Nanostructures are utilized in dental advances and diagnostics. Oral disease prevention medicines, prostheses, and tooth implantation all employ nanoparticles. Nanomaterials can also deliver oral fluid or pharmaceuticals, treating oral cancers and providing a high level of oral healthcare. These are also found in toothpaste, mouthwash, and other dental care products. However, there is a lack of understanding about the safety of nanomaterials, necessitating additional study. Many problems, including medication resistance, might be addressed using nanoparticles produced by green synthesis. This study reviews the green synthesis of MNPs applied in dentistry in recent studies (2010-2021). © 2022 Mohsen Yazdanian et al.
Tahmasebi, Elahe,
Hakim, Lotfollah Kamali,
Yazdanian, A.R.,
Asadi, Amirali,
Garajei, Ata Publication Date: 2022
Cellular and Molecular Biology (01455680)(12)
This is the eighth most malignant tumor in the world, causing the highest incidence and malignancy rate of all cancers in the mouth and maxillofacial region. In cells, miRNAs regulate development, differentiation, proliferation, and differentiation, and miRNA expression is a better indicator of physiological status than DNA expression. miR-21, miR-132, miR-29a, miR-204, and miR-138 levels were measured in plasma from patients with primary OSCC and healthy controls. A Real Time-PCR technique was used to measure miR-21, miR-132, miR-29a, miR-29a, and miR-204 expression levels in plasma from 38 healthy and 38 people with primary OSCC. A standard distribution test and a CT unit were used to confirm the quantitative data on miRNA expression. Gene expression levels were compared between two groups of patients and healthy groups using a Mann-Whitney test and an unpaired t-test. MiR-21's median CT value was 29.68 in the OSCC group and 32.89 in the healthy group, and miR-29a's median CT value was 37.54 and 36.46 in the OSCC group and healthy group, respectively. Additionally, miR-132's CT values were 37.71 and 36.40, miR-138's CT value was 35.37 and 31.21, and miR-204's CT value was 36.44 and 36.17. The results showed that miR-21 expression levels increased significantly, while miR-29a, miR-132, and miR-138 (P < 0.05), and miR-204 expression levels did not differ significantly (P > 0.05). As a result of this study, the expression levels of microRNAs may be considered to diagnose OSCC at an early stage. It is essential to diagnose this disease early to improve treatment and patient health outcomes. Copyright: © 2022 by the C.M.B. Association. All rights reserved.
Yazdanian, A.R.,
Motallaei, Mohammad Nima,
Tahmasebi, Elahe,
Tebyaniyan, Hamid,
Alam, Mostafa Publication Date: 2022
BioMed Research International (23146133)
Multimicrobial infections caused by pathobionts are called dysbiotic multimicrobial illnesses. Commercial mouthwashes, such as chlorhexidine, have negative side effects that can prevent tooth decay and infection. The present study aimed to determine the antifungal, antibacterial, and cytotoxicity characteristics of the propolis extracts from different areas (Iran). The ethanolic extract of propolis was prepared. GC/MS carried out the characterization to determine the thymol, carvacrol, and menthol extracts, and also, total phenol and flavonoid were assed for all samples. The antimicrobial and antibiofilm effects were evaluated against S. mutans, S. mitis, S. salivarius, L. acidophilus, E. coli, S. aureus, and C. albicans. The cytotoxic effect of extracts was measured on human fibroblast cells by MTT test. The MIC values in mg mL-1 were ranged as follows: S. salivarius (0.003 to 0.048), S. mutans (0.003 to 0.029), S. mitis (0.007 to 0.058), L. acidophilus (0.007 to 0.117), C. albicans (0.014 to 0.234), E. coli (0.007 to 0.058), and S. aureus (0.007 to 0.058), while MBC were, respectively, S. mutans (0.007 to 0.058), S. salivarius (0.007 to 0.117), S. mitis (0.007 to 0.117), L. acidophilus (0.014 to 0.234), C. albicans (0.029 to 0.468), E. coli (0.014 to 0.234), and S. aureus (0.007 to 0.117). Cariogenic bacteria and Candida albicans were demonstrated to be resistant to propolis extracts. Therefore, propolis extracts may make good mouthwashes. © 2022 Mohsen Yazdanian et al.
Publication Date: 2021
BMC Medical Education (14726920)(1)
Background: Tooth decay and periodontitis are among the most prevalent dental diseases globally with adverse effects on an individual’s general health. Recently the prevalence of dental caries has decreased significantly, but caries epidemiology remains a major problem in dental public health. This study investigated the impact of an oral health education intervention on Theory of Planned Behavior (TPB) variables, and whether changes in these variables persisted and were associated with changes in identified oral health behaviors at 2-month follow-up. Methods: This descriptive pre/post test study was conducted with 160 staff in the Baqiyatallah Hospital in Tehran. Six hospital wards were selected using a randomized multi-stratified sampling frame. The size for each cluster was calculated as 22 with each ward being allocated to either the intervention or the control arm of the study. Self-report questionnaires were used to evaluate socio-demographic factors, dental attendance as well as the constructs of the augmented TPB model (attitudes, subjective norms, perceived behavioral control intentions). The intervention was an educational program based on TPB constructs delivered via direct training to half the participants. The control group was provided with usual training only. The independent-samples T-test, Repeated-Measures one-way ANOVA, and matched T-test with the significance level set at p < 0.05 were applied. Results: Findings revealed significant variations between the two groups immediately after the educational intervention concerning the attitudes, subjective norms, perceived behavioral control, intentions to seek treatment, oral health behavior as well as decayed, missing, and filled teeth and bleeding on probing (p<0.001). Two months after the intervention, except for the brushing construct (p = 0.18), the differences between the two groups were all statistically significant (p<0.001). Conclusion: Our findings affirm the positive effect an oral health education program has on enhancing the attitudes, subjective norms, perceived behavioral control, intentions and behavior of staff in this hospital. The results of our study confirm that developing and applying an educational intervention in accordance with the theory of planned behavior can lead to significant changes in the knowledge, attitudes, and behavior of hospital staff regarding preventing tooth decay. © 2021, The Author(s).
Yazdanian, A.R.,
Arefi, Arian Hesam,
Alam, Mostafa,
Abbasi, Kamyar,
Tebyaniyan, Hamid Publication Date: 2021
Journal of Materials Research and Technology (22387854)
Dental problems including cavities, periodontitis, apical periodontitis, and pulpitis are among the most cost-consuming burden for both patients and the health care system all over the world. The pathological consequences of these complications importantly lead to tooth loss causing functional and psychological conflictions for patients. The traditional treatment includes removing the impaired tooth or its restoration using hard restorative materials that are supposed to mimic the tissue of enamel or dentine whereas these materials cannot simulate the chemical, biological, or physical characteristics of a natural tooth. Therefore, different daily-progressing methods of tissue engineering (TE) are being propounded as new and promising approaches for managing dentistry conflicts. TE is now considered almost a practical, reproducible, and clinically safe therapy for regenerating different oral and dental tissues including either the whole dental organ or its various anatomical parts. TE necessarily constitutes three angles of stem cell (SC), scaffold, and essential growth factors (GFs). Generally, scaffolds can be made of decellularized scaffolds (usually containing the extra-cellular matrix (ECM) of target organs and tissues) or biologic scaffolds (containing natural polymer). The current study aims to review the studies conducted in the recent decade on decellularized and biological scaffolds and their potential applications in modern regenerative dentistry. © 2021 The Author(s)
Tafazoli Moghadam, Ehsan,
Yazdanian, A.R.,
Alam, Mostafa,
Tebyaniyan, Hamid,
Tafazoli, Ali Publication Date: 2021
Journal of Materials Research and Technology (22387854)
Tissue regeneration is a vital phenomenon in the skeletal system of human beings during their life span. The structure of bony architecture and teeth are highly dependent to this ongoing procedure to maintain their functional form. Regarding the fundamental function of our skeletal system, all the involved components are at constant risk for injuries and deformations throughout the life. Therefore, in modern medicine, promotion of bone and tooth regeneration has become a critical counter measure to correct these acquired defects. There are numerous ways to address the bone and tooth related erosive pathologies but utilization of natural compounds has gained immense popularity in recent years. These materials provide a broad spectrum of therapeutic agents with a variety of biological characteristics. In this review, a comprehensive exploration has been implemented to extract and categorize the relevant scientific evidence on this issue, based on the source of natural candidates and the potential clinical indications. Database searching presented a considerable data pool with more than 300 references in this field. According to the results, all the proposed items can be categorized in two major groups including scaffolding and osteogenesis (or dentinogenesis) induction. The clinical applicability of a number of them is properly demonstrated in clinical trials but for the rest, more examinations are required to reach a conclusive decision. © 2021 The Author(s)
Soudi, Armin,
Yazdanian, A.R.,
Ranjbar R.,
Tebyaniyan, Hamid,
Yazdanian, Alireza Publication Date: 2021
EXCLI Journal (16112156)
Recently, a growing attention has been observed toward potential advantages of stem cell (SC)-based therapies in regenerative treatments. Mesenchymal stem/stromal cells (MSCs) are now considered excellent candidates for tissue replacement therapies and tissue engineering. Autologous MSCs importantly contribute to the state-of-the-art clinical strategies for SC-based alveolar bone regeneration. The donor cells and immune cells play a prominent role in determining the clinical success of MSCs therapy. In line with the promising future that stem cell therapy has shown for tissue engineering applications, dental stem cells have also attracted the attention of the relevant researchers in recent years. The current literature review aims to survey the variety and extension of SC-applica-tion in tissue-regenerative dentistry. In this regard, the relevant English written literature was searched using key-words: “tissue engineering”, “stem cells”, “dental stem cells”, and “dentistry strategies”. According to the available database, SCs application has become increasingly widespread because of its accessibility, plasticity, and high proliferative ability. Among the growing recognized niches and tissues containing higher SCs, dental tissues are evidenced to be rich sources of MSCs. According to the literature, dental SCs are mostly present in the dental pulp, periodontal ligament, and dental follicle tissues. In this regard, the present review has described the recent findings on the potential of dental stem cells to be used in tissue regeneration. © 2021, Leibniz Research Centre for Working Environment and Human Factors. All rights reserved.
Publication Date: 2021
Biointerface Research in Applied Chemistry (20695837)(1)
Acute promyelocytic leukemia is the most prevalent AML malignancy. The side effects caused by chemotherapeutic drugs have primarily led to the increased use of natural products for cancer treatment. Gaillardin, a medicinal herb, has been reported to have anti-proliferative effects on various cancer cells. In this study, cytotoxic and apoptotic effects of Gaillardin were investigated on acute promyelocytic leukemia cell lines, NB4. Different concentrations of Gaillardin were used to treat NB4 cells for 48 and 72 hours. Then cell viability was assessed using MTT assay. Flow cytometry was applied to the assessment of apoptosis by using Annexin V and Propidium iodide staining method. In order to determine the expression levels of Bax and Bcl-2, RT-PCR was carried out. Statistical data analysis was done by ANOVA (one-way). MTT assay results showed that Gaillardin concentrations of 7, 8, and 9 µM would significantly reduce the percentage of live cells (P< 0.001)c. Flow cytometry results showed that Gaillardin significantly increased apoptotic cell percentage in comparison with the control groups (p< 0.05). Gaillardin can be considered as a candidate for further studies on the methods for treating various cancer types. © AMG Transcend Association. All rights reserved.
Tahmasebi, Elahe,
Yazdanian, A.R.,
Rafiei, Esmail,
Yaraghi, Navid,
Karamali, Mazyar Publication Date: 2021
Journal of Military Medicine (17351537)(4)
Background and Aim: Evidence-Based Dentistry (EBD) is an approach to preserve the oral health through proper integration of scientific evidence and oral and medical conditions of the patient, clinical skills of the dentist, and the priorities of the patient. This research was conducted to study the Evaluation of Evidence-Based Dental Care (EBD) that was performed at Shahid Shokri Dental Center. Methods: This study was an applied research and a descriptive-analytical one which was done by the cross-sectional method in 2019. The statistical populations were consisted of all dentists working in Shahid Shokri Dental Center and selected by simple sampling method. Data collection was done through library study and field observation by a researcher-made questionnaire and EBD tool. Data analysis was performed using Spss software, statistical analysis methods and Pearson correlation test. Results: The mean score of dentists' knowledge about EBD was 34.27 ± 0.685; attitude score was 32.73 ± 0.641 and clinical evidence resource access score was 33.57 ± 0.638. There was a significant relationship between the level of knowledge of dentists and their field of study and history. There was a significant relationship between attitude level with age and field of study. In the area of dentists 'access to clinical evidence sources, there was a significant relationship between access level with age and field of study. Dentists' use of guides in selected sections had a medium to high spectrum, which was evaluated as good by dentists in prosthetics. Clinical guides (guidelines) for the ward, endo, orthodontic and restoration ward were updated. Conclusion: The status of EBD care at Shahid Shokri Dental Center and the details of this skill were assessed based on its average components. There was no negative attitude, but there was a need to strengthen, hospitalize and create the right conditions for EBD dentists. It is recommended to conduct comprehensive training courses, discourse building, system design, and EBD-based assessment mechanisms and update the guidelines at Shahid Shokri Dental Center. © 2021 Baqiyatallah University of Medical Sciences. All rights reserved.
