Publication Date: 2025
ACS Symposium Series (19475918)1497pp. 89-140
Using biomaterial engineering, bioactive molecules can be integrated with scaffolds to develop materials aimed at treating damaged tissues and organs. To mitigate the adverse impacts of scientific research on materials and methods, green chemistry employs safe and environmentally friendly techniques. A significant goal of green technology is to minimize the harmful effects of toxic substances on both humans and the environment. Despite its benefits, green chemistry has drawbacks such as dependence on raw materials, limited awareness of the chemicals used, and high costs associated with material preparation. We provide an in-depth review of the synthesis techniques and structural properties of biomaterials crucial to advancements in tissue engineering. Beginning with an overview of the foundational principles in biomaterial science, the chapter explores the critical role of scaffolds in facilitating tissue regeneration, including bone, skin, and cartilage. A key focus is on sustainable synthesis methods, particularly those aligned with green chemistry, which employ renewable sources such as agricultural and animal by-products. We present a comparative evaluation of both natural polymers, like chitosan and collagen, and synthetic alternatives such as polycaprolactone (PCL), emphasizing their respective strengths in biocompatibility, biodegradability, and mechanical properties. The effectiveness of in situ and ex vivo tissue engineering strategies is reviewed, and their potential to replicate the complex architecture of native tissues and drive functional recovery is assessed. Key challenges and limitations of current biomaterial scaffolds are also addressed. Emerging technologies, such as 3D printing, nanotechnology, and bio-sensing innovations, are discussed in relation to their capacity to overcome existing barriers and improve scaffold design. The chapter concludes by advocating for the optimization of synthesis methods and the integration of smart materials to enhance scaffold performance, setting the groundwork for future breakthroughs in regenerative medicine. © 2025 American Chemical Society.
Hosseini, S.,
Landrani, A.,
Moghadam, M.,
Sun, Y.,
Tangestaninejad, S.,
Mirkhani, V.,
Mohammadpoor-baltok, I.,
Karimi-maleh, H.,
Mozaffari, M. Publication Date: 2025
Energy and Fuels (08870624)39(24)pp. 11782-11792
Plasma catalysis for CO2 utilization technology shows considerable promise for advancement, with enhancing the synergistic relationship between plasma and catalysts being a key area of research challenge. However, current research focuses on the design of efficient catalyst formulations, but studies on metal-organic framework (MOF) screening and cold plasma methods have received less attention. Therefore, in this study, the hydrogenation of CO2 at ambient temperature and pressure was investigated using single-metal and bimetallic ZIF-67 as a MOF catalyst with the assistance of a dielectric barrier discharge (DBD) plasma reactor. The Co ZIF-67 and Ni Co ZIF-67 were synthesized and characterized by different analytical techniques. The synergistic effects between DBD plasma and these mono- and bimetal MOFs were investigated for the transformation protocol of CO2 to methanol. The flow rate of gas and input voltage as main parameters were screened. In this procedure, monometallic and bimetallic ZIF-67 showed 69.6 and 90.3% conversion with 84.1 and 98.1% selectivity of CH3OH production and 2.7 and 4.8 (mmol/kJ) energy efficiency under optimized conditions (flow rate: 60 mL/min; input voltage: 10 kV). Besides, the specific input energy of the transformation as a kinetic parameter was measured and showed linear behavior. The two catalysts can be reused up to six times without significant loss of their catalytic activities. © 2025 American Chemical Society.
Rahimi, M.,
Landrani, A.,
Moghadam, M.,
Safari, R.,
Hadi, H.,
Mohammadpoor baltork, I.,
Tangestaninejad, S.,
Nasiri, N.,
Kia, R. Publication Date: 2025
Scientific Reports (20452322)15(1)
Molecular wires represent a cornerstone of next-generation nanoelectronics, yet the design of highly efficient, short molecular conductors remains a significant challenge. In this study, we present a catalyst-free, green synthetic route for the preparation of anilino-1,4-naphthoquinone enaminone derivatives via aqueous-phase Michael addition between anilines and 1,2-naphthoquinone-4-sulfonic acid sodium salt. The reaction proceeds rapidly at room temperature, yielding products with excellent efficiency (96–98%) and exceptional purity, as confirmed by comprehensive spectroscopic characterization (FT-IR, UV-Vis, 1H and 13C NMR, MS) and elemental analysis. Single-crystal X-ray diffraction further validated the molecular structures of representative compounds. Theoretical investigations using Density Functional Theory (DFT) and Quantum Theory of Atoms in Molecules (QTAIM) provided deep insights into the electronic properties and charge transport behavior of these systems. Key analyses included cohesive energy calculations, UV-Vis exciton energy profiles, frontier molecular orbital energies (HOMO/LUMO), chemical reactivity descriptors (hardness, softness, chemical potential), and dipole moment variations under external electric fields (0-140 × 10− 4 a.u.). Additionally, localized orbital locator (LOL) contours, electron density Laplacians, and current-voltage (I–V) characteristics based on Landauer theory were evaluated to assess charge transport efficiency. Comparative analysis reveals that extending the π-conjugation in a molecular system markedly improves its electronic properties, leading to lower energy gaps, enhanced conductance, and greater field responsiveness, which are critical for molecular wire functionality. Furthermore, this work combines sustainable synthesis with advanced computational modeling to offer a robust framework for the design and evaluation of short molecular wires for nanoelectronic devices. © The Author(s) 2025.
Landrani, A.,
Mohammadpoor baltork, I.,
Moghadam, M.,
Mirkhani, V.,
Tangestaninejad, S.,
Safari, R.,
Hadi, H. Publication Date: 2024
Scientific Reports (20452322)14(1)
In this work, we demonstrate that palladium-immobilized triazine dendrimer on magnetic nanoparticles in proper solvents, provides an impressive, atom-economical and compelling approach for the selective synthesis of 2,3-diphenylindole or pentaphenylpyrrole derivatives via annulation of diphenylacetylene with diverse anilines. Both the annulation methods were taken place under copper- and phosphine-free conditions with high yields at air atmosphere. Likewise, bis-indoles were obtained with excellent yields under optimized reaction conditions. Besides, the catalyst was isolated and reused for seven cycles without decrease potential of catalytic activity. Two mechanistic pathways were proposed and geometry optimizations, electronic properties as well as vibrational characterizations of all structures were performed with density functional theory (DFT). Also, the investigation of atomic basin properties of these molecular systems was carried out utilizing the quantum atoms-in-molecules theory (QTAIM). The results showed that 2,3-diphenylindole and pentaphenyl pyrrole molecular systems can be used as intramolecular acceptor/donor (n-like/p-like) sections. © The Author(s) 2024.
Landrani, A.,
Arabi, M.,
Rezaei, S.,
Moghadam, M.,
Tangestaninejad, S.,
Mohammadpoor baltork, I.,
Mirkhani, V.,
Mokhtariyan, M. Publication Date: 2024
ACS Applied Bio Materials (25766422)7(7)pp. 4406-4416
In this research, we utilized an efficient approach to synthesize superparamagnetic graphene oxide (SPGO) rapidly in a one-pot method using microwave irradiation of graphene oxide (GO), urea, and Fe(III) ion. Tannic acid (TA) was introduced to the surface of SPGO through a straightforward and eco-friendly process. Methods were devised to furnish GO nanosheets and modify their surfaces with TA in an environmentally friendly manner. Two series of nanosheets, namely, SPGO/TA-COOH and SPGO/TA-IM, were engineered on the surface and used for immobilizing lipase enzyme. Through various analytical tools, the unique biocatalysts SPGO/TA-COOH/L and SPGO/TA-IM/L were confirmed. These biocatalysts exhibited enhanced stability at high temperatures and pH levels compared with free lipase. They also demonstrated prolonged storage stability and reusability over four months and seven cycles, respectively. Furthermore, the catalytic activity of immobilized lipase showed minimal impairment based on kinetic behavior analysis. The kinetic constants of SPGO/TA-IM/L were determined as Vmax = 0.24 mM min-1, Km = 0.224 mM, and kcat = 0.8 s-1. Additionally, the efficiency of biocatalysts for biodiesel production from palmitic acid was studied, focusing on various reaction parameters, such as temperature, alcohol to palmitic acid molar ratio, water content, and lipase quantity. The esterification reaction of palmitic acid with methanol, ethanol, and isopropanol was tested in the presence of SPGO/TA-COOH/L and SPGO/TA-IM/L, and the corresponding esters were obtained with a yield of 30.6-91.6%. © 2024 American Chemical Society.
Publication Date: 2023
ChemistrySelect (23656549)8(9)
This work synthesized a novel colorimetric ligand based on the compound quinazolinone (Sensor) and investigated it. The sensing activity of the sensor toward different cation was studied. The sensor demonstrated a highly selective colorimetric sensing toward Hg2+ with a detection limit of 0.1 ppb and visual color change from colorless to Purple in methanol-water solvents (v/v, 10,90). The cation binding character was determined using visual inspection, UV-Vis, and fluorescence analyses. In the computational part, the interaction between the receptor and Hg2+ ion was investigated using density functional theory (TD-DFT) and quantum theory of atoms in molecules (QTAIM) in the solution phase (in the presence of water as solvent and the CPCM model). Theoretical studies have shown that electronic properties such as energy gap, absorption energy, charge/energy transfer, and optical properties change dramatically in the presence of Hg2+ cations. Also, the effect of the electric field on the electronic properties of the sensor/Hg2+ complex improved the Hg2+ cation adsorption process.
Aghamolaei, M.,
Landrani, A.,
Bahadori, M.,
Nori, Z.Z.,
Rezaei, S.,
Moghadam, M.,
Tangestaninejad, S.,
Mirkhani, V.,
Mohammadpoor baltork, I. Publication Date: 2022
RSC Advances (20462069)12(10)pp. 5971-5977
The self-assembly approach was used for amine decoration of core/shell Fe3O4@Au with 4- aminothiophenol. This structure was used for covalent immobilization of lipase using a Ugi 4- component reaction. The amine group on the structure and carboxylic group from lipase can react in the Ugi reaction and a firm and stable covalent bond is created between enzyme and support. The synthesized structure was fully characterized and its activity was explored in different situations. The results showed the pH and temperature stability of immobilized lipase compared to free lipase in a wide range of pH and temperature. Also after 60 days, it showed excellent activity while residual activity for the free enzyme was only 10%. The synthesized structure was conveniently separated using an external magnetic field and reused 6 times without losing the activity of the immobilized enzyme. © 2022 The Author(s).
Asgari, V.,
Landrani, A.,
Salehi, H.,
Amirpour, N.,
Hashemibeni, B.,
Kazemi, M.,
Bahramian, H. Publication Date: 2020
Journal of Molecular Neuroscience (08958696)70(11)pp. 1836-1850
Gold nanoparticles (AuNPs) have been proposed as useful medical carriers in the field of regenerative medicine. This study aimed to assess the direct conjugation ability of retinoic acid (RA) with AuNPs and to develop a strategy to differentiate the human adipose-derived stromal/stem cells (hADSCs) into neurons using AuNPs-RA. The physical properties of this nanocarrier were characterized using FT-IR, TEM, and FE-SEM. Moreover, the efficiency of RA conjugation on AuNPs was determined at 99% using UV-Vis spectroscopy. According to the MTT assay, an RA concentration of 66 μM caused a 50% inhibition of cell viability and AuNPs were not cytotoxic in concentrations below 5 μg/ml. Real-time PCR and immunocytochemistry proved that AuNPs-RA is able to increase the expression of neuronal marker genes and the number of neuronal protein (GFAP and MAP2)-positive cells, 14 days post-induction of hADSCs. Taken together, these results confirmed that the AuNPs-RA promote the neuronal differentiation of hADSCs. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
Rezaei, S.,
Landrani, A.,
Moghadam, M.,
Tangestaninejad, S.,
Mirkhani, V.,
Mohammadpoor baltork, I. Publication Date: 2020
ACS Applied Bio Materials (25766422)3(12)pp. 8414-8426
To expand the field of nanomaterial and engineering of enzyme in eco-friendly processes, gold mesoflower (Au-MF) nanostructure was applied for preparation of three series of immobilized lipase (Au-MF/SAM 1-3) through biofunctionalization of surface by Ugi multicomponent reaction. The synthesized Au-MF/SAM 1-3/lipase as unique biocatalysts was confirmed by different analytical tools and techniques. Compared to the free lipase, the Au-MF/SAM 1-3/lipase showed more stability at high temperature and pH. Also, these biocatalysts showed high storage stability and reusability after 2 months and eight cycles, respectively. Moreover, the kinetic behavior was investigated and the results showed a minimal impairment of catalytic activity of immobilized lipase. The kinetic constants of the immobilized lipase, Au-MF/SAM 2/lipase, are Km = 0.37 mM, Vmax = 0.22 mM min-1, and kcat = 154 min-1. The immobilized lipase showed smaller activation energy (Ea) than that of free enzyme, indicating that the immobilized enzyme is less sensitive to temperature. In the following, the biodiesel production from palmitic acid was studied in the presence of Au-MF/SAM 2/lipase as an efficient biocatalyst. The influence of different reaction parameters such as temperature, molar ratio of alcohol to palmitic acid, water content, and lipase amount was deeply investigated. ©
Landrani, A.,
Mohammadpoor baltork, I.,
Mirkhani, V.,
Moghadam, M.,
Tangestaninejad, S.,
Amiri rudbari, H. Publication Date: 2020
RSC Advances (20462069)10(36)pp. 21198-21205
Dendrimers are of great interest due to their special structural topology and chemical versatility. Owing to their properties, dendrimers have found practical applications in catalytic processes as efficient nanoreactors. Therefore, we herein report an environmentally attractive strategy and highly efficient route for the synthesis of a wide variety of diaryl sulfides using palladium nanoparticles immobilized on a nano-silica triazine dendritic polymer (Pdnp-nSTDP) as a nanoreactor. In this manner, different diaryl or aryl heteroaryl sulfides and bis(aryl/heteroarylthio)benzene/anthracene/pyridine derivatives were preparedviaC-S cross-coupling reactions of aryl halides with diaryl/diheteroaryl disulfides under thermal conditions and microwave irradiation. The catalyst could be easily recovered and reused several times without any significant loss of its activity. © The Royal Society of Chemistry 2020.
Nori, Z.Z.,
Landrani, A.,
Bahadori, M.,
Moghadam, M.,
Mirkhani, V.,
Tangestaninejad, S.,
Mohammadpoor baltork, I. Publication Date: 2020
RSC Advances (20462069)10(55)pp. 33137-33147
A novel and unique platform was prepared based on a dendrimer containing thiol groups supported on nanosilica (nSTDP), and ultrafine platinum nanoparticles were synthesized and immobilized on the thiol decorated branches of nSTPD. The new catalyst, (Ptnp@nSTDP), was characterized by different techniques such as FE-SEM, TEM, ICP, XPS and DR UV-vis. This heterogeneous catalyst presented an outstanding performance for the synthesis of benzimidazole and benzothiazole derivatives through a reaction between benzyl alcohol derivatives and 2-aminothiophenol or 1,2-phenylenediamine. No requirement for the pre-reduction of catalysts and using water as a green solvent make it an individual catalyst for these reactions. Furthermore, the catalyst can be easily recovered and reused five consecutive times in the production of benzimidazoles and benzothiazoles without significant leaching of Pt and loss of its activity which illustrated the chemical stability of the catalyst during the reaction. © 2020 The Royal Society of Chemistry.
Rezaei, S.,
Landrani, A.,
Moghadam, M.,
Tangestaninejad, S.,
Mirkhani, V.,
Mohammadpoor baltork, I. Publication Date: 2019
Chemical Engineering Journal (13858947)356pp. 423-435
The natural cascade processes lead to inspire researchers to bring diverse biocatalysts together in an artificial way. In this work, we are going to introduce a brilliant double enzyme microsystem prepared from co–immobilization of glucose oxidase (GOD) and glucoamylase (GA) on silver dendrites hierarchical (Ag–DH) nanostructure through Ugi four-component reaction (Ugi–4CR) in water, as the green solvent at ambient temperature. The success preparation of the unique biocatalyst system was confirmed by FT–IR, UV–Vis, TGA, XRD, TEM, FE–SEM, AFM and elemental analysis. The properties of free and immobilized enzymes were investigated and compared. The immobilized GA and GOD had higher Km (Michaelis constant) and lower Vmax (maximum reaction velocity) than their native forms. The values of activation energy (Ea) for both the immobilized enzymes were smaller than those with native enzymes, implying that the immobilized enzymes are more temperature insensitive. The obtained double enzyme microsystem was employed as a biocatalyst for one pot transformation of starch to gluconic acid as an exclusive cascade reaction under mild conditions and in aqueous medium, and the final product obtained in high yield. Moreover, the artificial biomimetic microsystem exhibited high stability and reusability after eight cycles. These results demonstrated the feasibility of this approach for co-immobilization of enzyme on hierarchical structures may be extended to other biocatalytic cascades, thereby opening a new window for the other artificial biotransformations in chemistry. © 2018 Elsevier B.V.
Asgari, V.,
Landrani, A.,
Salehi, H.,
Amirpour, N.,
Hashemibeni, B.,
Rezaei, S.,
Bahramian, H. Publication Date: 2019
Neurochemical Research (03643190)44(12)pp. 2695-2707
Stem cells have been long looked at as possible therapeutic vehicles in regenerative medicine largely due to their multi-lineage differentiation potential and paracrine actions. Therefore, development of new procedures for the differentiation of stem cells into different cell types holds great potential for opening new opportunities in regenerative medicine. In addition to various methods for inducing stem cell differentiation, the utilization of nanomaterials for differentiation of stem cells has recently received considerable attention and has become a potential tool for such purpose. Multiple lines of evidence revealed that nanomaterial-based scaffolds, inorganic nanoparticles (NPs), and biodegradable polymers have led to significant progress in regulation of stem cell differentiation. Several studies indicated that different NPs including selenium, gold, graphene quantum dots (QDs) and silica could be employed for the regulation of differentiation of stem cells such as human mesenchymal stem cells (hMSCs). In addition, magnetic core–shell NPs could be applied for the regulation of neural stem cell (NSC) differentiation. Taken together, these findings suggested that NPs are potential candidates which could be utilized for the differentiation of stem cells into various cell types such as neural cells. Herein, we summarized the application of NPs for differentiation of stem cells into various cells in particular neural cells. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
Haghshenas kashani, S.,
Landrani, A.,
Moghadam, M.,
Tangestaninejad, S.,
Mirkhani, V.,
Mohammadpoor baltork, I. Publication Date: 2018
Applied Organometallic Chemistry (02682605)32(9)
In this paper, we present the synthesis of Au nanoparticles supported on nanosilica thiol based dendrimer, nSTDP. The catalyst was prepared by reduction of HAuCl4 with NaBH4 in the presence of nSTDP. The resulting Aunp–nSTDP materials were characterized by FT–IR and UV–vis spectroscopic methods, SEM, TEM, TGA, XPS and ICP analyses. The characterization of the catalyst showed that Au nanoparticles with the size of 2–6 nm are homogeneously distributed on the nSTDP dendrimer with a catalyst loading of about 0.19 mmol/g of catalyst. The Aunp–nSTDP catalyst was used in the oxidation of alcohols with tert–butyl hydroperoxide (TBHP) as oxidant. The influence of vital reaction parameters such as solvent, oxidant and amount of catalyst on the oxidation of alcohols was investigated. These reactions were best performed in an acetonitrile/water mixture (3:2) in the presence of 0.76 mol% of the catalyst on the basis of the Au content at 80 °C under atmospheric pressure of air to afford the desired products in high yields (80–93% for benzyl alcohols). The Aunp–nSTDP catalyst exhibited a high selectivity toward the corresponding aldehyde and ketone (up to 100%). Reusabiliy and stability tests demonstrated that the Aunp–nSTDP catalyst can be recycled with a negligible loss of its activity. Also this catalytic exhibited a good chemoselectivity in the oxidation of alcohols. © 2018 John Wiley & Sons, Ltd.
Asadi, B.,
Landrani, A.,
Mohammadpoor baltork, I.,
Tangestaninejad, S.,
Moghadam, M.,
Mirkhani, V.,
Amiri rudbari, H. Publication Date: 2017
ACS Combinatorial Science (21568952)19(6)pp. 356-364
Unsymmetrical 1,2,5,6-tetrahydropyridine-3-carboxylates were obtained for the first time from a five-component Fe3O4@TDSN-Bi(III)-catalyzed reaction of aryl aldehydes, aryl amines, and ethyl acetoacetate. This magnetically separable catalyst enabled the selective incorporation of two different aryl amines or two different aryl aldehydes into the product, and provided excellent yields, short reaction times, mild reaction conditions, satisfactory catalyst recyclability, and low catalyst loading. © 2017 American Chemical Society.
Landrani, A.,
Moghadam, M.,
Mohammadi, S.,
Royvaran, M.,
Moshtael-arani, N.,
Rezaei, S.,
Tangestaninejad, S.,
Mirkhani, V.,
Mohammadpoor baltork, I. Publication Date: 2017
Langmuir (15205827)33(34)pp. 8503-8515
Owing to properties of magnetic nanoparticles and elegant three-dimensional macromolecule architectural features, dendrimeric structures have been investigated as nanoscale drug delivery systems. In this work, a novel magnetic nanocarrier, generation two (G2) triazine dendrimer modified Fe3O4@SiO2 magnetic nanoparticles (MNP-G2), was designed, fabricated, and characterized by Fourier transform infrared (FT-IR), thermal gravimetric analysis (TGA), vibrating sample magnetometer (VSM), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), and dynamic light scattering (DLS). The prepared MNP-G2 nanosystem offers a new formulation that combines the unique properties of MNPs and triazine dendrimer as a biocompatible material for biomedical applications. To demonstrate the potential of MNP-G2, the nanoparticles were loaded with methotrexate (MTX), a proven chemotherapy drug. The MTX-loaded MNP-G2 (MNP-G2/MTX) exhibited a high drug-loading capacity of MTX and the excellent ability for controlled drug release. The cytotoxicity of MNP-G2/MTX using an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide based assay and MCF-7, HeLa, and Caov-4 cell lines revealed that MNP-G2/MTX was more active against the tumor cells than the free drug in a mildly acidic environment. The results of hemolysis, hemagglutination, and coagulation assays confirmed the good blood safety of MNP-G2/MTX. Moreover, the cell uptake and intracellular distribution of MNP-G2/MTX were studied by flow cytometry analysis and confocal laser scanning microscopy (CLSM). This research suggests that MNP-G2/MTX with good biocompatibility and degradability can be selected as an ideal and effective drug carrier in targeted biomedicine studies especially anticancer applications. © 2017 American Chemical Society.
Asadi, B.,
Landrani, A.,
Mohammadpoor baltork, I.,
Tangestaninejad, S.,
Moghadam, M.,
Mirkhani, V.,
Amiri rudbari, H. Publication Date: 2017
Tetrahedron Letters (00404039)58(1)pp. 71-74
Fe3O4-TDSN-Bi(III) was utilized as an efficient and reusable catalyst for the regioselective one-pot synthesis of quinoline derivatives from arylamines, arylaldehydes and methyl propiolate under microwave irradiation and solvent-free conditions. Also, bis-quinolines were obtained in high yields from dialdehydes or diamines. Atom-economy, high to excellent yields, easy work-up, as well as simple catalyst recovery and reusability are the key features of this procedure. © 2016 Elsevier Ltd
Nazari, R.,
Aghababaie, M.,
Razmjou, A.,
Landrani, A.,
Amini, M.,
Hajjari, M.,
Mirkhani, V.,
Moghadam, M.,
Taheri kafrani, A. Publication Date: 2017
Desalination and Water Treatment (19443994)64pp. 81-89
Forward osmosis (FO) has gained attention recently due to its low cost and energy consumption while it happens naturally. However, finding a proper draw agent for this process is a challenging task. Magnetic nanoparticles, especially with modified surfaces, have been reported as a promising draw agent, which can be easily recovered by using a magnetic field. Here, an attempt was made to study the effect of different superparamagnetic iron oxide nanoparticles (SPIONs) surface engineering on the osmotic pressure, hydrophilicity, degree of agglomeration of nanoparticles and also water flux. In this study, the osmotic potential of naked Fe3O4, silica-coated superparamagnetic iron oxide nanoparticles (SPION@SiO2), hyperbranched polyglycerol/carboxylate-functionalized SPION (SPION@SiO2@ HPG and SPION@SiO2@HPG-CO2H) were evaluated for FO process. The effect of ionized SPIONs on the water flux has been studied for the first time, too. The SPIONs were characterized by scanning electron microscopy, transmission electron microscopy, X-ray powder diffraction, Fourier transform infrared, vibrating sample magnetometer and thermogravimetric analysis. The average of water flux in a long-term performance of FO for the introduced draw agents increased in the order of SPION < SPION@SiO2 < SPION@SiO2@HPG < SPION@SiO2@HPG-CO2H due to higher hydrophilicity and lesser agglomerations and precipitation. It was surprisingly observed that water flux of ionic magnetic draw solution behaves differently comparing with the non-ionic ones. It was revealed that ionic SPIONs at high concentration led to the formation of non-ideal polyelectrolyte solution that produces a high osmotic pressure. However, by the permeation of water, a transition from non-ideal to ideal solution at some point was observed during FO process. © 2017 Desalination Publications. All rights reserved.
Shirani, E.,
Razmjou, A.,
Tavassoli, H.,
Landrani, A.,
Rezaei, S.,
Abbasi kajani, A.,
Asadnia, M.,
Hou, J.,
Ebrahimi warkiani, M. Publication Date: 2017
Langmuir (15205827)33(22)pp. 5565-5576
This study is an attempt to make a step forward to implement the very immature concept of pumpless transportation of liquid into a real miniaturized device or lab-on-chip (LOC) on a plastic substrate. "Inert" plastic materials such as polypropylene (PP) are used in a variety of biomedical applications but their surface engineering is very challenging. Here, it was demonstrated that with a facile innovative wettability patterning route using fluorosilanized UV-independent TiO2 nanoparticle coating it is possible to create wedge-shaped open microfluidic tracks on inert solid surfaces for low-cost biomedical devices (lab-on-plastic). For the future miniaturization and integration of the tracks into a device, a variety of characterization techniques were used to not only systematically study the surface patterning chemistry and topography but also to have a clear knowledge of its biological interactions and performance. The effect of such surface architecture on the biological performance was studied in terms of static/dynamic protein (bovine serum albumin) adsorption, bacterial (Staphylococcus aureus and Staphylococcus epidermidis) adhesion, cell viability (using HeLa and MCF-7 cancer cell lines as well as noncancerous human fibroblast cells), and cell patterning (Murine embryonic fibroblasts). Strategies are discussed for incorporating such a confined track into a diagnostic device in which its sensing portion is based on protein, microorganism, or cells. Finally, for the proof-of-principle of biosensing application, the well-known high-affinity molecular couple of BSA-antiBSA as a biological model was employed. © 2017 American Chemical Society.
Tavassoli, M.,
Landrani, A.,
Moghadam, M.,
Tangestaninejad, S.,
Mirkhani, V.,
Mohammadpoor baltork, I. Publication Date: 2016
ACS Sustainable Chemistry and Engineering (21680485)4(3)pp. 1454-1462
Silica-nanoparticle-supported copper-containing ionic liquid (SNIL-Cu(II)) provided a highly stable, active, reusable, spherical, and solid-phase catalyst for click chemistry. The SNIL-Cu(II) catalyst was readily prepared from 1,2-bis(4-pyridylthio)ethane immobilized on silica nanoparticles modified with 3-chloropropyltrimethoxysilane and Cu(OTf)2, and the morphology, structure, and properties of nanoparticles were investigated through different analytical tools. This catalytic system showed high activity in a one-pot synthesis of 1,4-disubstituted 1,2,3-triazoles by click reactions between a variety of alkynes, organic halides, and sodium azide at room temperature in aqueous polyethylene glycol as a green medium with a high turnover frequency (up to 7920 h-1). Moreover, the SNIL-Cu(II) was also used as an efficient catalyst for the preparation of a series of multifold 1,4-disubstituted 1,2,3-triazoles. Also, this unique catalyst was readily reused without any decrease in its catalytic activity to give the corresponding triazoles quantitatively. © 2015 American Chemical Society.
Publication Date: 2016
Chemical Engineering Journal (13858947)288pp. 414-422
Immobilized enzymes are used as biocatalysts for analytical purposes in diagnostics and for preparative purposes in large scale industrial processes. Immobilization can increase the half-life, improve the stability, and increase the catalytic activity of an enzyme. It facilitates the separation and recovery of the catalyst from the reaction products, and allows for multiple use of the biocatalysts. Graphene oxide nanosheets were decorated with superparamagnetic iron oxide nanoparticles (SPGO) and functionalized with cyanuric chloride (SPGO-CC) to serve as solid support for the covalent immobilization of enzymes. Xylanase was attached to the functionalized nanocomposite with a yield of 215 mg protein pergram SPGO-CC. The kinetic constants of the immobilized (of the free soluble) xylanase are Km=4.9 (4.1) mg/mL, vmax=1.6 (1.7)μmol min-1 mL-1, and kcat=82 (91) min-1, indicating a minimal impairment of catalytic activity by covalent coupling. The immobilized xylanase has shallow pH and temperature optima of 6.5 and 60°C. It retains 70% of the original activity after 10 cycles of 15min incubation with substrate (polymeric xylan) at 60°C. It retains 80% of the original catalytic activity after 3.5months storage at 4°C, whereas the free, soluble enzyme retains only 50%. © 2015 Elsevier B.V.
Publication Date: 2016
Journal of Biomedical Materials Research - Part A (15493296)104(9)pp. 2220-2233
Bacterial adhesion and subsequent biofilm formation on metals such as aluminum (Al) alloys lead to serious issues in biomedical and industrial fields from both an economical and health perspective. Here, we showed that a careful manipulation of Al surface characteristics via a facile two-steps superhydrophobic modification can provide not only biocompatibility and an ability to control protein adsorption and bacterial adhesion, but also address the issue of apparent long-term toxicity of Al-alloys. To find out the roles of surface characteristics, surface modification and protein adsorption on microbial adhesion and biofilm formation, the surfaces were systematically characterized by SEM, EDX, XPS, AFM, FTIR, water contact angle (WCA) goniometry, surface free energy (SFE) measurement, MTT, Bradford, Lowry and microtiter plate assays and also flow-cytometry and potentiostat analyses. Results showed that WCA and SFE changed from 70° to 163° and 36.3 to 0.13 mN m−1, respectively. The stable and durable modification led to a substantial reduction in static/dynamic BSA adsorption. The effect of such a treatment on the biofilm formation was analyzed by using three different bacteria of Pseudomonas aeruginosa, Staphylococcus epidermidis, and Staphylococcus aureus. The microtiter plate assay and flow cytometry analysis showed that the modification not only could substantially reduce the bacterial adhesion but this biofouling resistance is independent of bacterium type. An excellent cell viability after exposure of HeLa cells to waters incubated with the modified samples was observed. Finally, the corrosion rate reduced sharply from 856.6 to 0.119 MPY after superhydrophobic modifications, which is an excellent stable corrosion inhibition property. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2220–2233, 2016. © 2016 Wiley Periodicals, Inc.
Rezaei, S.,
Landrani, A.,
Moghadam, M.,
Tangestaninejad, S.,
Mirkhani, V.,
Mohammadpoor baltork, I. Publication Date: 2016
RSC Advances (20462069)6(95)pp. 92463-92472
The organic palladium complex (trans-dichlorobis(4-iodoaniline-κN)palladium(ii)) was encapsulated into a porous metal-organic framework MIL-Cr (Pd complex@MIL-Cr) using ship-in-a-bottle strategy. The novel catalyst as a three dimensional nanoreactor was fully characterized using different techniques such as XRD, BET, XPS, SEM, EDX, TEM and ICP. The Pd complex@MIL-Cr is isostructural to the parent MIL-Cr framework, with a high surface area and pore volume of ca. 1418 m2 g-1 and 0.87 cm3 g-1, respectively. The nanoreactor was highly efficient in the catalytic conversion of aryl halides, showing extraordinarily higher activity than the homogeneous Pd counterparts. Surprisingly, high yields were achieved in Suzuki-Miyaura and Heck coupling reactions of chloroarenes bearing a wide range of substituents. Besides, this protocol could be extended to the cross-couplings of 2-bromo and 2,6-dibromopyridine with arylboronic acids in excellent yields at room temperature. The Pd complex@MIL-Cr was also used as an efficient and convenient catalyst for the preparation of a series of C3-symmetric molecules with benzene, pyridine or pyrimidine units as the central core. Moreover, the catalyst could be recovered easily and reused several times without any considerable loss of its catalytic activity. Investigation of the nature of the recovered catalyst showed that the catalyst is converted to Pd nanoparticles. © 2016 The Royal Society of Chemistry.
Asadi, B.,
Mohammadpoor baltork, I.,
Tangestaninejad, S.,
Moghadam, M.,
Mirkhani, V.,
Landrani, A. Publication Date: 2016
New Journal of Chemistry (11440546)40(7)pp. 6171-6184
A new Bi(iii) immobilized triazine dendrimer-stabilized magnetic nanoparticle (Fe3O4@TDSN-Bi(iii)) catalyst was prepared and characterized by FT-IR, TGA, elemental analysis, FE-SEM, TEM, VSM, XRD, XPS and lCP-OES techniques. This catalyst was used efficiently for the preparation of different aminonaphthoquinones via a one-pot three-component reaction of lawsone, aldehydes and amines in EtOH as a green solvent at room temperature. This catalytic system also showed excellent activity in the synthesis of symmetric and unsymmetric bis-aminonaphthoquinones from dialdehyde and/or diamine in high yields and purity via an easy work-up procedure. The easy recovery and reusability of the catalyst make this method attractive for green chemistry. This journal is © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2016.
Publication Date: 2015
Chemical Engineering Journal (13858947)270pp. 235-243
The covalent binding of xylanase to silica-coated modified magnetite nanoparticles via cyanuric chloride activation was investigated. The structure, size, and magnetic properties of the support and immobilized xylanase were characterized by transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), Fourier-transform infrared spectra (FTIR), thermo-gravimetric analysis (TGA) and vibrating sample magnetometer (VSM) analysis. The TEM images showed that the xylanase immobilized on functionalized magnetic nanoparticles (xylanase-MNPs) possessed three dimensional core-shell structures with an average diameter of ~9nm. The FTIR and XPS results demonstrated the successful immobilization of xylanase on functionalized MNPs. Results from Bradford protein assay and TGA indicated that xylanase was covalently attached to the surface of modified magnetic nanoparticles with immobilization yield of 280mg enzyme/gMNPs. The VSM analysis revealed that Fe3O4, Fe3O4@SiO2 and xylanase-MNPs had high saturation magnetization of 69.4, 63.84 and 46.56emu/g, respectively. Enzymatic activity, reusability, thermo-stability, pH-stability, and storage stability of the immobilized xylanase were found significantly superior to those of the free one. The xylanase-MNPs exhibited maximal catalytic activity at pH 6.5 and 60°C and the immobilized enzymes were found to keep as high as 80% of the activity of free ones. Notably, xylanase-MNPs showed quite impressive stability, even after 9 reaction cycles, it could still retain about 65% of the initial activity. The measurement of Michaelis-Menten parameters (Km and vmax) also revealed the considerable improvement of immobilized enzyme. The results suggested that xylanase-MNPs could be used in an interesting range of application allowing both using in broader temperature and pH ranges, facilitating long-term storage, while permitting magnetic recovery of the enzyme for reuse or purification of the product. © 2015 Elsevier B.V.
Tavassoli, M.,
Landrani, A.,
Moghadam, M.,
Tangestaninejad, S.,
Mirkhani, V.,
Mohammadpoor baltork, I. Publication Date: 2015
Applied Catalysis A: General (0926860X)503pp. 186-195
Copper(II) complex of 1,2-bis(4-pyridylthio)ethane immobilized on polystyrene was a used as a highly stable, active, reusable and green catalyst for click synthesis of 1,2,3-triazoles via one-pot three-component reaction of organic halides, sodium azide and alkynes. The catalyst was characterized by FT-IR spectroscopy, thermogravimetric analysis, elemental analysis, field emission scanning electron microscopy, energy dispersive X-ray, transmission electron microscopy and elemental analysis. High selectivity, broad diversity of organic halides or α-bromoketones and alkyl/aryl terminal alkynes, and excellent yields of the products were obtained using 0.2 mol% of catalyst. This catalytic system also showed excellent activity in the synthesis of bis-1,4-disubsitituted 1,2,3-triazoles. Moreover, the catalyst could be recycled and reused for seven cycles without any decrease in its catalytic activity.
Landrani, A.,
Taheri kafrani, A.,
Amini, M.,
Mirkhani, V.,
Moghadam, M.,
Soozanipour, A.,
Razmjou, A. Publication Date: 2015
Langmuir (15205827)31(33)pp. 9219-9227
Although several strategies are now available for immobilization of enzymes to magnetic nanoparticles for bioapplications, little progresses have been reported on the use of dendritic or hyperbranched polymers for the same purpose. Herein, we demonstrated synthesis of magnetic nanoparticles supported hyperbranched polyglycerol (MNP/HPG) and a derivative conjugated with citric acid (MNP/HPG-CA) as unique and convenient nanoplatforms for immobilization of enzymes. Then, an important industrial enzyme, xylanase, was immobilized on the nanocarriers to produce robust biocatalysts. A variety of analytical tools were used to study the morphological, structural, and chemical properties of the biocatalysts. Additionally, the results of biocatalyst systems exhibited the substantial improvement of reactivity, reusability, and stability of xylanase due to this strategy, which might confer them a wider range of applications. © 2015 American Chemical Society.
Anvar, S.,
Mohammadpoor baltork, I.,
Tangestaninejad, S.,
Moghadam, M.,
Mirkhani, V.,
Khosropour, A.R.,
Landrani, A.,
Kia, R. Publication Date: 2014
ACS Combinatorial Science (21568952)16(3)pp. 93-100
The synthesis of a variety of 2,3-disubstituted quinolines has been achieved successfully via a one-pot three-component reaction of arylamines, arylaldehydes and aliphatic aldehydes in the presence of butylpyridinium tetrachloroindate(III), [bpy][InCl4], ionic liquid as a green catalyst and solvent. Mild conditions with excellent conversions, and simple product isolation procedure are noteworthy advantages of this method. The recyclability of the ionic liquid makes this protocol environmentally benign. © 2014 American Chemical Society.
Landrani, A.,
Mohammadpoor baltork, I.,
Mirkhani, V.,
Moghadam, M.,
Khosropour, A.R.,
Tangestaninejad, S.,
Nasr-esfahani, M.,
Amiri rudbari, H. Publication Date: 2014
Synlett (09365214)25(5)pp. 645-652
A wide variety of diaryl sulfides has been synthesized in excellent yields via C-S cross-couplings of aryl/heteroaryl halides with aromatic/heteroaromatic thiols in the presence of palladium nanoparticles immobilized on nanosilica triazine dendritic polymer (Pd np -nSTDP) as a reusable catalyst under thermal conditions and microwave irradiation. Pd np -nSTDP also showed excellent catalytic activity for the preparation of a series of di- and trisulfides with benzene, pyridine, pyrimidine, and/or 1,3,5-triazine as the central cores by one-pot multi C-S cross-coupling reactions.© Georg Thieme Verlag Stuttgart. New York.
Landrani, A.,
Mohammadpoor baltork, I.,
Mirkhani, V.,
Khosropour, A.R.,
Moghadam, M.,
Tangestaninejad, S. Publication Date: 2014
European Journal of Organic Chemistry (10990690)2014(25)pp. 5603-5609
Palladium nanoparticles immobilized on nano-silica triazine dendritic polymer (Pdnp-nSTDP) was found to be a highly effective catalyst for the Sonogashira cross-coupling of aryl halides (iodides, bromides, and chlorides) with aromatic and aliphatic terminal alkynes. This reaction was best performed in water as a green solvent in the presence of just 0.01 mol-% of the catalyst at room temperature. Efficient synthesis of V- and star-shaped polyalkynylated molecules with a benzene, pyridine, or pyrimidine central core was also achieved through Sonogashira cross-coupling of dihalo and trihalo aromatics with terminal alkynes in the presence of this catalytic system. The Pdnp-nSTDP catalyst was easily recovered and reused several times without significant loss of reactivity. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Landrani, A.,
Mohammadpoor baltork, I.,
Mirkhani, V.,
Khosropour, A.R.,
Moghadam, M.,
Tangestaninejad, S.,
Kia, R. Publication Date: 2013
Advanced Synthesis and Catalysis (16154169)355(5)pp. 957-972
A new catalyst based on palladium nanoparticles immobilized on nano-silica triazine dendritic polymer (Pdnp-nSTDP) was synthesized and characterized by FT-IR spectroscopy, thermogravimetric analysis, field emission scanning electron microscopy, energy dispersive X-ray, transmission electron microscopy and elemental analysis. The size of the palladium nanoparticles was determined to be 3.1±0.5 nm. This catalytic system showed high activity in the Suzuki-Miyaura cross-coupling of aryl iodides, bromides and chlorides with arylboronic acids and also in the Heck reaction of these aryl halides with styrenes. These reactions were best performed in a dimethylformamide (DMF)/water mixture (1:3) in the presence of only 0.006 mol% and 0.01 mol% of the catalyst, respectively, under conventional conditions and microwave irradiation to afford the desired coupling products in high yields. The Pdnp-nSTDP was also used as an efficient catalyst for the preparation of a series of star- and banana-shaped compounds with a benzene, pyridine, pyrimidine or 1,3,5-triazine unit as the central core. Moreover, the catalyst could be recovered easily and reused several times without any considerable loss of its catalytic activity. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
