Articles
Journal of Applied Psychological Research (22518126)15(1)pp. 1-18
Aim: The aim of the present study was to investigate the Effectiveness of Dweck’s Mindset intervention on negative orientation towards problem and hopelessness in high school students. Method: The present study is an applied type and the project’s plan was a quasi-experimental study(pretest-posttest) and a control group. The statistical population consisted high school students (female) in Isfahan who were selected using multi-stage random sampling method. Negative Orientation Towards Problem questionnaire(NPOQ) and The Beck Hopelessness Scale(BHS) were research tools. 183 students completed the questionnaires. In the first screening step, 50 students were selected by purposive sampling. 30 students were randomly placed in the second step into experimental(n=15) and control groups(n=15). The experimental group received 8 sessions. Data were analyzed using MANCOVA by SPSS-23. Findings: There was a significant difference between experimental and control groups in the negative orientation towards problem(P<0.01) and Dweck’s Mind Set reduced that. But in the hopelessness Scale, it has only been effective on the dimensions of despair in achieving desires and negative expectations of the future. Conclusion: Based on the results the motivational Dweck’s MindSet intervention has been affected on diminish negative orientation to the problem, negative expectations of the future and hope in achieving the desires.
Journal of Applied Psychological Research (22518126)16(1)pp. 15-26
The objective of the current investigation was to investigate the perceptions of wisdom held by Iranian gifted school instructors. In order to accomplish this objective, a descriptive phenomenological methodology was implemented. The statistical population of the research consisted of teachers from gifted schools in Isfahan in 2022. Purposive sampling was implemented to identify participants, and data acquisition was maintained until saturation was achieved. The study involved 21 teachers, with interviews lasting between 30 and 45 minutes. Eight of the instructors were male and thirteen were female. Interviews were conducted in-depth to facilitate a two-way dialogical exchange and obtain a comprehensive understanding of the teachers’ perspectives. The data derived from the interviews were analyzed using Clark and Brown's six-step model. Additionally, Lincoln and Guba’s four criteria were implemented to guarantee the credibility and validity of the investigation. The results indicated that the conceptualization of wisdom by gifted school teachers is characterized by three primary themes: cognitive and rational skills, communication and interpersonal skills, and compassion and concern for others. The results of this study suggest that teachers’ perceptions reflect certain aspects of wisdom, while others, as emphasized in the literature, are underemphasized. © The Author(s).
Pouyan A.,
Ghorbanlo M.,
Eslami M.,
Jahanshahi M.,
Ziaei E.,
Salami A.,
Mokhtari K.,
Shahpasand K.,
Farahani N.,
Meybodi T.E.,
Entezari M.,
Taheriazam A.,
Hushmandi K.,
Hashemi M.,
Mohseni, A.,
Mohseni, A.,
Mohseni, A.,
Nourizadeh, S.S.,
Mohseni, A.,
Serri, F.,
Abedi, A.,
Abedi, A.,
Boroujeni, A.J.,
Faramarzi, S.,
Faramarzi, S.,
Vashaee, D.,
Hesabi, A.,
Karami, S.,
Karami, S.,
Karami, S.,
Karami, S. Molecular Cancer (14764598)(1)pp. 89-100
Glioblastoma multiforme (GBM) is the most prevalent and aggressive primary brain tumor in adults, characterized by a poor prognosis and significant resistance to existing treatments. Despite progress in therapeutic strategies, the median overall survival remains approximately 15 months. A hallmark of GBM is its intricate molecular profile, driven by disruptions in multiple signaling pathways, including PI3K/AKT/mTOR, Wnt, NF-κB, and TGF-β, critical to tumor growth, invasion, and treatment resistance. This review examines the epidemiology, molecular mechanisms, and therapeutic prospects of targeting these pathways in GBM, highlighting recent insights into pathway interactions and discovering new therapeutic targets to improve patient outcomes. © The Author(s) 2025.
Soostani S.B.,
Ranjbar M.,
Memarian, A.,
Mohammadi M.,
Yaghini Z.,
Hassanzadeh, F.,
Akrami, L.,
Akrami, L.,
Hassanzadeh, F.,
Akrami, L.,
Behzadnezhad, N.,
Rahmati adarmanabadi e., ,
Jafari e., E.,
Malekpour, M.,
Malekpour, M.,
Jafari e., E.,
Malekpour, M.,
Marandi, S.M.,
Nourmohammadi abadchi, A.,
Zarei, S.,
Faramarzi, S.,
Zarei, S.,
Faramarzi, S.,
Feiz m.h., M.H.,
Abedi, A.,
Sadeghi-aliabadi, H.,
Abedi, A.,
Lanki, M.,
Bardia, F. BMC Plant Biology (14712229)(1)pp. 228-237
Chitosan, a non-toxic and biodegradable compound, enhances plant growth and secondary metabolite production, presenting innovative approaches to mitigating plant stress. Salinity, a common abiotic stress, significantly impairs plant growth and development. This study investigates the effects of chitosan on the physiological, biochemical, and gene expression responses of salt-stressed Brassica napus L. exposed to NaCl concentrations of 0, 50, 100, and 150 mM. Chitosan was applied as a foliar spray at concentrations of 0, 5 and 10 mg/L. The research focuses on gene expression changes in P5CS, PIP, and PAL genes in the roots and shoots of Brassica napus, revealing notable alterations, particularly in PIP expression under saline conditions. The study also observed enhanced PAL enzyme activity, increased chlorophyll and proline levels, and changes in iron, potassium, and nitrogen content. These findings demonstrate chitosan’s potential to improve plant resilience to salt stress. By modulating gene expression and enhancing physiological responses, chitosan presents a promising solution for enhancing plant tolerance to salinity, with valuable implications for agricultural practices. © The Author(s) 2025.
