Articles
Nevi G.,
Basile G.,
Kaufmann H.R.,
Fotouhi Ardakani M.,
Hesabi, A. Kybernetes (0368492X)pp. 149-173
Purpose: In the context of triple-bottom-line dynamics, societal components grapple with multifaceted challenges, necessitating changing behaviours within business-to-business (B2B) processes. This study investigates how collaborative relations in B2B ecosystems can influence social, environmental and economic sustainability dynamics, exploring whether the former two positively impact economic results. Design/methodology/approach: Validating a conceptual framework via partial least squares (PLS) structural equation modelling, a quantitative study on 262 Iranian SME stakeholders was conducted. Findings: The research underscores the paramount role of B2B relations, emphasizing the shift towards interconnected relations between society, institutions, end-users and businesses. The findings suggest that B2B collaborative efforts within a broader ecosystem address social and environmental needs, thereby contributing to transforming the ecosystem’s business models. Innovatively, the research elicited that environmental and social effects have a positive mediating effect on economic results. Originality/value: By proposing a business-social-institutional model (B2SI) grounded in relational and dynamic capabilities, this study contributes to advancing both scientific understanding and business practices, pointing to the important role of social responsibility within B2B ecosystems. © 2024, Emerald Publishing Limited.
Pouyan A.,
Ghorbanlo M.,
Eslami M.,
Jahanshahi M.,
Ziaei E.,
Salami A.,
Mokhtari K.,
Shahpasand K.,
Farahani N.,
Meybodi T.E.,
Entezari M.,
Taheriazam A.,
Hushmandi K.,
Hashemi M.,
Mohseni, A.,
Mohseni, A.,
Mohseni, A.,
Nourizadeh, S.S.,
Mohseni, A.,
Serri, F.,
Abedi A.,
Abedi A.,
Boroujeni, A.J.,
Faramarzi S.,
Faramarzi S.,
Vashaee, D.,
Hesabi, A.,
Karami, S.,
Karami, S.,
Karami, S.,
Karami, S. Molecular Cancer (14764598)(1)pp. 89-100
Glioblastoma multiforme (GBM) is the most prevalent and aggressive primary brain tumor in adults, characterized by a poor prognosis and significant resistance to existing treatments. Despite progress in therapeutic strategies, the median overall survival remains approximately 15 months. A hallmark of GBM is its intricate molecular profile, driven by disruptions in multiple signaling pathways, including PI3K/AKT/mTOR, Wnt, NF-κB, and TGF-β, critical to tumor growth, invasion, and treatment resistance. This review examines the epidemiology, molecular mechanisms, and therapeutic prospects of targeting these pathways in GBM, highlighting recent insights into pathway interactions and discovering new therapeutic targets to improve patient outcomes. © The Author(s) 2025.
International Journal of Multilingualism (14790718)
Accessibility to healthcare information is contingent upon effective health communication, particularly for individuals with poor English ability. Communication is hampered by language problems, which can lead to miscommunication and restricted access to healthcare. While machine translation (MT) presents a potential solution, its effectiveness in healthcare remains understudied. This study assesses the linguistic comprehensibility of health-related translations using both MT and human translation (HT), aiming to identify challenges and opportunities for enhancing health communication. The study utilised mixed methods, combining qualitative thematic analysis with quantitative poll questionnaires. Health-related translations from the ‘Health Translations’ website were categorised and assessed for linguistic comprehensibility using comprehensibility using the Patient-oriented and Culturally-adapted (POCA) model's six categories. MT generally outperformed HT in generating high-quality translations, especially in technical or specialised terminology and abstract concepts. However, HT excelled in categories requiring nuanced language and context comprehension. Specific linguistic challenges identified included abstract translations, coherence issues, and complex sentence structures, hindering comprehension among non-native speakers. Despite challenges, MT showed significant progress in improving linguistic comprehensibility, particularly in health-related contexts. This study provides insights into MT and HT effectiveness in health communication. In healthcare settings, using precise language is essential to improving comprehension and minimising misinterpretation. © 2025 Informa UK Limited, trading as Taylor & Francis Group.
Language Related Research (23223081)16(1)pp. 115-137
The representation of future pre-configuration through policy-making processes has been an in-vogue area of study in the field of discourse analysis. Equally important is the reconstruction of future pre-configuration in the institutional translations of political text and talk. The objective of this study is to investigate the conceptualization of futurity in the preemptive policy-making in the speeches of the Iranian Supreme Leader and their English institutional translations. The data for the present study comes from 20 speeches of the Iranian Supreme Leader and their translations, spanning from 2015-2020, issued by the Office of the Supreme Leader. We employed semantic-syntactic analytical tools such as mood, modality, and aspect to study the conceptualization of futurity in the policy discourse. In conclusion, the findings of the study indicate that these reconstruction of futurity in the preemptive policy-making process in the English institutional translations are to a greater extent similar to the semantic-syntactic properties of the original texts. However, modalization and mood transformation are instances of differences between original and translated versions of texts. Besides, we argued that any instance of the occurrence of similarity or differences stems from on-line dialectic relationships between micro-pragmatic and macro-pragmatic factors. © 2025, Tarbiat Modares University. All rights reserved.
Kazeminasab F.,
Mahboobi M.H.,
Mohebinejad M.,
Nojoumi M.,
Belyani S.,
Camera, D.M.,
Moradi S.,
Bagheri, R.,
Yalsharzeh, R.,
Barati, H.,
Hesabi, A. Current Developments in Nutrition (24752991)(4)pp. 108-122
Background: The growing prevalence of obesity and related chronic diseases has led to increased interest in interventions targeting ectopic fat reduction to which its accumulation is linked to metabolic dysfunction. Objectives: This study aimed to evaluate the effects of combined exercise training combined with dietary interventions compared with dietary interventions alone on ectopic fat [visceral fat area (VFA), liver fat, intramuscular fat (IMF), pancreatic fat, renal sinus fat, and pericardial and epicardial fats] in adults with overweight and obesity, both with and without chronic diseases. Methods: Web of Science, Scopus, and PubMed were searched for original articles up to 1 March, 2024, that included exercise compared with control interventions on body weight and ectopic fat in adults with overweight or obesity. Weighted mean differences (WMD) for body weight, liver fat, pancreatic fat, and renal sinus fat and standardized mean differences (SMD) for VFA, IMF, pericardial and epicardial fats, and 95% confidence intervals were determined using random-effects models. Results: Thirty-two studies, including 1488 participants and 38 intervention groups, met the inclusion criteria. The combined intervention of exercise and diet did not reduce body weight (WMD = –0.23 kg, P = 0.180), liver fat (WMD = 0.05%, P = 0.730), IMF (SMD = –0.08, P = 0.640), pericardial and epicardial fats (SMD = –0.12, P = 0.280), pancreatic fat (WMD = –0.24%, P = 0.370), and renal sinus fat (WMD = 0.01 cm2, P = 0.170) when compared with a diet-only group. Interestingly, exercise combined with diet significantly reduced VFA in participants with obesity (SMD = –0.12, P = 0.040) and healthy males (SMD = –0.33, P = 0.001) when compared with a diet-only group. Conclusions: The findings suggest that combined exercise and dietary interventions did not lead to significant reductions in most ectopic fat depots when compared with diet alone. However, a modest reduction in VFA was observed in participants with obesity and healthy males. These results highlight the nuanced impact of exercise in combination with dietary interventions and the need to consider specific fat depots and participant characteristics in obesity management strategies. The trial was registered at PROSPERO as CRD42024546770. © 2025 The Author(s)
