Publication Date: 2005
Journal of the Royal Asiatic Society (14740591)15(3)pp. 261-277
Amiridavan, M.,
Nemati, S.,
Hashemi, S.M.,
Jamshidi m., M.,
Saberi, A.,
Asadi, M. Publication Date: 2006
Journal Of Research In Medical Sciences (17357136)11(4)pp. 263-269
Background: Sudden sensorineural hearing loss (SSNHL) is a perplexing condition for patients and there are many controversies about its etiology, audiologic characteristics, prognostic factors, and treatment. Methods: In this prospective study, we performed some audiologic tests, including PTA, IA, ABR, and OAE (TEOAE) before beginning treatment of 53 patients with SSNHL. We assigned the patients randomly to two treatment groups: oral steroids + acyclovir vs. intravenous urographin. Twenty-eight patients underwent Magnetic Resonance Imaging (MRI) of the Brain. Results: Of 53 patients (22 female and 31 male), 22 (41.5%) had negative or no signal to noise ratio and overall correlation in TEOAE. Twenty-six patients (49%) had positive overall correlations less than 50%, and 5 patients (4.4%) had overall correlations >50%. Fifteen patients (28.3%) responded completely or well, 20 (37.7%) responded partially, and 18 (33.9%) had poor or no response to the treatment. The mean values for overall correlation in 3 subgroups of patients (no response, partial response, and complete response) were - 3.5% (± 1/16%), +11% (± 1/ 99%), and +36.6% (± 3/07%), respectively (P = 0.01). Twenty out of 52 patients had no reproducible wave in ABR (38.5%), and waves I, III, and V were absent in 40 (77%), 31 (59.6%) and 21 (40%) patients, respectively. There were some limitations (false positive and false negative results) in ABR use in our cases, but it may be useful in detecting site of lesion in SSNHL. Overall, according to the results of OAE, ABR, and brain MRI of these patients, 3 were affected by acoustic neurinomas, at least 1 had auditory neuropathy, and the site of lesion was cochlear in 6, and cochlear + retrocochlear in 13 patients. Conclusions: ABR has limitations for use in SSNHL and seems not to obviate the need for brain MRI, but may help in determining the site of lesions such as ischemia or neuropathy. Overall correlation (and S/N ratio) in TEOAE is a valuable prognostic factor in SSNHL, hence we recommend performing TEOAE in every patient with SSNHL.
Publication Date: 2006
Journal of the Royal Asiatic Society (14740591)16(1)pp. 29-41
Publication Date: 2006
Journal of the Royal Asiatic Society (14740591)16(2)pp. 151-163
Salek, M.,
Hashemipour, M.,
Hashemi, S.M.,
Hajrahimi, M.,
Sadeghi, S.,
Farajzadegan, Z.,
Hovsepian, S.,
Hadian, R. Publication Date: 2007
Journal of Isfahan Medical School (10277595)25(87)pp. 53-59
Background: Congenital hypothyroidism (CH) has a considerably high prevalence in our country, and without early treatment, it would lead to irreversible sequelae like hearing impairment. This study was aimed to investigate the prevalence of hearing loss in children with CH in comparison with healthy children. Methods: This case-control study was conducted in two groups of children; the case group consisted of 94 children with CH aged more than 4 months under follow up in Isfahan endocrine research center; the control group included 450 healthy infants underwent routine neonatal hearing screening in a private hospital. First, Otto Acoustic Emission (OAE) test was performed, and in the case of being abnormal, then auditory brain stem response (ABR) test was conducted. Children with abnormal ABR were considered to have hearing impairment. Findings: The prevalence of hearing impairment was not significantly different between children with CH and controls (3.2% vs. 0.2%, respectively; p>0.05). The mean age of beginning the treatment for CH was not significantly different between children with or without hearing impairment (13.6±8.3 vs. 16.4±8.05 days, respectively; p>0.05).The mean T4 and TSH was not significantly different between children with CH with and without hearing impairment (5.6±4.2 mg/dl and 133.7±80.3 MIU/l vs. 6.2±3.7 mg/dl and 116.5±92.1 MIU/l, respectively; p>0.05). Conclusion: We did not document any difference in the prevalence of hearing impairment in children with CH and controls; this finding might be because of limited number of subjects studied and the short duration of follow up. There was no difference neither between the age of beginning the treatment for CH and hearing impairment, nor between the mean T4 and TSH at birth and hearing impairment. Hearing loss has no relationship with age at treatment onset and primary T4 and TSH level at diagnoses. © 2007, Isfahan University of Medical Sciences(IUMS). All rights reserved.
