تاریخ انتشار: ۲۰۲۰/۰۹/۲۲
مطالعات حقوق خصوصی (25885618)(3)pp. 627-645
در فقه و حقوق ایران و فرانسه ایقاع، پدیدۀ غریبی نیست و دو واژۀ عقد و ایقاع در کنار هم نشان از ریشههای عمیق این دو نهاد دارد. اما آنچه در فرانسه، نظر دکترین را از قرن نوزدهم به خود جلب کرده، نقش آن در ایجاد تعهدات است. بهعبارتی هر ایقاع آثاری دارد، اما در اینکه آیا ایقاع میتواند تعهد ایجاد کند و منبع تعهد باشد، تردید وجود داشت. در سال 2016 با اصلاحات قانون مدنی فرانسه، اولاً عنوانی به نام منابع تعهدات مطرح شده و ثانیاً تدوین ایقاع در قسمت منابع تعهدات در کنار عقد و مسئولیت مدنی و به عنوان یکی از اعمال حقوقی در کنار وقایع حقوقی، نویدبخش طرح ایقاع بهعنوان یکی از منابع یکطرفه برای ایجاد تعهدات دوطرفه است که دستاورد نوینی در حقوق تعهدات بهشمار میرود. در حقوق ایران ایقاع موجد تعهد بهعنوان یک نظریۀ کلی مطرح نشده، اما مصادیقی در قانون مدنی هست که بهنظر میرسد میتوان وجود آنها را بهعنوان مصادیقی برای پذیرش نظریۀ تعهدات ایقاعی هرچند بهصورت استثنایی مطرح کرد. مطالعۀ حقوق فرانسه بهعنوان یکی از نظامهای حقوقی نوین در طرح نظریۀ کلی ایقاع بهعنوان منبع تعهد، میتواند در این زمینه راهگشا برای طرح نظریۀ کلی در حقوق ایران باشد که در این مقاله به شیوۀ تطبیقی انجام خواهد گرفت.
تاریخ انتشار: ۲۰۱۹/۰۳/۲۱
مطالعات حقوق خصوصی (25885618)(1)pp. 159-176
یکی از مباحث حقوق مسئولیت مدنی فرانسه، «مسئولیت مدنی ناشی از عمل مجرمانۀ دیگری» است. در سیستمهای حقوقی قاعده این است که مسئولیت کیفری شخصی و فردی است و مسئولیت ناشی از عمل دیگری منتفی است. اما بهنظر میرسد پذیرش مسئولیت مدنی ناشی از عمل مجرمانۀ دیگری امکان دارد و حتی در سیستمهایی که مسئولیت «کیفری» ناشی از عمل غیر را بهکار میبرند، در واقع منظور نوعی مسئولیت «مدنی» ناشی از عمل مجرمانۀ دیگری است نه مسئولیت «کیفری». ازاینرو میتوان مسئولیت مدنی ناشی از عمل مجرمانۀ دیگری را بهعنوان یک ضرورت در سیستم حقوقی ایران طرح کرد. از سویی مادۀ 142 ق.م.ا سبب این شبهه است که آیا تحمیل مسئولیت کیفری به معنای دقیق آن بر عهدۀ دیگری ممکن است یا نه. جای مسئله در ادبیات حقوق تعهدات و حقوق کیفری ایران خالی است که در این مقاله به شیوۀ تطبیقی و با کمک حقوق فرانسه به بررسی این موضوع پرداخته خواهد شد.
تاریخ انتشار: ۲۰۱۹/۱۲/۲۲
مطالعات حقوق خصوصی (25885618)(4)pp. 733-752
گاهی فعل زیانبار میتواند همزمان به فعل ناشی از فعل شخصی، فعل غیر یا فعل شیء توصیف شود. در این حالت در حقوق فرانسه این سؤال مطرح شده که آیا زیاندیده میتواند به اصول و مقررات هر سه مسئولیت استناد کند یا باید یکی را برگزیند و آیا دادگاه باید یکی را برگزیند و کدام مسئولیت و مستندات آن بر دیگری مقدم است. بنابراین یکی از مصادیق جمع و اختیار در مسئولیت مدنی، بحث تعیین قلمرو مسئولیت ناشی از فعل شخصی، فعل غیر و فعل شیء است. هر سه نوع مسئولیت امروزه به قاعده تبدیل شده و نیاز است تا حدود قلمرو هر یک تعیین شود. در کتابهای حقوق تعهدات فرانسه بهصورت پراکنده به موضوع اشاره شده و از استقرا در این موارد میتوان قواعد کلی در خصوص موضوع پیدا کرد. در حقوق ایران دکترین به این موضوع نپرداخته و مطالعة آن در حقوق فرانسه میتواند زمینة طرح آن را در ایران فراهم سازد که به شیوة تطبیقی مطالعه خواهد شد.
تاریخ انتشار: ۲۰۱۸/۰۶/۲۲
مطالعات حقوق خصوصی (25885618)(2)pp. 363-381
ویرانی اقتصادی و فرهنگی در برخی خانوادهها موجب ازدیاد افراد ولگرد و رها در جامعه میشود که نمونهای از آن کارتنخوابها هستند. این اشخاص معمولاً صغیر، مجرم یا بیماران روانیاند. ولگردی و سرگردانی این اشخاص در جامعه زمینهساز بروز جرائم و خطرهایی است که قوانین دنیا را به سمت جرمانگاری این پدیده سوق داده، اما در مورد جبران خسارات ناشی از فعل این اشخاص معمولاً سیاستی اتخاذ نشده است. یکی از نگرانیهای حقوق امروزی مسئلۀ جبران خساراتی است که در جامعه از سوی اشخاص بالقوه خطرآفرین مانند افراد بیمار و محجور یا جوانان خلافکار یا اشخاص ولگرد رخ میدهد که بهصورت افراد خطرناک در جامعه بدون سرپرست رها شدهاند. در مواردی اشخاص حقیقی یا حقوقی عهدهدار نگهداری از این اشخاص هستند که در حقوق فرانسه مشمول مادۀ 1242 و در ایران مشمول مادۀ 7 قانون مسئولیت مدنی بوده و اشخاص مزبور با شرایطی مسئول جبران چنین خساراتی خواهند بود. اما بخشی از این خسارات در شرایطی رخ میدهد که هیچ شخص حقیقی یا حقوقی عهدهدار نگهداری از این اشخاص نبوده و سؤال اساسی این است که آیا زیاندیگان این بخش از خسارات به حال خود رها خواهند شد یا میتوان شخص حقوقی مانند دولت را مسئول جبران چنین خساراتی دانست. در حقوق فرانسه براساس یک نظر میتوان در شرایط کنونی از دولتها انتظار داشت جبران چنین خساراتی را تقبل کنند. این ایده در حقوق ایران طرح نشده است، اما میتوان با کمک حقوق فرانسه مسئلۀ مزبور را بررسی کرد.
تاریخ انتشار: ۲۰۱۷/۰۶/۲۲
مطالعات حقوق خصوصی (25885618)(2)pp. 379-397
اصولاً در تعیین مسئول جبران خسارت، فعل زیانبار شخص نقش اصلی را دارد. اما در مواردی یکی از قواعد تعیین مسئول در حقوق فرانسه، تعیین مسئول بر مبنای مالکیت یا نگهداری از اشیاست که این موضوع در حقوق فرانسه، سبب طرح قاعدۀ مسئولیت مدنی ناشی از اشیا شده است. در حقوق فرانسه مسئولیت ناشی از حیوان و مسئولیت ناشی از ویرانی ساختمان و مسئولیت ناشی از تصادفات، مصادیقی از مسئولیت ناشی از اشیا هستند و دکترین از این مصادیق و به کمک بند 1 مادۀ 1242 ق.م.ف «اصل مسئولیت ناشی از اشیا» را استنباط کرده است. در حقوق ایران نیز چنین مصادیقی وجود دارد، ولی قاعدۀ کلی مانند مادۀ 1242 ق.م.ف وجود ندارد. بهنظر میرسد دکترین در حقوق ایران میتواند اقدام به طرح قاعدۀ مسئولیت مدنی ناشی از اشیا کند که در این مقاله با توجه به فقه، به شیوهای تطبیقی و با استفاده از حقوق فرانسه بررسی خواهد شد.
تاریخ انتشار: ۲۰۱۷/۰۳/۲۱
مطالعات حقوق تطبیقی (1735496X)(1)pp. 385-411
همواره بخشی از خسارات معلول عمل کارآموزان بیتجربهای است که در مشاغل متفاوت نزد استادکاری مشغول یادگیری حرفهای هستند. در حقوق برخی از کشورها مانند فرانسه، یکی از مصادیق مسئولیت مدنی ناشی از عمل غیر، مسئولیت کارفرمایان و صنعتگران ناشی از فعل زیانبار کارآموزانی است که نزد ایشان در حال یادگیری اطلاعات حرفهای هستند. یکی از مشکلات چنین سیستمهایی تعیین ماهیت این مسئولیت است. این مسئولیت میتواند نوعی مسئولیت مراقب نسبت به اعمال شخص تحت مراقبت، مانند مسئولیت سرپرست نسبت به طفل، بهشمار آید و نیز میتواند نوعی مسئولیت تبعیتی، مانند مسئولیت کارفرما نسبت به فعل کارگر، شمرده شود. طبیعی است که تعیین حکم در خصوص این مسئله آثار متفاوتی از نظر بار اثبات تقصیر خواهد داشت. در حقوق ایران در قانون مدنی و مسئولیت مدنی به این مسئولیت اشارهای نشده است. بهنظر میرسد تعیین رژیم حقوقی حاکم بر این مسئولیت تا حدودی به تعیین ماهیت چنین مسئولیتی وابسته است که در این مقاله به کمک حقوق فرانسه این موضوع بررسی خواهد شد.
تاریخ انتشار: ۲۰۱۶/۰۹/۲۲
مطالعات حقوق خصوصی (25885618)(3)pp. 475-494
تروریسم یکی از شومترین پدیدههایی است که امروزه به صورت ناجوانمردانه مانند طاعونی زندگی اشخاص بیگناه را تهدید کرده و چهرۀ انسانیت را خدشهدار نموده است. پدیدهای که همواره بوده، اما امروزه چهرۀ خاصی یافته و شیوع آن زنگ هشداری برای جوامع است. برخورد با این پدیدۀ زشت اصولاً در حقوقهای کیفری دنیا مطرح شده است. اما این پدیده عدهای را متحمل خسارات شدیدی کرده است که در فرانسه به «فراموششدگان تروریسم» مشهور شدهاند. امروزه این پدیده جای خود را در میان مباحث مسئولیت مدنی نیز باز کرده و این پرسش مطرح شده است که چه شخصی باید این خسارات را جبران سازد که در این مقاله برای تعیین مسئول جبران چنین خساراتی با کمک حقوق فرانسه مطالبی ارائه میشود.
تاریخ انتشار: ۲۰۱۶/۰۳/۲۰
مطالعات حقوق تطبیقی (1735496X)(1)pp. 367-383
فعل ناشی از اشیا مانند فعل زیانبار انسان میتواند موجب مسئولیت کسانی شود که آنها را در اختیار دارند. قانون مدنی فرانسه در زمان تصویب خود، اصل کلی مسئولیت ناشی از اشیا را پیشبینی نکرد و تنها در مواد 1385 و 1386، مسئولیت خسارات ناشی از حیوانات و ساختمانها را لحاظ نمود. اما در اواخر قرن نوزدهم، بر مبنای تفسیر بند 1 مادۀ 1384 این قانون، این اصل در قلمرو مسئولیت قرار گرفت. در حقوق ایران نیز مواد 333، 334 قانون مدنی، همچنین موادی از قانون مجازات اسلامی مانند 511، 512، 514، 515، 518، 522، 528 و 534 و مادۀ 1 قانون بیمۀ اجباری مسئولیت مدنی دارندگان وسایل نقلیۀ موتوری زمینی در مقابل شخص ثالث به شناسایی این مسئولیت پرداخته است؛ بدون آنکه به اوصاف شیء در ایجاد مسئولیت بپردازد. هدف از تنظیم این مقاله آن است که با مطالعۀ تطبیقی بیان گردد. در مسئولیت شیء، تفاوتی نمیکند شیء جاندار یا بیجان، خطرناک یا غیرخطرناک، منقول یا غیرمنقول و ساکن یا متحرک باشد؛ حتی ضرورتی ندارد شیء از جانب انسان هدایت و اداره شده باشد و در صورت وجود ارکان مسئولیت مدنی، فعل زیانبار شیء میتواند سبب مسئولیت دارندگان آن شود.
تاریخ انتشار: ۲۰۱۵/۰۹/۲۳
مطالعات حقوق خصوصی (25885618)(3)pp. 505-523
در حقوق قدیم دولت مسئولیت مدنی نداشت، ولی بهتدریج در میان رژیمهای حقوقی به این مسئولیت اشاره شده است. در حقوق ایران مسئولیت مدنی دولت ظاهراً در مادۀ 11 ق.م.م مطرح شده که از یکی از تئوریهای کهنۀ قرن نوزدهم اقتباس شده است، ولی مطالعه و تحلیل مادۀ یادشده نشان میدهد که مسئولیت مدنی دولت بر مبنای این ماده بهسهولت قابل پذیرش نیست.امروزه در حقوق فرانسه مسئولیت مدنی دولت بهعنوان یک اصل مطرح، و مسئولیت شخصی، مسئولیت ناشی از عمل غیر و مسئولیت ناشی از اشیا و حتی مسئولیت دولت نسبت به اعمال قوای قضائیه و مقننه پذیرفته شده است.در حقوق ایران هم لایحهای در این زمینه ارائه شده بود که در صورت تصویب میتوانست تا حدودی نواقص حقوق ایران را رفع نماید، ولی این لایحه به فراموشی سپرده شد که در این نوشتار با مطالعۀ تطبیقی بررسی خواهد شد.
تاریخ انتشار: ۲۰۱۴/۱۲/۲۲
مطالعات حقوق خصوصی (25885618)(4)pp. 633-651
اشخاص حقوقی میتوانند مسئول جبران خسارت باشند. از نظر تحلیلی، اشخاص حقوقی نیز میتوانند مسئول عمل دیگری بهشمار آیند. این اشخاص میتوانند مسئول عمل کارکنان و کارگران خویش باشند و این مسئولیت در حقوق فرانسه تابع بند 5 مادۀ 1384 ق.م.ف و در حقوق ایران مشمول مادۀ 12 ق.م.م یعنی مسئولیت کارفرما ناشی از عمل کارگر است. این مسئولیت بحث تازهای ندارد، اما در کتابهای جدید مسئولیت مدنی گاه به نوع دیگری از مسئولیت یعنی مسئولیت شخص حقوقی ناشی از عمل ارگان ادارهکننده برخورد میکنیم که به نظر عدهای مسئولیت خاصی بوده، مشمول مسئولیت کارفرما ناشی از عمل کارگر نیست و تا حدودی موضوع نوینی است که در قوانین ما مطالب چندانی دربارۀ آن وجود ندارد. در این مقاله این موضوع جدید به شیوۀ تطبیقی بررسی خواهد شد.
تاریخ انتشار: ۲۰۱۳/۰۲/۱۹
مطالعات حقوق خصوصی (25885618)(4)pp. 249-268
یکی از اصول مسئولیت ها اعم از مسئولیت اخلاقی و حقوقی این است که مسئولیت شخصی است . قاعده فقهی "وزر" دلالت بر این دارد که اصل بر مسئولیت شخصی است . حال در مواردی که اصولا" مسئولیت در یک تعهد مالی خلاصه می گردد ; مانند مسئولیت مدنی که بر ذمه فاعل فعل زیان بار، تعهد به جبران ضرر ایجاد می گردد، بر اصل شخصی بودن مسئولیت ، استثنائاتی وارد شده و مسئولیت ناشی از عمل غیر مطرح گردیده است . در حقوق فرانسه تا سال 1991 مسئولیت مدنی ناشی از فعل غیر استثنایی تلقی می گردید و ماده 1384 قانون مدنی فرانسه در مورد برخی از مصادیق مسئولیت ناشی از عمل غیر به صورت استثنایی و محدود تفسیر می گردید. از این سال به بعد با تفسیر دیوان استثنا تبدیل به قاعده شد . در حقوق ایران نیز مصادیق مسئولیت مدنی ناشی از عمل غیر چنان گسترده است که بعید نیست بتوان قانونگذار را به ارائه یک فرمول کلی از مسئولیت ناشی از عمل غیر سوق داد که در این مقاله همراه با مطالعه تطبیقی مورد بررسی قرار می گیرد.
تاریخ انتشار: ۲۰۱۳/۱۰/۲۳
مطالعات حقوق خصوصی (25885618)(3)pp. 203-221
یکی از تحولات حقوق مسئولیت مدنی، بحث جمعی شدن این گونه مسئولیتهاست. گذشته از تقسیم خطرات، مسئولیت مدنی در زمانهای گذشته جمعی بوده و نتیجۀ فعل زیانبار بر همه قبیله و خانوادۀ فاعل آن فعل تحمیل میشده است. سپس با رشد تمدنها وبا ظهور اصل شخصی بودن، مسئولیت مدنی جنبۀ شخصی به خود گرفت. اما اخیراً در زمان معاصر زمزمههایی از جمعی شدن مسئولیت به شیوۀ علمی بهگوش میرسد که رد پای این ایده را در برخی از قوانین جدید هم میتوان دید.در این راستا بحثهای دیگری مانند اجتماعی کردن خطرات یا اجتماعی کردن جبران خسارت و آثاراین مباحث بر حقوق مسئولیت مدنی قابل تأمل است که با مطالعۀ تطبیقی در حقوق فرانسه در این مقاله مورد بررسی قرار خواهد گرفت.
تاریخ انتشار: ۲۰۱۲/۰۳/۲۰
مطالعات حقوق خصوصی (25885618)(1)pp. 233-251
یکی از مباحث حقوق تعهدات مساله تعیین ماهیت تعهدات و مسئولیت های ناشی از حمل و نقل جاده ای دوستانه مسافر است که در برخی از رژیم های حقوقی نسبت به آن نظراتی جالب ارائه شده است. در حقوق ایران نسبت به حمل و نقل دوستانه مطلبی به چشم نمی خورد و تجزیه و تحلیل مساله منوط به بررسی حمل و نقل حرفه ای است که برغم اینکه در ظاهر آسان به نظر می رسد اما اندکی تامل نشان می دهد که تعیین رژیم حقوقی حاکم بر حمل و نقل جاده ای مسافر بسیار پیچیده است. فقدان حکمی صریح در قانون مدنی و دیگر منابع به ابهامات وضعیت حقوقی حمل و نقل مسافر دامن می زند که در این مقاله با استفاده از منابع داخلی و منابع موجود در حقوق فرانسه به تجزیه و تحلیل آن پرداخته می شود.
Mohammadian, Manijeh,
Jalouti, Nima,
Yazdanian, A.R.,
Keykha, Elham,
Hajisadeghi, Samira Publication Date: 2025
Frontiers in Oral Health (26734842)
Background and aim: Dentin hypersensitivity (DH) has long been a challenging condition, with many treatment methods showing limited success. However, the emergence of laser therapy, particularly the significant potential of diode laser (DL) and sodium fluoride (NaF) varnish, has sparked new hope. This research is a significant step towards a more effective treatment for DH, aiming to evaluate the promising potential of DL in treating DH, both independently and in combination with fluoride varnish. By delving into this research, you are investing your time in understanding a crucial advancement in the field of dentistry. Methods: A comprehensive search was conducted across the PubMed, Scopus, and Web of Science databases, including studies published up until May 2024. Randomized clinical trials that assessed DH using a visual analog scale (VAS) score were included. Data on participant demographics, treatment types, and VAS scores were extracted by two reviewers. The risk of bias was assessed using the revised Cochrane risk-of-bias instrument for randomized trials (RoB-2). Result: Three studies met the inclusion criteria, comparing NaF varnish, DL, and their combination. Both DL and the combination of DL and NaF varnish were more effective than NaF varnish alone in reducing DH. The combined treatment showed marginally superior outcomes compared to DL alone. Significant reductions in DH were observed across all treatment groups, with the combination therapy demonstrating the most substantial and consistent improvement. Conclusion: Diode laser therapy, particularly when combined with NaF varnish, represents a promising treatment approach for DH, offering superior efficacy over NaF varnish alone. These findings suggest that combination therapy may provide longer-lasting relief, with implications for improving clinical outcomes in DH management. 2025 Mohammadian, Jalouti, Yazdanian, Keykha and Hajisadeghi.
Publication Date: 2025
BMC Oral Health (14726831)(1)
Tooth discoloration is a common cosmetic concern, often addressed using whitening dentifrices (WDFs). This updated systematic review and meta-analysis aimed to assess the effectiveness of WDFs in decreasing tooth surface discoloration compared to regular dentifrices (RDFs). A comprehensive search of multiple electronic databases identified 14 randomized controlled trials (RCTs) meeting the inclusion criteria. The meta-analysis showed that WDFs significantly reduced both the area and intensity of stains, with 94.45% and 77.78% efficacy, respectively. Studies incorporating adjunctive chemical agents in WDFs showed enhanced stain reduction. Despite significant heterogeneity (I2 = 91%) among the studies, the results consistently favored WDFs over RDFs. Low publication bias was detected, and sensitivity analyses confirmed the robustness of the findings. These results endorse the utilization of WDFs for managing extrinsic tooth stains, though further research is needed to standardize methodologies and assess long-term effects. © The Author(s) 2025.
Tahmasebi, Elahe,
Raeisolvaezin, Kiyavash,
Yazdanian, A.R.,
Hajisadeghi, Samira,
Mirnejad R. Publication Date: 2025
The Open Dentistry Journal (18742106)
Introduction: As the carcinogenic properties of formocresol spark global concern, the exploration of safer alternatives becomes paramount in pediatric dentistry. This study assesses the efficacy of Citrullus colocynthis extract, recognized for its potent anti-inflammatory and antimicrobial qualities, as a potential substitute in pulpotomy treatments. Methods and Materials: Employing a controlled experimental design, eight New Zealand white rabbits underwent pulpotomy using either the traditional formocresol or the novel Citrullus colocynthis extract. Following the treatments, comprehensive histological assessments were performed to evaluate inflammatory responses, tissue necrosis, and morphological changes in pulp cells. Data analysis was conducted with SPSS, utilizing Chi-square and Mann Whitney tests to ascertain statistical significance. Results: Statistically significant disparities were evident in the levels of inflammation, infiltration of inflammatory cells, and morphological changes of pulp tissue cells, with the Citrullus colocynthis extract group showing more pronounced adverse effects. In contrast, rates of necrosis did not differ significantly between the two groups. Conclusion: Despite its notable anti-inflammatory properties, Citrullus colocynthis extract induced significant adverse cellular reactions in pulpotomy applications. While promising as a therapeutic agent, its potential cellular toxicity suggests a cautious approach to clinical usage in dental treatments, warranting further investigation and optimization for safety. © 2025 The Author(s). Published by Bentham Open.
Kavousinejad, Shahab,
Yazdanian, A.R.,
Kanafi, Mohammad Mahboob,
Tahmasebi, Elahe Publication Date: 2024
Diagnostics (20754418)(17)
Lateral cephalometric radiographs are crucial in dentistry and orthodontics for diagnosis and treatment planning. However, their use in forensic identification, especially with burned bodies or in mass disasters, is challenging. AM (antemortem) and PM (postmortem) radiographs can be compared for identification. This study introduces and evaluates a novel algorithm for extracting cranial patterns from digital lateral cephalometric radiographs for identification purposes. Due to the unavailability of AM cephalograms from deceased individuals, the algorithm was tested using pre- and post-treatment cephalograms of living individuals from an orthodontic archive, considered as AM and PM data. The proposed algorithm encodes cranial patterns into a database for future identification. It matches PM cephalograms with AM records, accurately identifying individuals by comparing cranial features. The algorithm achieved an accuracy of 97.5%, a sensitivity of 97.7%, and a specificity of 95.2%, correctly identifying 350 out of 358 cases. The mean similarity score improved from 91.02% to 98.10% after applying the Automatic Error Reduction (AER) function. Intra-observer error analysis showed an average Euclidean distance of 3.07 pixels (SD = 0.73) for repeated landmark selections. The proposed algorithm shows promise for identity recognition based on cranial patterns and could be enhanced with artificial intelligence (AI) algorithms in future studies. © 2024 by the authors.
Askari, Mohammad,
Tavaf, Maryam Jadid,
Ghorbani M.,
Yazdanian, A.R.,
Moosazadeh Moghaddam M. Publication Date: 2024
Current Stem Cell Research and Therapy (1574888X)(1)
Background: Major injuries that are caused by trauma and cancer can not be repaired through bone remodeling. The goal of bone regeneration by tissue engineering approaches is to fabricate bone implants in order to restore bone structure and functions. The use of stem cells and polymer scaffolds provides the conditions for tissue regeneration based on tissue engineering. Objective: This study aimed to fabricate a combined matrix of poly(lactide-co-glycolide) (PLGA) and propolis extract, which is a mixture of pollen and beeswax collected by bees from certain plants and has long been used in traditional herbal medicine, to promote the osteogenic differentiation of human adipose-derived mesenchymal stem cells (AD-MSCs). Methods: The scaffold was fabricated through electrospinning and was immersed in a propolis extract solution. Then, AD-MSCs were cultured and differentiated into the osteogenic lineage. The cell viability on the scaffold was evaluated by MTT assay. Osteogenic differentiation of the seeded stem cells was detected by evaluating calcium content, alkaline phosphatase (ALP) activity, and the expression of bonespecific genes. Results: The viability of cells was not affected by propolis-coated and uncoated fabricated scaffolds, while higher calcium content, ALP activity, and expression of RUNX-2, type I collagen, osteocalcin, and osteonectin were observed in cells differentiated on propolis-coated PLGA scaffold on days 7, 14, and 21 of differentiation compared to PLGA scaffold. Conclusion: The results of this study showed that the presence of propolis in the scaffold could lead to better cell attachment and strengthen the osteoinduction process in stem cells. © 2024 Bentham Science Publishers.
Vazifehdoust, Soheil,
Shalizar-Jalali, Ali,
Nourani, Mohammad Reza,
Moosazadeh Moghaddam M.,
Yazdanian, A.R. Publication Date: 2024
Veterinary Research Forum (20088140)(9)
This study aimed to investigate the effects of zoledronic acid (ZA) and antibacterial CM11 peptide on the osteoinduction and antibacterial properties of bioactive glass (BG). The bioactive glass/gelatin (BG/Gel) composite was synthesized using the sol-gel method. The 2-x minimum inhibitory concentration of the peptide and 4.00 mg mL-1 of ZA were added to the BG/Gel during fabrication. The BG/Gel composite morphological and structural characteristics and anti-bacterial activities were analyzed using Fourier transform infra-red spectroscopy, scanning electron microscopy and disk diffusion test, respectively. The release of the peptide and ZA from BG/Gel was measured using ultra-violet spectroscopy. After 14 days, the effects of the peptide/ ZA-containing BG/Gel (PZ-BG/Gel) on the growth and differentiation of mesenchymal stem cells were evaluated using 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide, calcium and alkaline phosphatase assays, immunocytochemical staining for osteocalcin (OCN) and real-time polymerase chain reaction for OCN, type I collagen, bone morphogenetic protein 2 and Runt-related transcription factor-2 genes. The disk diffusion test showed the anti-microbial activity of the scaffold against multi-drug-resistant isolates of Pseudomonas aeruginosa and Staphylococcus aureus. Analyses showed a significantly higher level of stem cells differentiation into the osteo-genic cells in PZ-BG/Gel scaffold compared to BG/Gel scaffold alone. Accordingly, osteoblast markers were significantly increased in comparison with the control. In conclusion, the osteo-induction and antibacterial properties of BG-based scaffold can be improved using ZA and CM11. © 2024 Urmia University. All rights reserved.
Tahmasebi, Elahe,
Mohammadi, Mehdi,
Yazdanian, A.R.,
Alam, Mostafa,
Abbasi, Kamyar Publication Date: 2023
Journal of Basic Microbiology (0233111X)(9)
The oral antimicrobial and cytotoxic properties of green synthesized novel titanium dioxide nanoparticles (TiO2 NPs) using Iranian propolis extracts were investigated on oral bacteria and fibroblast cells. In this study, propolis was sampled, and alcoholic extracts were prepared. The TiO2 NPs were biosynthesized using propolis extracts. The synthesized TiO2 NPs were characterized by scanning electron microscope (SEM), X-ray diffraction analysis, energy-dispersive X-ray (EDX), Fourier transform infrared spectroscopy (FTIR), dynamic light scattering, ultraviolet–visible (UV–Vis), transmission electron microscope, Brunauer–Emmett–Teller, and zeta potential. MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide), minimal inhibitory concentration, minimum bactericidal concentration, minimum fungicidal concentration, biofilm formation, and degradation tests were studied to clarify the oral antimicrobial properties of green synthesized TiO2 NPs. According to the FTIR analysis, the propolis extract contained flavonoids and phenolic compounds in addition to TiO2 NPs. Additionally, UV-Vis revealed that intense bands had formed NPs. EDX spectra and SEM images revealed that the stabilizing agent was in perfect quasi-spherical shapes around 21 nm. An EDX spectrum was used to verify the presence of titanium and oxygen. There were no significant cytotoxicity effects. The antibacterial results showed that Pro1TiO2 (Khalkhal sample) had better effects than Pro2TiO2 (Gilan sample) and TiO2 NPs. The present study presents a new process for synthesizing TiO2 NPs from propolis extracts with less toxic effects and user-friendly, eco-friendly, and economical materials. Pro1TiO2 NPs may be considered the best candidate for clinical application. © 2023 Wiley-VCH GmbH.
Moghaddam A.,
Khayatan D.,
Esmaeili Fard Barzegar P.,
Ranjbar R.,
Yazdanian, A.R. Publication Date: 2023
International Journal of Environmental Science and Technology (17351472)(5)
The indirect ingestion of pharmaceuticals in water has been proven to have adverse effects on humans according to a number of studies. Pharmaceutical compounds (PhCs) are found in open waters, and drinking these types of waters primarily from raw sewage and wastewater effluents. Effective pharmaceutical removal during drinking water and wastewater treatment is a crucial part of ensuring that pharmaceuticals are effectively removed. There are various excipients and PhCs that may have chronic effects on different communities. Examples include neuroprotective agents, NSAIDs (nonsteroidal anti-inflammatory drugs), diuretics, and antibiotics. Novel procedures such as biodegradation may assist in minimizing or preventing these effects. There is a correlation between the concentrations of each drug group and the seasons or common diseases in particular areas, which emphasizes the need to eliminate pharmaceutical compounds. Organic compounds are broken down into smaller and simpler molecules through biodegradation, which uses enzymes produced by living microbes. The biodegradation of pharmaceuticals usually removes them from the environment, especially those resistant to hydrolysis and photodegradation. Many microorganisms, including bacteria, fungi, and algae, can perform this function. As a result, they are integral parts of the pharmaceutical degradation in the environment. Also, the degradation of PhCs from pharmaceutical wastewater (PW) can be achieved using various biological processes, such as membrane bioreactors (MBRs), conventional activated sludge treatment (CAS), moving bed biofilm reactors (MBBRs), and constructed wetlands. In this review article, the conventional and advanced methods of removing pharmaceutical compounds from surfaces in recent decade studies (2010–2022) are discussed. © 2023, The Author(s) under exclusive licence to Iranian Society of Environmentalists (IRSEN) and Science and Research Branch, Islamic Azad University.
Rahbar, Mahdi,
Pourtarrah, Mojtaba,
Tahmasbi, Elaheh,
Bakhtiari, Afsaneh,
Yazdanian, A.R. Publication Date: 2023
Malta Medical Journal (18133339)(2)
Background and aim As the number of elderly people visiting dental clinics increases, it is essential to have sufficient information on the correct treatment as well as the appropriate treatment plan for these patients. Therefore, the present study aimed at reviewing the most important restorative considerations for the elderly. Method In this systematic review study, databases such as Pubmed, Embase, Web of Science, Scopus, ProQuest, Google scholar, as well as Iranian databases were searched with the keywords of elderly dentistry and restorative considerations. Inclusion criteria were original articles and reviews related to restorative dentistry considerations for the elderly without a time limit and being written in either English or Persian. In order to combine the results of the research, a thematic content analysis method was applied. Results The total number of documents recovered was 4208, the number of duplicate documents was 2042, and the number of documents reviewed was 17. The most important considerations related to the elderly included giving due attention to medical and social conditions, medication use, type of restorative teeth, level of restoration involved, use of dentures, age and gender, oral cancer screening, tooth decay education and prevention, and oral hygiene. The most important considerations related to restorative methods and materials were applying minimally invasive methods such as ART, more durable restorative materials, and giving due attention to the aesthetic and non-aesthetic needs of the elderly in choosing restorative materials. The most important considerations related to dentists were the differences in applying restorative methods and materials by experienced dentists in comparison younger dentists and the rate of referral of elderly people to dental centers. Conclusion The most important dental considerations of the elderly are using minimally invasive methods and restorative materials with easy maintenance which are washable according to their social, economic, medical, gender, and age conditions. It is also necessary to consider the prevention of tooth decay and provide the required training for families and their caregivers in nursing homes. The elderly people are also required to avoid change their dentists frequently to maintain their oral health. © 2023, University of Malta. All rights reserved.
Ramezanalizadeh, Hamed,
Ranjbar R.,
Yazdanian, A.R.,
Tahmasebi, Elahe,
Salesi, Mahmood Publication Date: 2023
Optik (00304026)
Noteworthy, potential materials such as L-cysteine and Ag nanoparticles display promising and favorable features in target applications. In the present study, a novel nanohybrid containing L-cysteine-modified graphene oxide (CysGO) decorated with silver nanoparticles (Ag/CysGO) was facilely fabricated through an ultrasound route and characterized by multiple techniques. The antibacterial activity of CysGO and Ag/CysGO nanomaterials was investigated separately for gram-positive and gram-negative bacteria degradation. Owing to the significant antibacterial properties of Ag nanoparticles, Ag/CysGO demonstrated remarkable antibacterial performance for different bacteria. Ag/CysGO also was utilized for the photocatalytic degradation of MB pollutants to corresponding safe materials. Kinetic evaluations for the photocatalytic degradation of MB over prepared catalysts under visible light illumination have been investigated. Based on the reusability tests, the prepared nanohybrid demonstrates the reusability activity without a substantial activity loss. Overall, Ag/CysGO nanohybrid can be an efficient nanomaterial for environmentally friendly photocatalytic degradation approaches. © 2023 Elsevier GmbH
Yazdanian, A.R.,
Barzegar, Peyman Esmaeili Fard,
Ranjbar R.,
Tahmasebi, Elahe,
Tebyaniyan, Hamid Publication Date: 2023
Veterinary Medicine and Science (20531095)(2)
Background: One of the most common causes of pneumonia is Pseudomonas aeruginosa (P. aeruginosa). As with other microbial pathogens, this bacterium tends to develop resistance to various antibiotics. Amikacin and erythromycin, which are from the aminoglycoside and macrolide antibiotic families, are used to treat respiratory infections caused by P. aeruginosa. Objectives: This study explored whether amikacin, erythromycin or a combination of both works better against P. aeruginosa acute lung infection. Methods: For this study, 32 rats were used. The trachea of rats was exposed aseptically and their lung was infected with P. aeruginosa through trachea. Then, according to the group, they received amikacin, erythromycin or a combination of both for 1 week. Finally, they were euthanised on the 3rd and 7th days post-infection. The macroscopic and microscopic evaluations of the lungs, kidney and liver were performed. The right lung was collected for in vivo bacteriological analysis. Results: The amikacin group (A group) had a statistically significantly lower macroscopic and microscopic scores than the other groups (p < 0.05). In vivo bacteriological test revealed that the A group had significantly lower lung bacterial load (p < 0.05). Conclusions: In summary, it was concluded that amikacin could help alleviate the respiratory infection caused by P. aeruginosa solely, and it was more effective than erythromycin. © 2022 The Authors. Veterinary Medicine and Science published by John Wiley & Sons Ltd.
Seyyed Hajizadeh, Yasamin,
Babapour, Ebrahim,
Harzandi, Naser,
Yazdanian, A.R.,
Ranjbar R. Publication Date: 2023
Evidence-based Complementary and Alternative Medicine (1741427X)
Background. Drug resistance is currently possible anywhere in the world. Due to the discovery of antimicrobials, medicine, and health have made tremendous advances over the past several decades. Aim. This research evaluated the antimicrobial and cytotoxicity effects of green synthesis of copper oxide nanoparticles (CuO NPs) on Lactobacillus acidophilus and human embryonic kidney 293 cells (HEK). Method and Materials. Propolis was sampled and extracted. Green synthesis of CuO NPs was synthesized and characterized using SEM, TEM, DLS, BET, and zeta potential methods. L. acidophilus (ATCC 4356) was used, and the antimicrobial tests were carried out at different concentrations (10≥ mg/ml). Moreover, the cytotoxicity was evaluated using an MTT assay on human embryonic kidney 293 cells (HEK). Results. Synthesized CuO NPs using propolis extracts from Khalkhal (sample 1) and Gillan (sample 2) showed -13.2 and -14.4 mV, respectively. The hydrodynamic sizes of well-dispersed samples 1 and 2 were 3124.9 nm and 1726.7 nm, respectively. According to BET analysis, samples 1 and 2 had 5.37 and 8.45 m2/g surface area, respectively. The surface area was decreased due to the addition of propolis extract, and the pore size was increased. CuO NPs of samples 1 and 2 were visible on SEM images with diameters ranging from 75 to 145 nm and 120 to 155 nm, respectively. Based on TEM analysis, the size of CuO particles was increased in samples 1 and 2. CuO NPs particles had narrow size distributions with evenly dispersed NPs on all sides. The cell viability of the CuO NPs of samples 1 and 2 after 24, 48, and 72 hours was greater than 50%. As a result of the MIC and MBC tests, it was determined that samples 1 and 2 had the same effect against L. acidophilus (0.0024 mg/ml). Biofilm formation and degradation of sample 1 were more efficient against L. acidophilus. Conclusion. There was no evidence of cytotoxicity in the samples. In addition, results showed that the green synthesized CuO NPs from Khalkhal propolis were effective against L. acidophilus. Thus, the green synthesized CuO NPs from Khalkhal propolis were the best candidates for clinical application. © 2023 Yasamin Seyyed Hajizadeh et al.
Yazdanian, A.R.,
Motallaei, Mohammad Nima,
Tahmasebi, Elahe,
Tebyaniyan, Hamid,
Alam, Mostafa Publication Date: 2022
BioMed Research International (23146133)
Multimicrobial infections caused by pathobionts are called dysbiotic multimicrobial illnesses. Commercial mouthwashes, such as chlorhexidine, have negative side effects that can prevent tooth decay and infection. The present study aimed to determine the antifungal, antibacterial, and cytotoxicity characteristics of the propolis extracts from different areas (Iran). The ethanolic extract of propolis was prepared. GC/MS carried out the characterization to determine the thymol, carvacrol, and menthol extracts, and also, total phenol and flavonoid were assed for all samples. The antimicrobial and antibiofilm effects were evaluated against S. mutans, S. mitis, S. salivarius, L. acidophilus, E. coli, S. aureus, and C. albicans. The cytotoxic effect of extracts was measured on human fibroblast cells by MTT test. The MIC values in mg mL-1 were ranged as follows: S. salivarius (0.003 to 0.048), S. mutans (0.003 to 0.029), S. mitis (0.007 to 0.058), L. acidophilus (0.007 to 0.117), C. albicans (0.014 to 0.234), E. coli (0.007 to 0.058), and S. aureus (0.007 to 0.058), while MBC were, respectively, S. mutans (0.007 to 0.058), S. salivarius (0.007 to 0.117), S. mitis (0.007 to 0.117), L. acidophilus (0.014 to 0.234), C. albicans (0.029 to 0.468), E. coli (0.014 to 0.234), and S. aureus (0.007 to 0.117). Cariogenic bacteria and Candida albicans were demonstrated to be resistant to propolis extracts. Therefore, propolis extracts may make good mouthwashes. © 2022 Mohsen Yazdanian et al.
Yazdanian, A.R.,
Karami, Shahryar,
Tahmasebi, Elahe,
Alam, Mostafa,
Abbasi, Kamyar Publication Date: 2022
Scanning (01610457)
The heavy casualties associated with mass disasters necessitate substantial resources to be managed. The unexpectedly violent nature of such occurrences usually remains a problematic amount of victims that urgently require to be identified by a reliable and economical method. Conventional identification methods are inefficient in many cases such as plane crashes and fire accidents that have damaged the macrobiometric features such as fingerprints or faces. An appropriate recognition method for such cases should use features more resistant to destruction. Forensic dentistry provides the most appropriate available method for the successful identification of victims using careful techniques and precise data interpretation. Since bones and teeth are the most persistent parts of the demolished bodies in sudden mass disasters, scanning and radiographs are unrepeatable parts of forensic dentistry. Forensic dentistry as a scientific method of human remain identification has been considerably referred to be efficient in disasters. Forensic dentistry can be used for either "sex and age estimation,""Medical biotechnology techniques,"or "identification with dental records,"etc. The present review is aimed at discussing the development and implementation of forensic dentistry methods for human identification. For this object, the literature from the last decade has been searched for the innovations in forensic dentistry for human identification based on the PubMed database. © 2022 Mohsen Yazdanian et al.
Yazdanian, A.R.,
Rostamzadeh, Pouya,
Alam, Mostafa,
Abbasi, Kamyar,
Tahmasebi, Elahe Publication Date: 2022
AMB Express (21910855)(1)
Dental caries and oral infections have become a widespread issue in the modern world. This study aimed to investigate the antibacterial, antifungal, and cytotoxicity characteristics of the extracts of Echinacea purpura, Arctium lappa, and the essential oil of Zataria multiflora as a potential herbal mouthwash. The essential oil of Z. multiflora leaves and the extracts of E. purpurea and A. lappa roots were prepared. The characterization was carried out by GC-MS and also, total phenol and flavonoid were assed for all three samples. The antimicrobial and anti-biofilm effects were evaluated against Streptococcus mutans, Streptococcus mitis, Streptococcus salivarius, Lactobacillus acidophilus, Escherichia coli, Staphylococcus aureus, and Candida albicans. The cytotoxic effect of the samples was evaluated on HEK 293 and HDFa cells by MTT test. Thymol and carvacrol contents in EO of Z. multiflora were measured at 31% and 42.2%, respectively. A. lappa had the lowest total phenolic and flavonoid value among the samples. On the other hand, the total phenolic content of Z. multiflora and the total flavonoid content of E. purpurea were the highest. The MIC values of Zataria, Arctium, and Echinacea against S. mutans were 0.011% v/v, 187.5 mg/ml, and 93.75 mg/ml, while MBC were 0.011% v/v, 375 mg/ml, and 187.5 mg/ml, respectively. The formulation showed bactericidal activity against S. mutans in the concentration of 5.86 mg/ml for Echinacea and Burdock extracts and 0.08 µl/ml for EO of Zataria. The formulation significantly affected microbial biofilm formation and induced biofilm degradation. The cell viability percentages were higher than 50% during 24 and 48 h. The formulation had a significant antimicrobial effect on cariogenic bacteria and C. albicans, with the lowest cytotoxic effects. Therefore, this formulation can be an appropriate candidate for mouthwash. © 2022, The Author(s).
Tahmasebi, Elahe,
Karami, Shahryar,
Hajisadeghi, Samira,
Tavallaie, Mahmood,
Yazdanian, A.R. Publication Date: 2022
Journal of Mazandaran University of Medical Sciences (17359279)(212)
Background and purpose: Dental and skeletal features, unlike soft tissues, remain unchanged in events where most body tissues are destroyed such as car accidents, plane crash, crimes, etc. Panoramic and lateral cephalometric radiographs can provide useful information about dental and cephalometric indicators in human identification. Materials and methods: A cohort retrospective study was carried out in five stages, including collecting the samples, using a specific tooth counting system, identifying the landmarks in panoramic radiographs and designing a dental formula, designing anatomical formula with cephalometric indicators and identifying operator errors, and matching and data analysis. Results: We studied 180 people, including 97 (54%) women and 83 men aged 15-59 (mean age= 25.5) years in Tehran. Average indexes of missing (M), filled (F), Root Canal Therapy (RCT) teeth, crown (C), (Body/Go-Go), (Mf-Mf/Mf-Go(R+L)), De, P, ER, Go in lateral Cephalometry, SNA, SNB, Basal, N-Ans-Me, Ans-Pns/Go-Me, and S-Go/N-Me were not significantly different between cases by comparing the graphs before and after treatments (P>0.05). Examination of average indices of implant and dilacerated teeth in general and without considering the number of teeth, did not show a significant difference when the pre/post-treatment graphs were compared (P>0.05). In examining the Co-Ans/Co-Gn, Go in panoramic graph, (S-N/S-Ba) and S-N-Ba, no significant difference was observed between the cases (P>0.05). Conclusion: Panoramic, lateral cephalometric graphs and designing creative formula can be used in human identification. © 2022, Mazandaran University of Medical Sciences. All rights reserved.
Seyyed Hajizadeh, Yasamin,
Harzandi, Naser,
Babapour, Ebrahim,
Yazdanian, A.R.,
Ranjbar R. Publication Date: 2022
Advances In Materials Science And Engineering (16878434)
The propolis produced by bees is used by them to protect their hives. The cavity inside the hive's walls is filled in during cold days to reduce entry points and mummify any intruders to ensure their survival. A current focus in nanotechnology and nanoscience is the green biosynthesis of nanoparticles (NPs) using biomaterials. Research on green methods for making metal oxide NPs is gaining momentum to safeguard the environment from the potential dangers associated with toxic chemicals. This study aimed to synthesize copper NPs (CuNPs) via propolis extraction, a novel application of nanoscience. The study was conducted under a range of pH, time conditions, and concentration ratios, and its properties were characterized by UV-Vis absorption spectra, XRD, and FTIR. An FTIR analysis revealed that compounds found in propolis extract could have an effect on the surface modification of the synthesized NPs. The propolis (Khalkhal) extract spectrum exhibited a sharp peak at 3422 cm-1, caused by free hydroxyl groups and their intra/intermolecular hydrogen bonds. There were sharp peaks at 2925, 1637, and 1515 to 1076 cm-1 associated with the C = O and C = C aromatic stretching frequencies. According to UV-Vis spectrophotometry investigation, CuO NPs exhibit a characteristic peak at 385 nm, showing significant surface plasmon resonance (SPR) with propolis (Khalkhal) extract. Furthermore, specific wavelengths of CuO NPs demonstrate peaks at 243, 292, and 350 nm for propolis (Gilan) extract. The green synthesis of CuNPs from Gilan and Khalkhal propolis can be an appropriate candidate for clinical applications such as drug delivery systems, drug formulation, and biomedical applications. © 2022 Yasamin Seyyed Hajizadeh et al.
Tahmasebi, Elahe,
Hakim, Lotfollah Kamali,
Yazdanian, A.R.,
Asadi, Amirali,
Garajei, Ata Publication Date: 2022
Cellular and Molecular Biology (01455680)(12)
This is the eighth most malignant tumor in the world, causing the highest incidence and malignancy rate of all cancers in the mouth and maxillofacial region. In cells, miRNAs regulate development, differentiation, proliferation, and differentiation, and miRNA expression is a better indicator of physiological status than DNA expression. miR-21, miR-132, miR-29a, miR-204, and miR-138 levels were measured in plasma from patients with primary OSCC and healthy controls. A Real Time-PCR technique was used to measure miR-21, miR-132, miR-29a, miR-29a, and miR-204 expression levels in plasma from 38 healthy and 38 people with primary OSCC. A standard distribution test and a CT unit were used to confirm the quantitative data on miRNA expression. Gene expression levels were compared between two groups of patients and healthy groups using a Mann-Whitney test and an unpaired t-test. MiR-21's median CT value was 29.68 in the OSCC group and 32.89 in the healthy group, and miR-29a's median CT value was 37.54 and 36.46 in the OSCC group and healthy group, respectively. Additionally, miR-132's CT values were 37.71 and 36.40, miR-138's CT value was 35.37 and 31.21, and miR-204's CT value was 36.44 and 36.17. The results showed that miR-21 expression levels increased significantly, while miR-29a, miR-132, and miR-138 (P < 0.05), and miR-204 expression levels did not differ significantly (P > 0.05). As a result of this study, the expression levels of microRNAs may be considered to diagnose OSCC at an early stage. It is essential to diagnose this disease early to improve treatment and patient health outcomes. Copyright: © 2022 by the C.M.B. Association. All rights reserved.
Yazdanian, A.R.,
Alam, Mostafa,
Abbasi, Kamyar,
Rahbar, Mahdi,
Farjood, Amin Publication Date: 2022
Frontiers in Bioengineering and Biotechnology (22964185)
The state-of-the-art approach to regenerating different tissues and organs is tissue engineering which includes the three parts of stem cells (SCs), scaffolds, and growth factors. Cellular behaviors such as propagation, differentiation, and assembling the extracellular matrix (ECM) are influenced by the cell’s microenvironment. Imitating the cell’s natural environment, such as scaffolds, is vital to create appropriate tissue. Craniofacial tissue engineering refers to regenerating tissues found in the brain and the face parts such as bone, muscle, and artery. More biocompatible and biodegradable scaffolds are more commensurate with tissue remodeling and more appropriate for cell culture, signaling, and adhesion. Synthetic materials play significant roles and have become more prevalent in medical applications. They have also been used in different forms for producing a microenvironment as ECM for cells. Synthetic scaffolds may be comprised of polymers, bioceramics, or hybrids of natural/synthetic materials. Synthetic scaffolds have produced ECM-like materials that can properly mimic and regulate the tissue microenvironment’s physical, mechanical, chemical, and biological properties, manage adherence of biomolecules and adjust the material’s degradability. The present review article is focused on synthetic materials used in craniofacial tissue engineering in recent decades. Copyright © 2022 Yazdanian, Alam, Abbasi, Rahbar, Farjood, Tahmasebi, Tebyaniyan, Ranjbar and Hesam Arefi.
Barzegar, Peyman Esmaeili Fard,
Ranjbar R.,
Yazdanian, A.R.,
Tahmasebi, Elahe,
Alam, Mostafa Publication Date: 2022
Materials Today Communications (23524928)
Periodontal disease is a persistent condition that damages tooth-related structures and causes tooth loss. It can be seen as gingivitis or periodontitis. Approximately 80% of adults suffer from gingivitis worldwide. Bacteria are essential for the development of this destructive disease. Although many of these bacteria are normal oral microflora, some risk factors help them produce biofilm, which causes inflammation in the oral cavity. Numerous therapeutic approaches are used to treat periodontal disease, minimize its symptoms, and possibly restore lost tissues, including behavioral-change techniques, systemic and local chemical drugs (chlorhexidine, zinc oxide, and silver-containing materials), and different kinds of surgeries. Natural materials comprise various chemical structures that have several biological activities. Therefore, they are at the center of attention in this decade. Herbal medicines have been used to manage periodontal disease, owing to their general safety and efficacy. Some of these studies are performed on volunteer patients, and some of them on laboratory animals. In this review, the results of in vitro, in vivo, and clinical trial studies (Recent decade) of chemical and herbal medicinal materials were collected to treat periodontal diseases to help future studies. © 2022 Elsevier Ltd
Yazdanian, A.R.,
Rostamzadeh, Pouya,
Rahbar, Mahdi,
Alam, Mostafa,
Abbasi, Kamyar Publication Date: 2022
Bioinorganic Chemistry and Applications (15653633)
Orodental problems have long been managed using herbal medicine. The development of nanoparticle formulations with herbal medicine has now become a breakthrough in dentistry because the synthesis of biogenic metal nanoparticles (MNPs) using plant extracts can address the drawbacks of herbal treatments. Green production of MNPs such as Ag, Au, and Fe nanoparticles enhanced by plant extracts has been proven to be beneficial in managing numerous orodental disorders, even outperforming traditional materials. Nanostructures are utilized in dental advances and diagnostics. Oral disease prevention medicines, prostheses, and tooth implantation all employ nanoparticles. Nanomaterials can also deliver oral fluid or pharmaceuticals, treating oral cancers and providing a high level of oral healthcare. These are also found in toothpaste, mouthwash, and other dental care products. However, there is a lack of understanding about the safety of nanomaterials, necessitating additional study. Many problems, including medication resistance, might be addressed using nanoparticles produced by green synthesis. This study reviews the green synthesis of MNPs applied in dentistry in recent studies (2010-2021). © 2022 Mohsen Yazdanian et al.
Yazdanian, A.R.,
Alam, Mostafa,
Rafiee, Esmail,
Tahmasebi, Elahe,
Ghaffarpasand, Arash Publication Date: 2022
Dentistry 3000 (21678677)(1)
Objectives: Root canal treatment (RCT) has high technical sensitivity, and many human procedural errors can compromise the success of treatment and well-being of patients. The failure modes and effects analysis (FMEA) is a risk assessment and management tool that ensures the safety of patient care by a systematic approach to failures. This study aimed to identify the potential errors and failures in the process of RCT using the FMEA. Methods: This descriptive study evaluated the failure modes and their effects qualitatively and quantitatively using the FMEA methodology. For this purpose, a FMEA team was first established and the steps of RCT were described in a flowchart. Next, the potential errors and failures in each step were identified, and each failure mode was scored from 1 to 10, based on the severity of impact, likelihood of occurrence, and likelihood of detection. The three scores were multiplied to obtain the risk priority number (RPN). Corrective measures and preventive strategies were suggested for high-risk failure modes (RPN≥250). Results: The FMEA identified 19 steps and 48 potential failures in the process of RCT. The maximum RPN in the process of RCT was assigned to file fracture in the root canal (RPN=324), apical extrusion of irrigating solution (RPN=320), and inappropriate or no rubber dam isolation (RPN=315). Conclusion: The FMEA has high efficacy for detection and prioritization of improvable points in a complex dental procedure in a busy department such as the endodontics department. Copyright: ©2022 Yazdanian M, et al.
Hakim, Lotfollah Kamali,
Yazdanian, A.R.,
Alam, Mostafa,
Abbasi, Kamyar,
Tebyaniyan, Hamid Publication Date: 2021
Evidence-based Complementary and Alternative Medicine (1741427X)
Biomaterials applications have rapidly expanded into different fields of sciences. One of the important fields of using biomaterials is dentistry, which can facilitate implantation, surgery, and treatment of oral diseases such as peri-implantitis, periodontitis, and other dental problems. Drug delivery systems based on biocompatible materials play a vital role in the release of drugs into aim tissues of the oral cavity with minimum side effects. Therefore, scientists have studied various delivery systems to improve the efficacy and acceptability of therapeutic approaches in dental problems and oral diseases. Also, biomaterials could be utilized as carriers in biocompatible drug delivery systems. For instance, natural polymeric substances, such as gelatin, chitosan, calcium phosphate, alginate, and xanthan gum are used to prepare different forms of delivery systems. In addition, some alloys are conducted in drug complexes for the better in transportation. Delivery systems based on biomaterials are provided with different strategies, although individual biomaterial has advantages and disadvantages which have a significant influence on transportation of complex such as solubility in physiological environments or distribution in tissues. Biomaterials have antibacterial and anti-inflammatory effects and prolonged time contact and even enhance antibiotic activities in oral infections. Moreover, these biomaterials are commonly prepared in some forms such as particulate complex, fibers, microspheres, gels, hydrogels, and injectable systems. In this review, we examined the application of biocompatible materials in drug delivery systems of oral and dental diseases or problems. © 2021 Lotfollah Kamali Hakim et al.
Yazdanian, A.R.,
Rahmani, Aghil,
Tahmasebi, Elahe,
Tebyaniyan, Hamid,
Yazdanian, Alireza Publication Date: 2021
Mini-Reviews In Medicinal Chemistry (13895575)(7)
In modern dentistry, nanomaterials have strengthened their foothold among tissue engineering strategies for treating bone and dental defects due to a variety of reasons, including trauma and tumors. Besides their finest physiochemical features, the biomimetic characteristics of nanomaterials promote cell growth and stimulate tissue regeneration. The single units of these chemical substances are small-sized particles, usually between 1 to 100 nm, in an unbound state. This unbound state allows particles to constitute aggregates with one or more external dimensions and provide a high surface area. Nanomaterials have brought advances in regenerative dentistry from the laboratory to clinical practice. They are particularly used for creating novel biomimetic nanostructures for cell regeneration, targeted treatment, diagnostics, imaging, and the production of dental materials. In regenerative den-tistry, nanostructured matrices and scaffolds help control cell differentiation better. Nanomaterials recapitulate the natural dental architecture and structure and form functional tissues better compared to the conventional autologous and allogenic tissues or alloplastic materials. The reason is that novel nanostructures provide an improved platform for supporting and regulating cell proliferation, differen-tiation, and migration. In restorative dentistry, nanomaterials are widely used in constructing nano-composite resins, bonding agents, endodontic sealants, coating materials, and bioceramics. They are also used for making daily dental hygiene products such as mouth rinses. The present article classifies nanostructures and nanocarriers in addition to reviewing their design and applications for bone and dental regeneration. © 2021 Bentham Science Publishers.
Tafazoli Moghadam, Ehsan,
Yazdanian, A.R.,
Alam, Mostafa,
Tebyaniyan, Hamid,
Tafazoli, Ali Publication Date: 2021
Journal of Materials Research and Technology (22387854)
Tissue regeneration is a vital phenomenon in the skeletal system of human beings during their life span. The structure of bony architecture and teeth are highly dependent to this ongoing procedure to maintain their functional form. Regarding the fundamental function of our skeletal system, all the involved components are at constant risk for injuries and deformations throughout the life. Therefore, in modern medicine, promotion of bone and tooth regeneration has become a critical counter measure to correct these acquired defects. There are numerous ways to address the bone and tooth related erosive pathologies but utilization of natural compounds has gained immense popularity in recent years. These materials provide a broad spectrum of therapeutic agents with a variety of biological characteristics. In this review, a comprehensive exploration has been implemented to extract and categorize the relevant scientific evidence on this issue, based on the source of natural candidates and the potential clinical indications. Database searching presented a considerable data pool with more than 300 references in this field. According to the results, all the proposed items can be categorized in two major groups including scaffolding and osteogenesis (or dentinogenesis) induction. The clinical applicability of a number of them is properly demonstrated in clinical trials but for the rest, more examinations are required to reach a conclusive decision. © 2021 The Author(s)
Yazdanian, A.R.,
Arefi, Arian Hesam,
Alam, Mostafa,
Abbasi, Kamyar,
Tebyaniyan, Hamid Publication Date: 2021
Journal of Materials Research and Technology (22387854)
Dental problems including cavities, periodontitis, apical periodontitis, and pulpitis are among the most cost-consuming burden for both patients and the health care system all over the world. The pathological consequences of these complications importantly lead to tooth loss causing functional and psychological conflictions for patients. The traditional treatment includes removing the impaired tooth or its restoration using hard restorative materials that are supposed to mimic the tissue of enamel or dentine whereas these materials cannot simulate the chemical, biological, or physical characteristics of a natural tooth. Therefore, different daily-progressing methods of tissue engineering (TE) are being propounded as new and promising approaches for managing dentistry conflicts. TE is now considered almost a practical, reproducible, and clinically safe therapy for regenerating different oral and dental tissues including either the whole dental organ or its various anatomical parts. TE necessarily constitutes three angles of stem cell (SC), scaffold, and essential growth factors (GFs). Generally, scaffolds can be made of decellularized scaffolds (usually containing the extra-cellular matrix (ECM) of target organs and tissues) or biologic scaffolds (containing natural polymer). The current study aims to review the studies conducted in the recent decade on decellularized and biological scaffolds and their potential applications in modern regenerative dentistry. © 2021 The Author(s)
Publication Date: 2021
BMC Medical Education (14726920)(1)
Background: Tooth decay and periodontitis are among the most prevalent dental diseases globally with adverse effects on an individual’s general health. Recently the prevalence of dental caries has decreased significantly, but caries epidemiology remains a major problem in dental public health. This study investigated the impact of an oral health education intervention on Theory of Planned Behavior (TPB) variables, and whether changes in these variables persisted and were associated with changes in identified oral health behaviors at 2-month follow-up. Methods: This descriptive pre/post test study was conducted with 160 staff in the Baqiyatallah Hospital in Tehran. Six hospital wards were selected using a randomized multi-stratified sampling frame. The size for each cluster was calculated as 22 with each ward being allocated to either the intervention or the control arm of the study. Self-report questionnaires were used to evaluate socio-demographic factors, dental attendance as well as the constructs of the augmented TPB model (attitudes, subjective norms, perceived behavioral control intentions). The intervention was an educational program based on TPB constructs delivered via direct training to half the participants. The control group was provided with usual training only. The independent-samples T-test, Repeated-Measures one-way ANOVA, and matched T-test with the significance level set at p < 0.05 were applied. Results: Findings revealed significant variations between the two groups immediately after the educational intervention concerning the attitudes, subjective norms, perceived behavioral control, intentions to seek treatment, oral health behavior as well as decayed, missing, and filled teeth and bleeding on probing (p<0.001). Two months after the intervention, except for the brushing construct (p = 0.18), the differences between the two groups were all statistically significant (p<0.001). Conclusion: Our findings affirm the positive effect an oral health education program has on enhancing the attitudes, subjective norms, perceived behavioral control, intentions and behavior of staff in this hospital. The results of our study confirm that developing and applying an educational intervention in accordance with the theory of planned behavior can lead to significant changes in the knowledge, attitudes, and behavior of hospital staff regarding preventing tooth decay. © 2021, The Author(s).
Publication Date: 2021
Biointerface Research in Applied Chemistry (20695837)(1)
Acute promyelocytic leukemia is the most prevalent AML malignancy. The side effects caused by chemotherapeutic drugs have primarily led to the increased use of natural products for cancer treatment. Gaillardin, a medicinal herb, has been reported to have anti-proliferative effects on various cancer cells. In this study, cytotoxic and apoptotic effects of Gaillardin were investigated on acute promyelocytic leukemia cell lines, NB4. Different concentrations of Gaillardin were used to treat NB4 cells for 48 and 72 hours. Then cell viability was assessed using MTT assay. Flow cytometry was applied to the assessment of apoptosis by using Annexin V and Propidium iodide staining method. In order to determine the expression levels of Bax and Bcl-2, RT-PCR was carried out. Statistical data analysis was done by ANOVA (one-way). MTT assay results showed that Gaillardin concentrations of 7, 8, and 9 µM would significantly reduce the percentage of live cells (P< 0.001)c. Flow cytometry results showed that Gaillardin significantly increased apoptotic cell percentage in comparison with the control groups (p< 0.05). Gaillardin can be considered as a candidate for further studies on the methods for treating various cancer types. © AMG Transcend Association. All rights reserved.
Motallaei, Mohammad Nima,
Yazdanian, A.R.,
Tebyaniyan, Hamid,
Tahmasebi, Elahe,
Alam, Mostafa Publication Date: 2021
Evidence-based Complementary and Alternative Medicine (1741427X)
Background. Dental caries is known as a multimicrobial disease. Caries are very prevalent in numerous countries, and the incidence is higher in underdeveloped countries than in developed countries. Dental caries is a major public health problem, and it is the most prevalent health problem across the world, affecting 2.4 billion people. Natural mouthwashes can be beneficial in the prevention of dental caries and oral infections without the side effects of synthetic mouthwashes. Aim. The aim of the present study was to investigate the antibacterial, antifungal, and cytotoxicity properties of sea salt from different areas of Iran. Methods and Materials. Sea salts from different areas (Urmia, Qom, and Jarquyeh) of Iran were collected. In order to define the elemental and mineralogical features of different salt samples, X-ray powder diffraction (XRD) was employed. Different concentrations (0.19-50 mg/mL) of sea salt were used in the antimicrobial and antibiofilm tests. The antimicrobial (MIC, MBC, MFC, and DAD tests) and antibiofilm (formation and degradation tests) effects were evaluated against L. acidophilus, S. aureus, E. coli, S. mitis, S. mutans, S. salivarius, and C. albicans. The cytotoxic effect of salts was evaluated on human gingival fibroblasts by the MTT test. Results. The range of MIC values in mg ml-1 was as follows: S. salivarius (50), S. mutans (50), S. mitis (50), L. acidophilus (12.5 to >50), C. albicans (50), E. coli (12.5 to 25), and S. aureus (12.5 to 25), while MBC values were, S. mutans (>50), S. salivarius (>50), S. mitis (>50), L. acidophilus (50 to >50), C. albicans (>50), E. coli (50), and S. aureus (50). MTT results showed that more than 50% of cell viability depends on decreasing the salt concentration (<1.56 mg/ml). Conclusion. Sea salts had significant antimicrobial effects on cariogenic bacteria and C. albicans. Therefore, sea salts can be a suitable candidate for mouthwash. © 2021 Mohammad Nima Motallaei et al.
Tahmasebi, Elahe,
Yazdanian, A.R.,
Rafiei, Esmail,
Yaraghi, Navid,
Karamali, Mazyar Publication Date: 2021
Journal of Military Medicine (17351537)(4)
Background and Aim: Evidence-Based Dentistry (EBD) is an approach to preserve the oral health through proper integration of scientific evidence and oral and medical conditions of the patient, clinical skills of the dentist, and the priorities of the patient. This research was conducted to study the Evaluation of Evidence-Based Dental Care (EBD) that was performed at Shahid Shokri Dental Center. Methods: This study was an applied research and a descriptive-analytical one which was done by the cross-sectional method in 2019. The statistical populations were consisted of all dentists working in Shahid Shokri Dental Center and selected by simple sampling method. Data collection was done through library study and field observation by a researcher-made questionnaire and EBD tool. Data analysis was performed using Spss software, statistical analysis methods and Pearson correlation test. Results: The mean score of dentists' knowledge about EBD was 34.27 ± 0.685; attitude score was 32.73 ± 0.641 and clinical evidence resource access score was 33.57 ± 0.638. There was a significant relationship between the level of knowledge of dentists and their field of study and history. There was a significant relationship between attitude level with age and field of study. In the area of dentists 'access to clinical evidence sources, there was a significant relationship between access level with age and field of study. Dentists' use of guides in selected sections had a medium to high spectrum, which was evaluated as good by dentists in prosthetics. Clinical guides (guidelines) for the ward, endo, orthodontic and restoration ward were updated. Conclusion: The status of EBD care at Shahid Shokri Dental Center and the details of this skill were assessed based on its average components. There was no negative attitude, but there was a need to strengthen, hospitalize and create the right conditions for EBD dentists. It is recommended to conduct comprehensive training courses, discourse building, system design, and EBD-based assessment mechanisms and update the guidelines at Shahid Shokri Dental Center. © 2021 Baqiyatallah University of Medical Sciences. All rights reserved.
Yazdanian, A.R.,
Rafiei, Esmail,
Rahmani, Aghil,
Tahmasebi, Elahe,
Hajiesfandiari, Abbas Publication Date: 2021
Dentistry 3000 (21678677)(1)
One of the most important occupational stresses that dentists encounter in their profession is patients' lawsuits. The present study aimed to evaluate common procedural errors that lead to lawsuits in dentistry. In the present cross-sectional study, all the patient files of three large dental clinics in Tehran were evaluated from 2014 to 2019, in which a dentist's negligence had been confirmed by the specialty dental committee. Files with incomplete clinical data, without the dentist's name, and the type of the lawsuit were excluded. After extraction of the data from the existing files and completing the relevant checklist, data were analyzed with SPSS 23. Most lawsuits were of the therapeutic type (82%), with 31.9%, 24.2%, and 17.6% related to prosthodontics, endodontics, and surgery, respectively. Most plaintiffs were 30-49 years of age (52%), and most were women (65%). Over half of the lawsuits had been filed against dentists with a job experience of <10 years and against general dental practitioners (76%). One of the most important ways to prevent errors leading to lawsuits is to increase dentists' knowledge about previous lawsuits. Knowledge about the most common lawsuits and the provision of organizational guidelines will help manage and decrease such lawsuits. © 2021 University Library System, University of Pittsburgh. All rights reserved.
Soudi, Armin,
Yazdanian, A.R.,
Ranjbar R.,
Tebyaniyan, Hamid,
Yazdanian, Alireza Publication Date: 2021
EXCLI Journal (16112156)
Recently, a growing attention has been observed toward potential advantages of stem cell (SC)-based therapies in regenerative treatments. Mesenchymal stem/stromal cells (MSCs) are now considered excellent candidates for tissue replacement therapies and tissue engineering. Autologous MSCs importantly contribute to the state-of-the-art clinical strategies for SC-based alveolar bone regeneration. The donor cells and immune cells play a prominent role in determining the clinical success of MSCs therapy. In line with the promising future that stem cell therapy has shown for tissue engineering applications, dental stem cells have also attracted the attention of the relevant researchers in recent years. The current literature review aims to survey the variety and extension of SC-applica-tion in tissue-regenerative dentistry. In this regard, the relevant English written literature was searched using key-words: “tissue engineering”, “stem cells”, “dental stem cells”, and “dentistry strategies”. According to the available database, SCs application has become increasingly widespread because of its accessibility, plasticity, and high proliferative ability. Among the growing recognized niches and tissues containing higher SCs, dental tissues are evidenced to be rich sources of MSCs. According to the literature, dental SCs are mostly present in the dental pulp, periodontal ligament, and dental follicle tissues. In this regard, the present review has described the recent findings on the potential of dental stem cells to be used in tissue regeneration. © 2021, Leibniz Research Centre for Working Environment and Human Factors. All rights reserved.
Motallaei, Mohammad Nima,
Yazdanian, A.R.,
Tebyaniyan, Hamid,
Tahmasebi, Elahe,
Alam, Mostafa Publication Date: 2021
Evidence-based Complementary and Alternative Medicine (1741427X)
Dental plaque is a biofilm composed of complex microbial communities. It is the main cause of major dental diseases such as caries and periodontal diseases. In a healthy state, there is a delicate balance between the dental biofilm and host tissues. Nevertheless, due to the oral cavity changes, this biofilm can become pathogenic. The pathogenic biofilm shifts the balance from demineralization-remineralization to demineralization and results in dental caries. Dentists should consider caries as a result of biological processes of dental plaque and seek treatments for the etiologic factors, not merely look for the treatment of the outcome caused by biofilm, i.e., dental caries. Caries prevention strategies can be classified into three groups based on the role and responsibility of the individuals doing them: (1) community-based strategy, (2) dental professionals-based strategy, and (3) individual-based strategy. The community-based methods include fluoridation of water, salt, and milk. The dental professionals-based methods include professional tooth cleaning and use of varnish, fluoride gel and foam, fissure sealant, and antimicrobial agents. The individual-based (self-care) methods include the use of fluoride toothpaste, fluoride supplements, fluoride mouthwashes, fluoride gels, chlorhexidine gels and mouthwashes, slow-release fluoride devices, oral hygiene, diet control, and noncariogenic sweeteners such as xylitol. This study aimed to study the research in the recent five years (2015-2020) to identify the characteristics of dental biofilm and its role in dental caries and explore the employed approaches to prevent the related infections. © 2021 Mohammad Nima Motallaei et al.
Tahmasebi, Elahe,
Alam, Mostafa,
Yazdanian, A.R.,
Tebyaniyan, Hamid,
Yazdanian, Alireza Publication Date: 2020
Journal of Materials Research and Technology (22387854)(5)
Reconstructive orthodontics is increasingly benefiting from regenerative medicine and tissue engineering strategies. The scaffolds used both in reconstruction or in the regenerationof dental/oral defects are mainly are from two sources of materials: biologic or organic.The biologic materials have been used for regeneration and functional reconstruction ofdefected or lost tissues. The 3D scaffold from organic materials, including; collagen andhyaluronic acid derivatives with macromolecular properties similar to natural ECM. Boneand dentine regeneration is a growing field of research in dentistry and envisions clinicalpromises by improving the outcomes for the treatment of craniofacial repair and replacement. This has been recently accelerated with innovative materials and bioactive moleculesand growth factors using in vitro or in vivo bioreactors. Both scaffolds made from biologic andorganic materials have been combined with adult stem cells with mesenchymal phenotypein a biomimicry approach to creating the more natural-like bone substitutes. This researchcritically reviewed the literature in the past ten years from databases (PubMed and NCBI). © 2020 The Authors.
Moghadam, Ehsan Tafazoli,
Yazdanian, A.R.,
Tahmasebi, Elahe,
Tebyaniyan, Hamid,
Ranjbar R. Publication Date: 2020
European Journal of Pharmacology (00142999)
Since the time that human population comprehended the importance of general health maintenance and the burden of disease, there has been a search for healing properties in the natural environment. Herbal medicine is the use of plants with medical properties for prevention and treatment of conditions that can affect general health. Recently, a growing interest has been observed toward the use of traditional herbal medicine alongside synthetic modern drugs. Around 80% of the population, especially in developing countries relies on it for healthcare. Oral healthcare is considered a major part of general health. According to the world health organization (WHO), oral health is considered an important part of general health and quality of life. The utilization of natural medications for the management of pathologic oro-dental conditions can be a logical alternative to pharmaceutical methods due to their availability, low costs, and lower side effects. The current literature review aimed at exploration of the variety and extent of herbal products application in oral health maintenance including different fields of oral healthcare such as dental caries, periodontal maintenance, microbial infections, oral cancers, and inflammatory conditions. © 2020 Elsevier B.V.
Yazdanian, A.R.,
Armoon, Bahram,
Noroozi, Alireza,
Mohammadi, Rasool,
Bayat, Amir-Hosein Publication Date: 2020
BMC Oral Health (14726831)(1)
Background: The aim of our study was to perform a systematic review of the literature and meta-analysis in order to investigate relationship between drug use and oral health. Methods: We searched for studies in English published before July 1, 2019 on PsycINFO, PubMed, SciELO, Scopus, and Web of Science. We assessed the relationship between drug use (methamphetamines, heroin; opiates; crack, cocaine and cannabis as dependent variables) and reported tooth loss, periodontal disease, or decayed, missing, and filled teeth index as an independent variable. The data were analyzed using Stata 12.0 software. Results: We initially identified 1836 potential articles (with 1100 duplicates) and screened the remaining 736 titles and abstracts, comprising 54 studies. In the next step, we evaluated the full-texts; 44 studies were excluded, accordingly. In total, we included 10 publications in the meta-analysis. Drug type was associated with periodontal disease (OR 1.44; 95% CI 0.8-2.6) and pooled estimates showed that type of drug used increased the odds of the number of decayed, missed and filled teeth (DMFT) (OR 4.11; 95% CI 2.07-8.15) respectively. Conclusions: The analytical challenges of segregating the impact of individual drug types on oral health diseases mean that investigations on the direct relationship between oral health status and drug use are limited. Developing programs to improve potential confounding with various substances and addressing the dental health needs of people who use drugs is vital if we are to improve their overall quality of life. © 2020 The Author(s).
Publication Date: 2020
Journal of Military Medicine (17351537)(5)
Background and Aim: According to the clinical approach of standards of oral health system, designing specific standards is necessary to guarantee health promotion activities in the dental clinic. The aim of this study was to develop the standards of the health promotion dental center and to evaluate the performance status of a military dental clinic based on the standards. Methods: An applied descriptive study of consecutive (qualitative and quantitative) method was conducted in 2019. At the qualitative stage, the standards were collected and analyzed through library study and Delphi method. To obtain expert opinions, the draft of each standard axis including, title and standard definition, target expression; definition of sub-standards and criteria was provided to 11 participants through a Delphi questionnaire. In the quantitative phase for evaluating the studied center, the data were collected using the Health Promotion Dental Standards Checklist tool derived from the qualitative phase. The checklists were completed by the assessment team at the study center and their data were analyzed using SPSS-16 software. Results: The Health Promotion Dentistry Standards consisted of 6 axes of management policy, patient evaluation, patient notices and interventions, promoting a healthy workplace, continuity and collaboration, and 61 criteria were approved by experts by the content and standards of the two Delphi rounds. The quantitative results of the standards assessment were evaluated on the medium level. Among the standards, the highest score was for management policy evaluation, 68.62% of the total score. Patient evaluation was scored 66.66% on the axis, followed by patient notices and interventions scored 52.38% and continuity in treatment and participation scored 48.80% of the total score. The lowest score was 41.66% on promoting a healthy workplace. Conclusion: Health promoting standards are necessary for dental centers with a core health mission and to establish a mechanism for evaluating their performance in implementing health promotion programs. In order to improve the quality of oral health services, it is recommended that policymakers and managers of dental centers be effective in improving health-based dental services by establishing coherent policies within the framework of health promotion standards. © 2020 Baqiyatallah University of Medical Sciences. All rights reserved.
Yazdanian, A.R.,
Ghanizadeh, Ghader,
Rastgoo, Shirin,
Shokouh, Sayyed Morteza Hosseini Publication Date: 2020
Gene Reports (24520144)
Inorganic mercury (Hg), which predominant component in dental amalgam, is one of the primary sources of Hg inhalation exposure with several systemic toxicities in dental staff. This research investigated occupational Hg exposure and its effects on kidney function biomarkers (KFBs) and superoxide dismutase (SOD) as an oxidative stress index in dental workers. The participants were classified into two matched groups as an exposed group (G1: n = 30), which occupied in endo, pediatric and restorative wards, and non-exposed (G2: n = 27) occupied in the administrative wards. Blood and urinary level of Hg(B-Hg and U-Hg), SOD blood level(SODB), and KFBs including urinary N-acetyl-β-D-glycosaminidase;U-NAG, microalbumin; U-Micro- Alb, immunoglobulin G; U-IgG, and creatinine; U-Cr were measured in 24 collected urine and blood samples and the correlations of B-Hg and U-Hg concentrations with these markers were analyzed. The mean of BHg and UHg concentrations in G1 with significant difference was higher than G2 (p < 0.05). The SODB in G1 and G2 was 59.40 ± 8.75 IU/L and 64.69 ± 8.56 IU/L, respectively, which had significant difference (p < 0.05). UIgG in G1 was higher than the G2 group with non- significance difference (p = 0.341). U-Hg and B-Hg concentrations had not significant correlation with KFBs and SODB in G1 and G2. Using dental amalgam can lead to the accumulation of Hg in blood and urine and may pose perturbation in oxidative stress index and relevant dysfunctions. So, monitoring of Hg concentration and its influences on kidney function and oxidative stress index in exposed groups is hardly suggested for health status prediction of these groups. © 2020 Elsevier Inc.
Yazdanian, A.R.,
Tabesh, Hadi,
Houshmand, Behzad,
Tebyaniyan, Hamid,
Soufdoost, Reza Sayyad Publication Date: 2020
Biocybernetics and Biomedical Engineering (02085216)(4)
Synthetic scaffolds, as an alternative to allograft and xenograft scaffolds, are suitable for bone regeneration. This study aimed to synthesize a composite biomaterial of zeolite and beta-tricalcium phosphate (βTCP) to obtain a biocompatible material with physical and mechanical properties in bone regeneration. One scaffold without zeolite (βZG 0) and two scaffolds with different amounts of zeolite (βZG 1 and βZG 2) were synthesized. The scaffolds were evaluated by FTIR, XRD, compressive strength test, MTT assay, and radiographic and histological analyses. The XRD results confirmed the presence of βTCP and ZSM-5 phases in the composite scaffolds and also, indicated that the addition of gelatin decrease the crystallinity of composite scaffolds. FTIR revealed the gelatin, β-TCP and ZSM-5 functional groups in the composite structure. βZG 2 group had the maximum porosity among the scaffolds (74%) ranging in size from 61-600 µm. Compressive strength test showed that the Young's modulus changed from 23 MPa to 59 MPa, and the zeolite nanostructure was the most influential factor responsible for this change. The MTT assay showed the superiority of βZG 2, and the macroscopic and microscopic results at 4, 8, and 12 weeks revealed the maximum bone regeneration and formation of bone trabeculae in the βZG 2 and βZG 1 groups, respectively. The zeolite scaffold showed the superior mechanical, radiographic and histological properties compared with the control and non-zeolite scaffold. βTCP/ Zeolite/ Gelatin scaffold can be an appropriate candidate for medical application in bone regeneration. © 2020 Nalecz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences
Dalaie, Kazem,
Yassaee, Vahid Reza,
Behnaz, Mohammad,
Yazdanian, A.R.,
Jafari, Farbod Publication Date: 2020
Dental and Medical Problems (1644387X)(4)
Background. The myosin 1H (MYO1H) gene, located on chromosome 12, encodes the unconventional MYO1H protein, which is involved in the intracellular movement and morphology of chondrocytes, and plays a vital role in the prognathism or retrognathism of the mandible. Objectives. The objective of this study was to assess the relationship between the polymorphisms of the MYO1H gene and mandibular prognathism in the Iranian population. Material and methods. The current project evaluated 64 patients with mandibular prognathism re-quiring orthognathic surgery and 60 controls with skeletal class I occlusion. Genome amplification was performed using specific primer pairs to assess the rs10850110 and rs11611277 polymorphisms of the MYO1H gene through the polymerase chain reaction (PCR). The restriction fragment length polymorphism (RFLP) technique was used to detect single-nucleotide polymorphisms. The data was analyzed using the χ2 test. Results. The patient and control groups were not significantly different in terms of age or gender (p > 0.05). In all, 3.1% of patients and 6.7% of controls had the rs10850110 polymorphism (p = 0.680), and 1.6% of patients and 5% of controls had the rs11611277 polymorphism (p = 0.602). Conclusions. No significant correlation was noted between the rs10850110 and rs11611277 polymorphisms of the MYO1H gene and mandibular prognathism in the Iranian population. However, the lower frequency of these polymorphisms in the patient group suggests a possible association with mandibular retrognathism, which needs to be investigated with a larger sample size. © 2020 by Wroclaw Medical University.
Soufdoost, Reza Sayyad,
Mosaddad, Seyed Ali,
Salari, Yalda,
Yazdanian, A.R.,
Tebyaniyan, Hamid Publication Date: 2020
Biointerface Research in Applied Chemistry (20695837)(5)
In this study, a novel Polycaprolactone suture assembled with Tadalafil was investigated to improve wound healing processes via vascular stimulation. Tadalafil/Polycaprolactone (TP) suture was developed by the electrospinning method. The designed suture was characterized by SEM, mechanical properties assessments, tensile strength measurements and the drug release study. For in vivo tests, rats were classified into two study groups. An incision was made on their back skin and they were sutured with TP suture and Polycaprolactone suture as control. Rats were sacrificed at 7 days following surgery for histopathological examinations with Hematoxylin and Eosin staining. Results of Tensile test demonstrated that the lowest tensile strength belonged to 3 and 4 % wt and the highest tensile strength belonged to 1 and 2 % wt of TP suture. The rate of Tadalafil release showed that the highest drug release was related to 3 and 4% wt which were about 125 to 210 μg during 15 days. The histopathology revealed that the number of blood vessels, collagen fibers, fibroblast, polymorphonuclear leukocytes, and epithelization was remarkable in Tadalafil/Polycaprolactone group during 7-day. A novel Tadalafil/Polycaprolactone suture improved the processes of wound healing by releasing the Tadalafil drug around the sutured wound and can be used in medical applications. © 2020 by the authors.
Tahmasebi, Elahe,
Alikhani, Milad,
Yazdanian, Alireza,
Yazdanian, A.R.,
Tebyaniyan, Hamid Publication Date: 2020
Life Sciences (00243205)
Head and neck cancer (HNC) constitute 5% of all reported cancers. Among all, the oral cavity cancer is the most frequent type of HNC which accounts for over half of HNC cases. Mouth cancer ranks the sixth leading cause of cancer-related mortality. Generally, conventional chemotherapy has shown success at decreasing relapse and metastasis rates and improves the overall prognosis. Recently, target therapy and targeted drug delivery systems have been introduced as promising treatments. The elimination of efficiency of current therapeutic strategies due to the spared cancer stem cells that cause chemotherapy resistance, relapse and metastasis. Inefficiency methodologies in the elimination of all cancer cells in the body are a major problem that remained to be resolved before to confront the new cancer therapies. Many studies imply to cancer stem cell markers as important agents for targeted anti-cancer as well as improving chemotherapy efficiencies. The potentials of targeted cancer therapy led us to search for novel markers in the mouth cancer stem cells especially in rare cancers. The aimed of this research was, first a comprehensive critical review of the previous studies on the markers of cancer stem cells in oral cancers including oral squamous cell carcinoma, salivary gland cancers, and to highlight the most common cancer stem cell markers which have potential to be exploited as indicators for the preneoplastic lesion malignancy, oral cancer progression, and/or treatment prognosis. © 2020 Elsevier Inc.
Soufdoost, Reza Sayyad,
Yazdanian, A.R.,
Tahmasebi, Elahe,
Yazdanian, Alireza,
Tebyaniyan, Hamid Publication Date: 2019
Biocybernetics and Biomedical Engineering (02085216)(3)
Different composite materials have been investigated in bone regeneration but none of them have a significant regeneration in a short time. In this study, the novel scaffold with the osteoinductive characteristic in order to accelerate bone regeneration for 6 weeks. Tadalafil/β-TCP/Collagen (TβC) and β-TCP/Collagen (βC) composite scaffolds were prepared and analyzed by porosity, biodegradability and MTT tests. And then, three bone defects (8 mm diameter, n = 6 group) were produced and filled with TβC, βC scaffolds and the third defect was unfilled as a control. Samples were taken and evaluated by histological, radiological and histomorphometric evaluation at 4 and 6 weeks. In vitro tests showed that both scaffold approximately had the same results in the percentage of porosity and in vitro cytotoxicity. Biodegradability of the βC scaffold was more than TβC scaffold. In vivo test showed bone regeneration was more in TβC scaffold at 6 weeks based on radiological and histopathologic analysis compared with βC scaffold and control groups. Histomorphometric analysis showed that the amount of the bone regeneration was significant in TβC group in comparison βC and control groups (P < 0.05) at 6 weeks. This study highlights the promising application of TβC scaffold with Tadalafil for successful bone regeneration by enhancing osteogenesis. © 2019
Rafie, Esmail,
Karamali, Mazyar,
Bahadori, Mohammadkarim,
Yazdanian, A.R.,
Ravangard, Ramin Publication Date: 2019
Journal of Education and Health Promotion (22779531)(1)
BACKGROUND: Today, the scope of dental activities is a broad range from the needs assessment for epidemiological studies to the implementation of comprehensive programs for the prevention of oral diseases at various levels of the society. This study aimed to identify and prioritize the need researches in the field of oral and dental health in a dental hospital in Tehran, Iran. METHODS: This applied research was a mixed methods study carried out in Tehran, Iran, in 2018. The data gathering tool included a data collection form used for reviewing the documents, a semi‑structured interview, and an open questionnaire. MAXQDA 10.0, Expert Choice 11.0, and Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) software were used for analyzing the collected data. RESULTS: After analyzing the results of the qualitative phase, 171 research topics in 6 areas were obtained, including 44 topics in “dental clinical care and treatment,” 37 topics in “health and prevention,” 19 topics in “education and health promotion,” 37 topics in “management of dental care delivery,” 16 topics in “policy and its requirements,” and 18 topics in “dentistry materials, equipment and technologies.” CONCLUSION: According to the results, it can be recommended that the research resources should be allocated based on the priorities identified by the present study so that the studied hospital has the highest dynamic performance in achieving its goals and objectives. © 2019 Journal of Education and Health Promotion | Published by Wolters Kluwer - Medknow.
Kafshgari, Hossein Seifi,
Yazdanian, A.R.,
Ranjbar R.,
Tahmasebi, Elahe,
Mirsaeed, Seyed Rahim Ghazi Publication Date: 2019
Journal of Biological Research (Italy) (18268838)(1)
Tooth decay is one of the most common chronic diseases in humans. The aim of this study was to investigate the inhibitory effects of Citrullus colocynthis extracts on the growth of Streptococcus mutans and Candida albicans and their cytotoxic effects on normal gingival fibroblast cells and breast cancer cells. The aqueous and alcoholic extracts of C. colocynthis fruit were evaluated by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay, minimum inhibitory concentration (MICs) and minimal bactericidal concentration (MBCs)/minimal fungicidal concentration (MFCs) tests. The MICs and MBCs/MFCs were obtained from the aqueous extract (MIC 0.37 mg/mL and MBCs 1.5 mg/mL against S. mutans and MIC 0.37 mg/mL and MFCs 3.0 mg/mL against C. albicans) and ethanolic extract (MIC 0.75 mg/mL and MBCs 1.5 mg/mL against S. mutans and MIC 3.0 mg/mL and MFCs 12.0 mg/mL against C. albicans). The growth of S. mutans and C. albicans were effectively inhibited by extracts of C. colocynthis. The LC50 values of C. colocynthis on HGF1-PI cells were 4589.19 μg/mL and 3933.84 μg/mL by aqueous and ethanolic extracts, respectively. The LC50 values of C. colocynthis on MCF-7 cells were 4589.19 μg/mL and 3933.84 μg/mL by aqueous and ethanolic extracts, respectively. The extracts of C. colocynthis significantly decreased the growth of breast cancer and normal gingival fibroblast cells. The results of the study showed that the extracts may be used to treat oral mucosal diseases and prevent dental caries but future research is needed. © H.S. Kafshgari et al., 2019.
Sanaei Nasab, Hormoz,
Yazdanian, A.R.,
Mokhayeri, Yaser,
Latifi, Marzieh,
Niksadat, Negin Publication Date: 2019
International Journal of Dental Hygiene (16015029)(2)
Objective: In the present study, we attempted to assess how psychological theories (health belief model [HBM], theory of planned behaviour [TPB], social cognitive theory [SCT], clinical theories [CT] and other theories [OT]) influence oral health interventions. Methods: PubMed, Scopus, Cochrane and Web of Knowledge databases from 2000 to 2017 were searched. We defined psychological theories based on five subgroups: (A) HBM, (B) TPB, (C) SCT, (E) CT and (F) OT. Results: From the 156 identified studies, 19 studies based on PICO were included. Our findings indicated that the standardized mean difference (SMD) of HBM was 0.37 (95% CI: 0.24, 0.51), which was statistically significant in improving oral health. The SMD of SCT was not significant (0.05 [95% CI: −0.33, 0.44]) in improving oral health. The SMD of TPB was significant (1.66 [95% CI: 1.06, 2.27]) in improving oral health. The SMD of CT (−4.6 [95% CI: −6.49, −2.71]) and OT (2.93 [95% CI: 1.55, 4.32]) revealed significant differences in improving oral health. Conclusion: The current meta-analysis showed that in general, psychological interventions that used OT, CT, HBM and TPB were effective in enhancing oral health status, and interventions that used SCT did not have an effect on improving oral health status. Oral health care providers who work with patients to take methods and improve behaviours that are related to appropriate oral health need to comprehend their applicability and strengths. © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Yazdanian, A.R.,
Moradi, Kiumars,
Sobhani, Vahid,
Akbari, Hamed,
Kazemipour, Maryam Publication Date: 2018
Journal of Military Medicine (17351537)(2)
Background and Aim: Musculoskeletal disorders related to work are one of the main causes of disability in the dentistry profession. Long term adoption of a repeated position, repetitive movements and inappropriate posture are risk factors for musculoskeletal disorders and need to be addressed. The present study aimed to evaluate the prevalence of work-related musculoskeletal disorders and inappropriate posture at the dentistry clinic of a military college Methods: In this study, 66 dentists of the dental clinic affiliated with a military college were evaluated by REBA (a method for quick assessment of the body) and the Nordic musculoskeletal disorders questionnaire to assess the body while working. SPSS software version 18 were used to analyze the data. Results: This population study included 29 men and 37 women with a mean age of 40.83 years who had worked for an average of 14.56 years in the dentistry clinic. REBA score in 56.1% of dentists was in the high-risk range, 39.4% was in the medium-risk range and 4.5% were in the high-risk range. Over the past 12 months, the most prevalence of musculoskeletal pain and discomfort in different areas was observed in the neck (66%). There was a statistically significant relationship between the loss of ability to perform daily activities during the past 12 months and gender and reduced working time due to musculoskeletal discomfort (P≤0.05). Conclusion: The results showed that the prevalence of musculoskeletal disorders in the dentistry clinic is high, particularly in the neck. In order to reduce problems, corrective actions should be taken as soon as possible. © 2018 University of Toronto Press Inc. All Rights Reserved.
Khojaste, Moein,
Yazdanian, A.R.,
Tahmasebi, Elahe,
Shokri, Mehdi,
Houshmand, Behzad Publication Date: 2018
European Journal of Translational Myology (20377452)(4)
Periodontitis and tooth decay are common dental diseases. There are some bacterial risk factors such as Streptococcus mutans, Aggregatibacter actinomycetemcomitans and Candida albicans complications, tubers of Cyperus rotundus was used to determine the antimicrobial effect of fungi. Considering the increasing resistance of bacteria and fungi to antibiotics and their alcoholic and aqueous extracts and essential oil on Streptococcus mutans, Aggregatibacter actinomycetemcomitans and Candida albicans, as well as an examination cytotoxicity on gingival fibroblast cells. Alcoholic and aqueous extracts and essential oil prepared from tubers of Cyperus rotundus. After bacterial and fungal cultures, the inhibition zone, Minimum inhibitory concentrations (MIC), and Minimum Bactericidal Concentration (MBC), were studied. Cytotoxicity was also evaluated using the Methyl tetrazolium test (MTT).The results showed that Cyperus rotundus alcoholic extract had the greatest effect on inhibition of growth and death of Streptococcus mutans, Aggregatibacter actinomycetemcomitans. According to the present study, Cyperus rotundus extract can be considered as a suitable candidate for the treatment and prevention of periodontitis and tooth decay. © 2018, The European Journal of Translational Myology.
Hosseini, Behnam,
Mirhadi, Seyed Mehdi,
Mehrazin, Mehdi,
Yazdanian, A.R.,
Motamedi, Mahmood Reza Kalantar Publication Date: 2017
Trauma Monthly (22517464)(5)
Background: Recently, the use of synthetic bone graft substitutes has garnered attention and become more popular than traditional methods for reconstructing osseous defects in the fields of orthopedics and maxillofacial surgery. Commercially available hydroxyapatites (HAs) have been widely reported to be effective bone graft substitutes. Unfortunately, they are expensive to produce. Thus, there is a need to develop methods of producing HA bone graft substitutes from inexpensive sources. Objectives: To synthesize nanocrystalline HA using recycled eggshell and trimethyl phosphate. Until date, several phosphate solutions have been utilized for this purpose. However, this is for the first time to the best of our knowledge that trimethyl phosphate is used as a source of phosphate to synthesize eggshell-derived HA. Methods: To produce HA, calcined hen's eggshell was used as a source of calcium, and trimethyl phosphate was used as a source of phosphate in a sol-gel method at a controlled temperature. The results were estimated using scanning electron microscopy (SEM) observantion to evaluate surface morphology, X-ray diffraction (XRD) to analyze phase composition, and transmission electron microscopy (TEM) toevaluate the shape and sizeof prepared HA. Micro-chemical analysis was conducted using energy-dispersive X-ray spectroscopy (EDX). Fourier transform infrared spectroscopy (FTIR) was employedto identify the functional groups of the prepared HA. Results: XRD evaluation showed that high-purity synthetic HA powder was obtained. The results of the SEM, XRD, TEM, EDX, and FTIR analyses demonstrated that the synthesis yielded nanostructured HA. Conclusions: A complete synthesis of nanocrystalline HA was obtained by using trimethyl phosphate and eggshells in a sol-gel method at a controlled temperature. A spherical particle morphology and particle size ranged 19-41 nm were achieved. Eggshell waste material is inexpensive and can be considered a viable choice for high-volume HA powder production, based on the present results. Copyright © 2016, Trauma Monthly.
